Differential expression of programmed death‐1 according to the histological differentiation of cutaneous squamous cell carcinoma

Oh, Seong-Taek; Yang, Keum Jin; Lee, J.‐U.; Bae, Jong Myon; Park, Hue Jung; Kim, J.W.; Park, Y.M.

doi:10.1111/bjd.17850

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…No significant relationships between PD-L1/PD-1 status and tumor differentiation degree in cSCCs were found by Oh et al, which is similar to our study [ 46 ]. However, they accepted cytoplasmic staining as positive in the well-differentiated cSCC group, while our study only accepted membranous staining as PD-L1 positivity.…”

Section: Discussionsupporting

confidence: 92%

Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma

Yülek

Batur

Ozcan

et al. 2022

Bosn J of Basic Med Sci

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This study aimed to investigate the programmed cell death-ligand 1 (PD-L1) expression in cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) and its relationship with prognostic factors in tumors that are not in the head and neck region and are therefore relatively less exposed to the sun. This retrospective cross-sectional study included 25 invasive cSCC and 42 BCC cases with a diameter ≥ 2 cm located outside the head and neck region from 2010 to 2018. The biopsy samples were examined based on the membranous PD-L1 (22C3 clone) staining. Staining results were scored as follows: 0, no staining (negative); 1, < 10% PD-L1 positivity of tumor cells; and 2, ≥ 10% PD-L1 positivity of tumor cells. PD-L1 positivity was not seen in any BCC cases, whereas 11 (44%) of cSCC cases were PD-L1 positive. No significant relationship was observed between PD-L1 expression and prognostic parameters, including tumor diameter, tumor depth, and lymphovascular or perineural invasion in the cSCC group. PD-L1 expression was not associated with prognostic factors in the early stages of BCC and SCC located outside the head and neck region. Therefore, investigating the PD-L1 expression seems to be more relevant in patients with advanced-stage disease.

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Section: Discussionsupporting

confidence: 92%

Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma

Yülek

Batur

Ozcan

et al. 2022

Bosn J of Basic Med Sci

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“…A very recent study written by Oh et al 28 investigated PDL1 expression in 29 cSCC with different grading (well, moderately and poorly differentiated). Accordingly to our results, PDL1 immunoreactivity was detected in a small number of cSCCs and the authors found no significant difference in the proportion of PDL1 immunoreactivity according to the degree of cSCC differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…A very recent study written by Oh et al . investigated PDL1 expression in 29 cSCC with different grading (well, moderately and poorly differentiated).…”

Section: Discussionmentioning

confidence: 99%

Morphological and morphometric analysis of cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa: a retrospective study

Filoni

Cicco

Lospalluti

et al. 2020

Acad Dermatol Venereol

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Background Recessive dystrophic epidermolysis bullosa is a highly disabling genodermatosis characterized by skin and mucosal fragility and blistering. Cutaneous squamous cell carcinoma (cSCC) is one of the most devastating complications, having a high morbidity and mortality rate. Patients with recessive dystrophic epidermolysis bullosa were reported to have up to a 70-fold higher risk of developing cSCC than unaffected individuals. Immune cells play a role in cancer evolution. Objective The aim of our study was to evaluate immunohistological differences between cSCC in patients with and without recessive dystrophic epidermolysis bullosa. Methods A retrospective study of 25 consecutive cases was performed; five were biopsies of cSCC taken from five patients with recessive dystrophic epidermolysis bullosa; as controls we analysed 10 cSCC in subjects without recessive dystrophic epidermolysis bullosa (5 primitive, 3 postburns and 2 postradiotherapy), 5 cSCC in renal transplant recipients and 5 cutaneous pseudoepitheliomatous hyperplasia in patients with recessive dystrophic epidermolysis bullosa. Results A significant reduction of CD3+, CD4+ and CD68+ between the cSCC in patients with recessive dystrophic epidermolysis bullosa compared to primary cSCC and a significant reduction of CD3+, CD4+, CD8+ and CD20+ were observed in cSCC in patients with recessive dystrophic epidermolysis bullosa compared to secondary cSCC. On the contrary, there was no difference in CD3+, CD8+, CD20+ and CD68+ expression when comparing cSCC in patients with recessive dystrophic epidermolysis bullosa to cSCC in renal transplant recipients. No significant difference was found in size, histopathology, grading, number of mitoses and EGFR expression between the different groups. Conclusions Our data show a reduction in immune cell peritumoral infiltration. Considering the well-known evolution of cSCC in patients with recessive dystrophic epidermolysis bullosa, as well as the younger age at diagnosis, it can be assumed that immune dysfunction might contribute to the cSCC aggressiveness in these patients.

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Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs

Vasilev,

Popovska,

Petrova Kraevska

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Squamous cell carcinoma of the skin (SCCs) is the second most common skin cancer with continuously increasing incidence. Programmed cell death ligand 1 (PD-L1), Programmed cell death 1 receptor (PD-1) and CD8 expression in primary SCCs has not been described in many studies. Objective: We investigated the association between PD-L1, PD-1, CD8 and clinocopathological prognostic factors for recurrence, metastasis and mortality of SCCs. Patients and Methods: Immunohistochemically stained sections of 100 primary SCCs divided in two groups according to diameter of the tumors (<20 mm and >20mm) were assessed. Recombinant rabbit Anti-PD-L1 antibody [SP142] - C-terminal, rabbit monocloncal Anti-PD1 antibody [NAT105] and FLEX Mono Mo a Hu CD8, cl C8/144B, RTU were used. Results: We did not establish statistically significant differences between PD-L1, PD-1, CD8 expression and high-risk clinocopathological features – tumor size >20mm, depth >6mm, poor tumor cell differentiation, perineural/lymphovascular invasion, low/absent lymphocyte stromal reaction. Conclusions: In primary SCCs, the expression of PD-L1, PD-1 and CD8 is not associated with high-risk clinicopathological factors. We suggest that these immunohistochemical markers are more significant in advanced cases and metastatic tissues.

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Differential expression of programmed death‐1 according to the histological differentiation of cutaneous squamous cell carcinoma

Cited by 3 publications

References 8 publications

Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma

Relationship between PD-L1 expression and prognostic factors in high-risk cutaneous squamous and basal cell carcinoma

Morphological and morphometric analysis of cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa: a retrospective study

Relationship Between PD-L1, PD-1, CD8 and Clinicopathological Factors in Primary SCCs

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