Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy

He, Ting; Qin, Xialing; Jiang, Chao; Jiang, Dawei; Shan, Lei; Lin, Jing; Zhu, Weiguo; Qu, Junle; Huang, Peng

doi:10.7150/thno.42981

Cited by 134 publications

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“…Several key proteins corresponding to cellular pathways are likely to be sulfhydrated and form protein persulfides by H 2 S, so-called S-sulfhydration 26 , 27 . It has been revealed that H 2 S may influence the survival and death of tumor cells in a double-edged manner 19 , 28 , 29 . The presence of H 2 S, above a certain concentration, induces selective inhibition of tumor cells due to the distinctive metabolism and signaling pathways of tumor cells 22 , 27 .…”

Section: Introductionmentioning

confidence: 99%

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

et al. 2020

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Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current tumor treatment. The development of versatile drug delivery systems which present responsive characteristics to tumor microenvironment (TME) has been extensively carried out, but remains challenging. In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have been designed and prepared for co-delivery of ICG/TPZ molecules, denoted as ZSZIT, for H 2 S-amplified synergistic therapy. Methods: The ZSZ nanoparticles were characterized using SEM, TEM and XRD. The in vitro viabilities of cancer cells cultured with ZSZIT under normoxia/hypoxia conditions were evaluated by cell counting kit-8 (CCK-8) assay. In addition, in vivo anti-tumor effect was also performed using male Balb/c nude mice as animal model. Results: ZSZIT shows cascade PDT and hypoxia-activated chemotherapeutic effect under an 808nm NIR irradiation. Meanwhile, ZSZIT degrades under tumor acidic environment, and H 2 S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug. Both in vitro and in vivo studies demonstrate the H 2 S-sensitized synergistic antitumor effect based on cascade PDT/chemotherapy. Conclusion: This cascade H 2 S-sensitized synergistic nanoplatform has enabled more effective and lasting anticancer treatment.

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Section: Introductionmentioning

confidence: 99%

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

et al. 2020

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Section: Ph-responsive Tpnbs In Cdtmentioning

confidence: 99%

“…therapy (Figure 9) (He et al, 2020). BSA was used to regulate the size of MnS NPs by tuning the ratio of the proportion of BSA to that of Mn 2+ .…”

Section: Ph-responsive Tpnbs In Cdtmentioning

confidence: 99%

“…Therapeutic cargo-incorporated PNBS (TPNBS), which are capable of simultaneous pH-responsive imaging and therapy, have also attracted significant research attention (Wang et al, 2013;Li et al, 2017;Feng Q.H. et al, 2018;Zhu et al, 2018;He et al, 2020). In this review, we evaluate how the development of pH-responsive multifunctional nanomaterials has contributed toward improvements in cancer treatment using the capabilities of these sensors to increase tumor accumulation, tumor penetration, cellular uptake, and theranostic functions.…”

Section: Introductionmentioning

confidence: 99%

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Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Kumar

Park

2020

Front. Bioeng. Biotechnol.

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Polymeric nanobiosensors (PNBS) that respond to tumor-related factors, including pH, have shown great potential for disease detection owing to their selectivity and sensitivity. PNBS can be converted into theranostic polymeric nanobiosensors (TPNBS) by incorporating therapeutic cargo, thereby enabling concomitant diagnoses and therapy of targeted diseases. The polymeric compartments in TPNBS play a significant role in the development and therapeutic efficacy of nanobiosensors. Polymers enhance the stability, biocompatibility, and selective or effective accumulation of nanobiosensors at desired pathological sites. The intrinsic pH sensitivity of either the polymers in TPNBS or the TPNBS themselves provides integrated potentialities such as cogent accumulation of TPNBS at the tumor, augmented tumor penetration, cellular uptake, and theranostic activation, including enhanced bioimaging signals and controlled release of therapeutics. In this review, we summarize recent developments in the design, preparation, and characterization of pH-responsive TPNBS and their ability to behave as efficient in vivo nanotheranostic agents in acidic cancer environments.

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“…Chemodynamic therapy (CDT), an emerging therapeutic strategy, was defined as in situ treatment using the Fenton reaction or Fenton-like reaction to transform intracellular hydrogen peroxide (H 2 O 2 ) to reactive oxygen species (ROS, e.g., superoxide radical O 2 •- and hydroxyl radical HO·) in tumor sites for triggering cell apoptosis 9 - 15 . Considering that the Fenton reaction is substantially suppressed under slight alkaline conditions or in the presence of insufficient H 2 O 2 in normal tissues, CDT is considered as a novel potential modality for cancer-specific treatment 16 .…”

Section: Introductionmentioning

confidence: 99%

In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor

Chen

Zhang

et al. 2020

Theranostics

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Rationale: Vascular abnormality stemming from the hypoxia-driven elevation of proangiogenic factors is a hallmark for many solid malignant tumors, including colorectal cancer (CRC) and its liver metastasis. We report a hypoxia-triggered liposome-supported metal-polyphenol-gene bio-nanoreactor to tune the proangiogenic factor-mediated immunotolerance and synergize the elicited tumoricidal immunity for CRC treatment. Methods: With the aid of polyphenol gallic acid, Cu 2+ ion-based intracellular bio-nanoreactor was synthesized for the delivery of small interfering RNA targeting vascular endothelial growth factor and then cloaked with a hybrid liposomal membrane that harbored a hypoxia-responsive azobenzene derivative. In hypoxic tumor, the liposomal shell disintegrated, and a shrunk-size bio-nanoreactor was burst released. Intracellularly, Cu 2+ from the bio-nanoreactor catalyzed a Fenton-like reaction with glutathione, which efficiently converted H 2 O 2 to •OH and enabled a chemodynamic therapy (CDT) in tumor sites. With the alleviation of proangiogenic factor-mediated immunotolerance and high production of CDT-induced tumor-associated antigens, robust tumoricidal immunity was co-stimulated. Results: With colorectal tumor and its liver metastasis models, we determined the underlying mechanism of proangiogenic factor-mediated immunotolerance and highlighted that the liposomal bio-nanoreactor could create positive feedback among the critical players in the vascular endothelium and synergize the elicited tumoricidal immunity. Conclusion: Our work provides an alternative strategy for exerting efficient tumoricidal immunity in the proangiogenic factor-upregulated subpopulation of CRC patients and may have a wide-ranging impact on cancer immune-anti-angiogenic complementary therapy in clinics.

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Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy

Cited by 134 publications

References 0 publications

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor

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Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy

Cited by 134 publications

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ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor

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ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy