Tumor Necrosis Factor α Is Associated With Viral Control and Early Disease Progression in Patients With HIV Type 1 Infection

Vaidya, Sagar A.; Körner, Christian; Sirignano, Michael; Amero, Molly A.; Bazner, Sue; Rychert, Jenna; Allen, Todd M.; Rosenberg, Eric S.; Bosch, Ronald J.; Altfeld, Marcus

doi:10.1093/infdis/jiu206

Cited by 46 publications

(30 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there is no consensus on "biomarkers" of systemic immune activation, elevation of sCD14 has been shown to be a relatively sensitive marker for predicting HIV progression (Williams, Livak, Bahk, Keating, & Adeyemi, 2016). Other markers, such as TNF-α, have more controversial roles (de Medeiros et al, 2016;Vaidya et al, 2014). The association for sCD14 among PHIV but not PHEU underscore the potential risk of HIV progression.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth

Moscicki

Yao

Farhat

et al. 2019

J Clinic Periodontology

View full text Add to dashboard Cite

Aim To examine oral biomarkers that have been associated with periodontal disease progression in HIV‐infected adults in perinatally HIV‐infected and HIV‐exposed but uninfected youth. Material and Methods This was a cross‐sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. Results For perinatal HIV youth (n = 129), the markers consistently elevated (p < .05) in sites with GI ≥2 and in sites with BOP were interleukin‐1β, 6 and 13, macrophage inflammatory protein‐1α and metalloproteinase‐9. Serum tumour necrosis factor‐α and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV‐uninfected subjects (n = 71). Conclusions The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV‐infected youth may be at higher risk for developing significant periodontal disease, associated with tooth loss and HIV progression. More frequent dental care of this group is needed to prevent potential periodontal progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth

Moscicki

Yao

Farhat

et al. 2019

J Clinic Periodontology

View full text Add to dashboard Cite

show abstract

“…High TNF levels have been associated with poor virus control and disease progression (85,86). TNF signaling induces NF-B translocation to the nucleus, where it may bind to regulatory sequences in the HIV-1 long terminal repeat (LTR) promoter to stimulate viral transcription (87).…”

mentioning

confidence: 99%

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

Roesch

Richard

Rua

et al. 2015

J Virol

View full text Add to dashboard Cite

The HIV-1 accessory protein Vpr displays different activities potentially impacting viral replication, including the arrest of the cell cycle in the G 2 phase and the stimulation of apoptosis and DNA damage response pathways. Vpr also modulates cytokine production by infected cells, but this property remains partly characterized. Here, we investigated the effect of Vpr on the production of the proinflammatory cytokine tumor necrosis factor (TNF). We report that Vpr significantly increases TNF secretion by infected lymphocytes. De novo production of Vpr is required for this effect. Vpr mutants known to be defective for G

show abstract

“…TNF-α is a pro-inflammatory cytokine that is associated with immune activation 27 . Increased levels of TNF-α prior to cART initiation have been associated with HIV progression 28 . Furthermore, people who progressed to AIDS one year after starting cART experienced a smaller decrease in the soluble TNF-α receptor compared to those who did not 29 , suggesting that cART-induced decreases in TNF-α are protective against HIV progression.…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation

Mathad

Gupte

Balagopal

et al. 2016

JAIDS Journal of Acquired Immune Deficiency Syndromes

View full text Add to dashboard Cite

Background Women progress to death at the same rate as men despite lower plasma HIV RNA (VL). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods Inflammatory and immune activation markers (IFN-γ, TNF-α, IL-6, IL-18, IP-10, CRP, LPS, sCD14) were measured at weeks 0, 24, and 48 post-cART in a random subcohort (n=215) who achieved virologic suppression in ACTG A5175 (PEARLS). Association between sex and changes in markers post-cART was examined using random effects models. Average marker differences and 95%CI were estimated using multivariable models. Results At baseline, women had lower median log10VL (4.93 vs 5.18 copies/mL, p=0.01), CRP (2.32 vs 4.62 mg/L, p=0.01), detectable LPS (39% vs 55%, p=0.04), and sCD14 (1.9 vs 2.3 mcg/mL, p=0.06) versus men. By week 48, women had higher IFN-γ (22.4 vs 14.9 pg/mL, p=0.05), TNF-α (11.5 vs 9.5 pg/mL, p=0.02), and CD4 (373 vs 323 cells/mm3, p=0.02). In multivariate analysis, women had greater increases in CD4 and TNF-α but less of a decrease in CRP and sCD14 compared to men. Conclusions With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality.

show abstract

Tumor Necrosis Factor α Is Associated With Viral Control and Early Disease Progression in Patients With HIV Type 1 Infection

Cited by 46 publications

References 13 publications

Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth

Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

Sex-Related Differences in Inflammatory and Immune Activation Markers Before and After Combined Antiretroviral Therapy Initiation

Contact Info

Product

Resources

About