Tumor Necrosis Factor-α Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells

Gee, Katrina; Kozlowski, Maya; Kumar, Ashok

doi:10.1074/jbc.m302309200

Cited by 78 publications

(78 citation statements)

References 66 publications

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“…In those cells, lipopolysaccharide-induced sialydase activity is dependent on p42/p44 MAPK-mediated tumor necrosis factor ␣ (TNF␣) production. Subsequently, the TNF␣ that is produced mediates p38 MAPK activation, which then induces sialydase activity (40). TNF␣ plays a key role in GPA, and its increased level is associated with disease activity (41).…”

Section: Discussionmentioning

confidence: 99%

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Espy

Morelle²,

Kavian

et al. 2011

Arthritis & Rheumatism

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Objective. To investigate whether the glycosylation and sialylation levels of anti-proteinase 3 (anti-PR3) antibodies could affect their pathogenicity, and whether these levels could be correlated with the activity of granulomatosis with polyangiitis (Wegener's) (GPA).Methods. Forty-two serum samples positive for anti-PR3 antibodies from 42 patients with active or weakly active/inactive GPA were included. Anti-PR3 antibodies were assayed by enzyme-linked immunosorbent assay, and their levels of glycosylation and sialylation were assessed by enzyme-linked lectin assay. The glycosylation and sialylation levels of IgG purified from the serum of healthy donors and patients with active, remitted, or weakly active disease were assessed by permethylation and mass spectrometry analysis of glycans, following neuraminidase digestion. The neutrophil oxidative burst induced by purified IgG was assayed by spectrofluorimetry.Results. The mean sialylation ratio of anti-PR3 antibodies was significantly lower in patients with active disease than in patients with weakly active or inactive disease, and this was inversely correlated with the Birmingham Vasculitis Activity Score (BVAS) (P < 0.0001). Similar results were obtained using the BVAS/ GPA. The area under the receiver operating characteristic curve for the sialylation ratio of anti-PR3 antibodies, as a test to determine the activity of GPA, was 0.82 (P ‫؍‬ 0.0006). The characterization of N-glycans showed a decrease in 2,6-linked sialylated N-glycans and an increase in dHex 1 Hex 3 HexNAc 4 (mass/charge 1,836) agalactosylated structures in purified IgG from patients with active disease compared with controls. The anti-PR3 antibody-induced oxidative burst of neutrophils was inversely correlated with the sialylation levels of anti-PR3 IgG.

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Section: Discussionmentioning

confidence: 99%

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Espy

Morelle²,

Kavian

et al. 2011

Arthritis & Rheumatism

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“…Lipopolysaccharide (LPS) and some cytokines (as tumor necrosis factor, TNF) can induce formation of a hyaluronan-adhesive form of CD44 [57]. Such cell surface receptor CD44 is needed for polymorphonuclear leukocytes to interact and migrate on hyaluronan [58].…”

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confidence: 99%

The ubiquitous hyaluronan: Functionally implicated in the oviduct?

et al. 2016

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Hyaluronan (hyaluronic acid) is a simple, non-antigenic, non-sulphated glycosaminoglycan (GAG) present everywhere in the extracellular compartments of the body. Noteworthy, it is highly conserved phylogenetically, from sauropsida to mammals; and plays a plethora of roles from embryonic/fetal development to adult physiological and pathological events, including tumor development. In reproduction, hyaluronan has proven related to initial events as sperm survival, build-up of the sperm reservoir in the oviduct, regulation of sperm capacitation and pre-fertilization to later participate in embryo, fetal and placental development. Synthesis, binding (via the CD44 membrane receptor) and degradation of hyaluronan occur in male and female genital organs, the oviduct being no exception. This review discusses our current knowledge on roles of this ubiquitous GAG on the survival of immunologically foreign spermatozoa in the pig oviduct, a relevant event for fertility. During pre-ovulatory storage in the functional tubal sperm reservoir, spermatozoa are entrapped in a mucus-like tubal fluid.This fluid contains fluctuating levels of hyaluronan, which is synthesized by the lining 18th ICAR-2016-S2. Pig reproduction Symp 2 epithelium by HA-synthase 3 (has3). Both hyaluronan and its CD44-receptor are particularly evident in the deep mucosal furrows of the sperm reservoir, where most spermatozoa are embedded in; kept alive, un-capacitated but also undetected by the immune system of the female. Hyaluronan is also present in the seminal plasma, and evidence points out an involvement of hyaluronan and its receptor in the local (tubal and possibly uterine) production of anti-inflammatory cytokines, such as IL-10, pertaining maternal immune tolerance of these foreign cells.

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“…Chronic aggressive hepatitis is a significant risk factor of HCC recurrence following hepatectomy (22). Notably, the expression of LYVE-1 in the lymphatic endothelium is downregulated by the pro-inflammatory cytokine tumor necrosis factor-α in vitro and in vivo (23)(24)(25), suggesting that LYVE-1 expression may be suppressed by hepatitis. The fact that inflammation is initiated early during the course of liver disease is consistent with our hypothesis that LYVE-1 may be an early marker of HCC tumorigenesis.…”

Section: Univariate Analysis ----------------------------------------mentioning

confidence: 98%

Lymphatic vessel endothelial hyaluronan receptor-1 is a novel prognostic indicator for human hepatocellular carcinoma

Kitagawa

Nakajima

Kuramochi

et al. 2013

Molecular and Clinical Oncology

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Abstract. Angiogenesis is an important mechanism of tumor development, growth and metastasis in hepatocellular carcinoma (HCC). The poor prognosis of HCC patients has been associated with a failure to detect recurrences following surgery. In the present study, we investigated the association between the patient characteristics and the expression of angiogenic genes to identify early biomarkers of HCC. A comprehensive angiogenic gene expression profile was obtained by paired TaqMan gene array analysis of primary HCC nodules and adjacent non-HCC liver tissue from 12 patients. A total of 14 genes were found to be differentially expressed in HCC liver nodules (>2-fold change); the genes encoding collagen type XVα1, IVα1 and IVα2 were upregulated and the genes associated with vessel growth, neuropilin 2 (NRP2) and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) were downregulated. The histopathological analysis revealed that the evolution of HCC nodules from well to poorly differentiated was associated with a 5-fold decrease in LYVE-1 expression, reaching its lowest level early during the transition. The significance of this gene as a biomarker of postoperative survival was demonstrated by a 2-fold decrease in overall survival (OS) rates in the low expression group compared to the high expression group. The multivariate and univariate Cox regression analyses identified LYVE-1 expression as a significant independent prognostic parameter of OS [hazard ratio (HR)=3.067; 95% confidence interval (CI): 1.507-6.273; P=0.0021]. Thus, the results of this study suggested that LYVE-1 expression may constitute a novel early biomarker of postoperative survival in HCC patients.

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Tumor Necrosis Factor-α Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells

Cited by 78 publications

References 66 publications

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

The ubiquitous hyaluronan: Functionally implicated in the oviduct?

Lymphatic vessel endothelial hyaluronan receptor-1 is a novel prognostic indicator for human hepatocellular carcinoma

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