Tumor necrosis factor-α elevates neurite outgrowth through an NF-κB-dependent pathway in cultured adult sensory neurons: Diminished expression in diabetes may contribute to sensory neuropathy

Saleh, Anas; Smith, Daniel R.; Balakrishnan, Savitha; Dunn, L.M.; Martens, Corina; Tweed, Christopher W.; Fernyhough, Paul

doi:10.1016/j.brainres.2011.09.029

Cited by 37 publications

(30 citation statements)

References 53 publications

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“…Next, we performed studies by inhibiting NF-B transcriptional activity with the peptide inhibitor SN50, which blocks movement of the p50 active transcription complex of NF-B into the nucleus. It is known in embryonic and adult DRG neurons that survival and axonal growth require activation of the p50 and p65 dimers of NF-B (6,9,26). We have shown that CVS infection and SN50 (30 g/ml) exert an additive effect in producing axonal swellings with 4-HNE-labeled puncta and in inhibiting axonal outgrowth in the cultures.…”

Section: Figmentioning

confidence: 83%

Role of Nuclear Factor-κB in Oxidative Stress Associated with Rabies Virus Infection of Adult Rat Dorsal Root Ganglion Neurons

Kammouni

Hasan

Saleh

et al. 2012

J Virol

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Section: Figmentioning

confidence: 83%

Role of Nuclear Factor-κB in Oxidative Stress Associated with Rabies Virus Infection of Adult Rat Dorsal Root Ganglion Neurons

Kammouni

Hasan

Saleh

et al. 2012

J Virol

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“…For example, TNF-␣ levels and 884 NF-B signaling were decreased in dorsal root ganglia (DRG) obtained from rats that had a relatively moderate level of diabetes for 5 months (Saleh et al, 2011). Likewise, despite an increase in the expression of COX-2, TNF-␣ levels were decreased in the sciatic nerve of rats that manifested a tactile allodynia after 4 weeks of diabetes (Jolivalt et al, 2009).…”

Section: G Inflammation Lipid Mediators and Dyslipidemiamentioning

confidence: 99%

Diabetic Peripheral Neuropathy: Should a Chaperone Accompany Our Therapeutic Approach?

Farmer

Dobrowsky

2012

Pharmacol Rev

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“…Our results are in full agreement with Zanella et al (2008) and Dogrul et al (2011), who reported on improvement in thermal hyperalgesia with etanercept (TNF-α-antibodies). In contrast, recently, it has been reported that TNF-α elevates neurite outgrowth through an NF-κB-dependent pathway in cultured adult sensory neurons, and the diminished expression of TNF-α in diabetes may contribute to sensory neuropathy (Saleh et al 2011). …”

Section: Discussionmentioning

confidence: 94%

Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain

Chauhan

Taliyan

Sharma

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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Diabetic neuropathy is recognized as one of the most common complications of chronic diabetes, but its pathophysiological mechanism is complex and yet to be completely explored. Monotherapy with conventional analgesics fails to provide adequate pain relief in peripheral diabetic neuropathy. There are a number of evidence suggesting that tumor necrosis factor (TNF-α) plays an important role in the pathogenesis of peripheral diabetic neuropathy. TNF-α up-regulation activates nuclear factor κB, which further up-regulates cyclooxygenase (COX)-2 leading to altered prostaglandin profile. Inhibition of TNF-α and COX-2 provides beneficial effect on diabetic neuropathy by decreasing the oxidative stress level and by preventing neuronal hypersensitivity due to an increased prostaglandin level. The present study was designed to assess the effect of dipyrone and thalidomide on streptozotocin (STZ)-induced neuropathic pain behavior in rats. STZ 50 mg/kg, i.p. was administered to induce experimental diabetes in the rats. Three weeks following STZ, dipyrone (300 and 600 mg/kg, i.p.) and thalidomide (25 and 50 mg/kg, i.p.) alone and subeffective dose combination of dipyrone and thalidomide (300 and 25 mg/kg(-1), i.p.) administered daily for 2 weeks significantly attenuated thermal hyperalgesia, mechanical allodynia, and formalin-induced phase-2 flinching response. Moreover, the subeffective dose combination of dipyrone and thalidomide and preemptive treatment with thalidomide (50 mg/kg) reduces oxidative stress in diabetic rats. In conclusion, the combination of subeffective dose of dipyrone and thalidomide prevented the development and maintenance of experimental diabetic neuropathy. The combination of thalidomide (TNF-α inhibitor) and dipyrone (COX inhibitor) may be used as a potential therapeutic agent for the treatment of diabetic neuropathy.

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Tumor necrosis factor-α elevates neurite outgrowth through an NF-κB-dependent pathway in cultured adult sensory neurons: Diminished expression in diabetes may contribute to sensory neuropathy

Cited by 37 publications

References 53 publications

Role of Nuclear Factor-κB in Oxidative Stress Associated with Rabies Virus Infection of Adult Rat Dorsal Root Ganglion Neurons

Role of Nuclear Factor-κB in Oxidative Stress Associated with Rabies Virus Infection of Adult Rat Dorsal Root Ganglion Neurons

Diabetic Peripheral Neuropathy: Should a Chaperone Accompany Our Therapeutic Approach?

Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain

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