Tumor necrosis factor-α and diabetic retinopathy: Review and meta-analysis

Yao, Yang; Li, Rong; Du, Junhui; Li, Xiangnan; Zhao, Lei; Long, Lihui; Li, Dongmin; Lu, Shemin

doi:10.1016/j.cca.2018.06.028

Cited by 25 publications

(15 citation statements)

References 30 publications

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“…We chose six markers based on their suggested involvement in DM / DR (CRP, IL-1β, IL-6, TNFα, sICAM1, and sVCAM1) and showed that all of them are significantly elevated in blood of subjects with diabetes compared to healthy controls, both in type 1 and type 2 DM, in line with previously published reviews and meta-analyses. 25 , 27 , 28 Although statistical significance was not reached for each DR comparison in this population-based analysis, all the tested analytes showed a trend of increased blood levels with increasing retinopathy severity, partially confirming published data 29 – 31 , 37 on a bigger dataset, mainly coming from patients with type 2 DM. As expected, larger SMDs were observed when comparing more diverse and extreme groups (DM versus Cntrl, no DR versus Cntrl, and PDR versus no DR) than when considering comparisons within a more homogeneous population (NDPR versus no DR and PDR versus NPDR).…”

Section: Discussionsupporting

confidence: 82%

“…In particular, C-reactive protein (CRP) is produced by the liver and considered a biomarker of systemic inflammation, type 2 DM, and risk of cardiovascular disease. 35 , 36 IL-6 and TNFα are potential biomarkers of DR 31 , 37 and, together with interleukin 1β (IL-1β), may contribute to the pathological mechanism of DR (reviewed in Ref. 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy

Storti

Pulley

Kuner

et al. 2021

Trans. Vis. Sci. Tech.

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Inflammation and endothelial activation play a pivotal role in development and progression of diabetic retinopathy (DR), a vision-threatening complication of diabetes mellitus (DM) and the leading cause of blindness in the working age population. Easily accessible and validated biomarkers for DR early diagnosis and progression are required for use in clinical trials: here, we reviewed the available literature to understand the association of circulating levels of selected markers of inflammation and endothelial activation with the presence of nonproliferative and proliferative DR (NPDR and PDR) and investigate the relationship between their systemic and ocular levels. We additionally provide data synthesis and perform statistical analysis for interpretation of the collected evidence. CRP, IL-1β, IL-6, TNFα, sICAM1, and sVCAM1 circulating levels were increased in subjects with DM compared to healthy individuals. Moreover, TNFα and sVCAM1 showed increasing systemic levels with DR presence and severity; circulating CRP increased with the transition from no DR to NPDR, whereas IL-6 was increased in PDR compared to NDPR stages. The relationship between ocular and systemic concentrations of these proteins remained unclear due to the low number of studies with matched sampling. In conclusion, the available data supports the use of systemic biomarkers of inflammation and endothelial activation to identify DM status and DR severity. These systemic biomarkers are likely reflecting an overall state of inflammation and vascular activation in different tissues of the body, including the eyes. Prospective, longitudinal datasets are required to validate these biomarkers as predictors of early DR presence, of DR progression, or for disease monitoring.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy

Storti

Pulley

Kuner

et al. 2021

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

show abstract

“…Increased levels of TNF-α have been found in PDR. A study of meta-analysis indicated that the level of TNF-α in DR patients was significantly different from that in healthy controls ( 77 ). There is a strong correlation between plasma TNF-α levels and the severity of ( 78 ).…”

Section: Inflammation and Endothelial Dysfunction Of Drmentioning

confidence: 99%

Endothelial Dysfunction in Diabetic Retinopathy

Gui

You

et al. 2020

Front. Endocrinol.

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Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and receptors, pro-inflammatory cytokines and chemokines, proliferator-activated receptor-γ disruption, growth factors, oxidative stress, and microRNA. These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.

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“…IL-8 plays an important role in ocular inflammation and angiogenesis 28. PDR is considered a chronic inflammatory condition,29–36 and exposure to these proinflammatory cytokines for months may affect the retinal thickness changes in SO-filled eyes with PDR.…”

Section: Discussionmentioning

confidence: 99%

Biological Characteristics of Subsilicone Oil Fluid and Differences With Other Ocular Humors

Shimizu

Kaneko

Suzumura

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: Subsilicone oil fluid (SOF) in eyes with silicone oil (SO) endotamponade possibly has a role in complications (e.g., vision loss); thus, we aimed to examine inflammatory cytokine and electrolyte levels and retinal glial cell viability in SOF. Methods:We measured major inflammatory cytokine levels and electrolytes in SOF and compared them with those in vitreous fluid (VF) and anterior chamber fluid (ACF). We analyzed the correlation between inflammatory cytokines and retinal thickness in SO-filled eyes. Further, we measured the MIO-M1 cell viability in medium with SOF and compared it with that containing VF.Results: We collected and examined 57 SOF, 22 ACF, and 21 VF samples from eyes with PVR, PDR, RD, and MH. Interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 levels in SOF were significantly higher than those in ACF. There was no significant difference for all cytokines between SOF and VF. Retinal thickness changes during SO endotamponade were not correlated with the presence of any inflammatory cytokines. Levels of ferrous iron, but not of potassium, showed a significant decrease in SOF compared with VF. The WST-1 assay showed that SOFadded medium induced higher MIO-M1 cell viability than VF-added medium. Conclusions:We found no significant correlation between the change in the retinal thickness and cytokine levels, but SOF contains higher concentrations of cytokines and lower concentrations of ferrous iron and can be biologically distinguished from ACF and VF.Translational Relevance: Novel knowledge of inflammatory cytokine levels and electrolytes in SOF provides better understanding of pathology of SO-filled eyes.

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Tumor necrosis factor-α and diabetic retinopathy: Review and meta-analysis

Cited by 25 publications

References 30 publications

Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy

Circulating Biomarkers of Inflammation and Endothelial Activation in Diabetic Retinopathy

Endothelial Dysfunction in Diabetic Retinopathy

Biological Characteristics of Subsilicone Oil Fluid and Differences With Other Ocular Humors

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