Endothelial Dysfunction in Diabetic Retinopathy

Gui, Fu; You, Zhipeng; Fu, Su; Wu, Hongxi; Zhang, Yulan

doi:10.3389/fendo.2020.00591

Cited by 100 publications

(77 citation statements)

References 209 publications

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“…[10] Endo-Pat is of great significance for screening of high-risk population and has gradually been set as a clinical function evaluation indicator of vascular aging. [11,12] Infrared thermal imaging technology Infrared thermography, based on the principle of remote temperature measurement, records the infrared radiation wavelength emitted by human skin (affected by skin vascular relaxation and contraction factors) to analyze the multiple information of body surface temperature, and displays it in the form of thermal map, so as to reflect the microcirculation, the blood circulation of the lesion site, etc. [13] The study found that infrared thermal imaging technology has unique value in screening large population, detecting vascular function of chronic diseases such as hypertension, diabetes, and theirs complications.…”

Section: Journal Of Translational Internal Medicine / Aopmentioning

confidence: 99%

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Progress of clinical evaluation for vascular aging in humans

Qiu

Liu

Tao

2021

Journal of Translational Internal Medicine

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Human society is experiencing a serious aging process. Age-related arteriosclerotic cardiovascular diseases (ASCVD) are the most common cause of deaths around the world and bring a huge burden on the whole society. Vascular aging-related pathological alterations of the vasculature play an important role in the pathogenesis of ASCVD and morbidity and mortality of older adults. In this review, we describe the progress of clinical evaluation of vascular aging in humans, including functional evaluation, structural assessment, and cellular molecular markers. The significance of detection for vascular aging is highlighted, and we call for close attention to the evaluation for a better quality of life in the elderly population.

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Section: Journal Of Translational Internal Medicine / Aopmentioning

confidence: 99%

“…[ 10 ] Endo-Pat is of great significance for screening of high-risk population and has gradually been set as a clinical function evaluation indicator of vascular aging. [ 11 , 12 ]…”

Section: Functional Evaluation Of Vascular Agingmentioning

confidence: 99%

Progress of clinical evaluation for vascular aging in humans

Qiu

Liu

Tao

2021

Journal of Translational Internal Medicine

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“…The underlying molecular mechanisms associated with vascular dysfunction, especially endothelial dysfunction, in DR are multifactorial. Chronic inflammation, oxidative stress, leukostasis, dysregulated growth factors and cytokines, and disruption of peroxisome proliferator-activated receptor-γ are mainly involved [ 98 ]. Diabetic retinopathy is prevalent in around 35% of patients with diabetes.…”

Section: Ocular Neurodegenerative Diseasesmentioning

confidence: 99%

Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas

Marchesi

Fahmideh

Boschi

et al. 2021

Cells

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The possible interconnection between the eye and central nervous system (CNS) has been a topic of discussion for several years just based on fact that the eye is properly considered an extension of the brain. Both organs consist of neurons and derived from a neural tube. The visual process involves photoreceptors that receive light stimulus from the external environment and send it to retinal ganglionic cells (RGC), one of the cell types of which the retina is composed. The retina, the internal visual membrane of the eye, processes the visual stimuli in electric stimuli to transfer it to the brain, through the optic nerve. Retinal chronic progressive neurodegeneration, which may occur among the elderly, can lead to different disorders of the eye such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). Mainly in the elderly population, but also among younger people, such ocular pathologies are the cause of irreversible blindness or impaired, reduced vision. Typical neurodegenerative diseases of the CSN are a group of pathologies with common characteristics and etiology not fully understood; some risk factors have been identified, but they are not enough to justify all the cases observed. Furthermore, several studies have shown that also ocular disorders present characteristics of neurodegenerative diseases and, on the other hand, CNS pathologies, i.e., Alzheimer disease (AD) and Parkinson disease (PD), which are causes of morbidity and mortality worldwide, show peculiar alterations at the ocular level. The knowledge of possible correlations could help to understand the mechanisms of onset. Moreover, the underlying mechanisms of these heterogeneous disorders are still debated. This review discusses the characteristics of the ocular illnesses, focusing on the relationship between the eye and the brain. A better comprehension could help in future new therapies, thus reducing or avoiding loss of vision and improve quality of life.

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“…AGE binding to RAGE receptors upregulates cyclooxygenase-2 (COX), resulting in monocyte activation and vascular cell dysfunction [79], linked to oxidative stress and NF-κB activation [80,81]. Finally, AGEs have been shown to stimulate endothelial cell proliferation and angiogenesis by upregulation of VEGF and via the RhoA/Rhoassociated protein kinase pathway [82,83].…”

Section: Receptor For Advanced Glycation End Products (Rage)mentioning

confidence: 99%

Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World

Bhatwadekar

Shughoury

Belamkar

et al. 2021

Genes

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Diabetic retinopathy (DR) is a chronic complication of diabetes and a leading cause of blindness in the industrialized world. Traditional risk factors, such as glycemic control and duration of diabetes, are unable to explain why some individuals remain protected while others progress to a more severe form of the disease. Differences are also observed in DR heritability as well as the response to anti-vascular endothelial growth factor (VEGF) treatment. This review discusses various aspects of genetics in DR to shed light on DR pathogenesis and treatment. First, we discuss the global burden of DR followed by a discussion on disease pathogenesis as well as the role genetics plays in the prevalence and progression of DR. Subsequently, we provide a review of studies related to DR’s genetic contribution, such as candidate gene studies, linkage studies, and genome-wide association studies (GWAS) as well as other clinical and meta-analysis studies that have identified putative candidate genes. With the advent of newer cutting-edge technologies, identifying the genetic components in DR has played an important role in understanding DR incidence, progression, and response to treatment, thereby developing newer therapeutic targets and therapies.

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Endothelial Dysfunction in Diabetic Retinopathy

Cited by 100 publications

References 209 publications

Progress of clinical evaluation for vascular aging in humans

Progress of clinical evaluation for vascular aging in humans

Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas

Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World

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