Tumor necrosis factor-α –863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery

Abstract

The current study suggests that the major -863 CC variant determines elevated TNF-α level preoperatively and throughout the postoperative course after CPB.

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

“…This finding was supported by Yoon et al, who also observed elevated TNF-a levels after cardiac surgery in patients carrying the TNF-a-308 G4A GA or AA allele in a Korean population. 36 Although we could not validate those findings for the TNF-a-308 G4A polymorphism in a Caucasian population, 32 we found another genetic variant in the promoter region of the TNF-a gene associated with postoperative TNF-a levels underscoring the genetic status of the promoter region of the TNF-a gene. Furthermore, Yende et al found in 400 patients undergoing cardiac surgery, that the haplotypes of the Lymphotoxin-a-250 G/TNF-a308 G carry a higher risk for prolonged mechanical ventilation after surgery.…”

“…30,31 There is increasing evidence that inter-individual differences in TNF-a productions are caused by genetic variability. 8,14,27,29,[32][33][34] Nevertheless, the clinical impact of those genetic variants needs validation in large cohorts. This study investigates in a large, prospectively enrolled patient cohort whether the individual variability in the ApoE (E2,E3,E4) genotype or TNFa-308 G4A has an influence on the development of postoperative CSA-AKI.…”

The dynamics of inflammatory factors in the early postoperative period after various techniques of coronary artery bypass grafting

“…Данные повреждения играют роль в формирова-нии станнинга миокарда. Была показана роль данного медиатора в запуске процесса апоптоза посредством TNF-рецепторов мембран кардиомиоцитов 1-го и 2-го типов [8][9][10].…”

The importance of genetic polymorphism of inflammatory response mediators in the development of complications after cardiac surgery (literature review)

“…Boehem и соавт. [6] изучали влияние двух SNP в промотерном регионе гена TNF-α -863С/А и -308G/A на уровни TNF-α у пациентов после операции АКШ, выпол-ненной с применением ИК. Установлено достоверное влияние полиморфизма -863С/А: распространенный ге-нотип -863СС сочетался с более высокими уровнями TNF-α до операции (р=0,003), сразу после завершения ИК (р=0,005) и через 6 ч после операции (р=0,01) независи-мо от времени ИК, функции левого желудочка (ЛЖ) и возраста пациентов.…”