The dynamics of inflammatory factors in the early postoperative period after various techniques of coronary artery bypass grafting

Buziashvili, Yu. I.; Koksheneva, I. V.; Samsonova, N. N.; Abukov, S. T.; Buziashvili, V. Yu.; Климович, Л.Г.

doi:10.17116/kardio2015814-11

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Так, в 1-й подгруппе коэффициент ИФН-γ/ИЛ-4 увеличивается с 8,3 до 13,5, а во 2-й подгруппе уменьшается более чем в два раза по сравнению с исходными значениями. Полученные данные согласуются с результатами литературных источников, в которых отмечается повышение провоспалительных цитокинов у пациентов, перенесших КШ с осложнениями в виде нарушения мозгового кровообращения и когнитивной дисфункции, а также осложнениями со стороны сердечно-сосудистой системы [4,10].…”

Section: таблица 3 динамика содержания цитокинов и эндотелина-1 у паunclassified

“…В литературе встречаются данные, отражающие роль таких цитокинов, как ФНО-α, ИЛ-6, ИЛ-10, ИЛ-1, в развитии послеоперационных осложнений у пациентов, перенесших КШ. Однако данные работы ограничены весьма коротким периодом наблюдения после КШ (от 2 до 24 часов) и не отражают истинной картины цитокиновой активности и эндотелиальной функции, а также носят противоречивый характер [4]. Кроме того, отсутствуют данные о взаимодействии ИЛ-4 и ИФН-γ как мощных регуляторов воспалительного ответа в различные сроки наблюдения после КШ.…”

Section: Introductionunclassified

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Cytokine Profile and Endothelial Status in Patients with Coronary Artery Disease and Different Outcomes of Coronary Artery Bypass Grafting

Шлык

2019

Kuban. nauсh. med. vestnik

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Aim. To assess the cytokine profile and the level of endothelial dysfunction in patients with coronary artery disease (CAD) and different outcomes of coronary artery bypass grafting (CABG).Materials and methods. The study included 95 people, with 22 of them being practically healthy (without CAD). The CAD patients (73) were retrospectively divided into 2 subgroups according to the presence of complications within the first month after the CABG. The first subgroup consisted of 25 patients suffering from complications after CABG, with 48 people making up the second subgroup (no complications after CABG). CABG was performed on a beating heart; bypass grafts were attached during revascularisation. The serum levels of IL-4 and IFN-γ were determined through the enzyme-linked immunosorbent assay (ELISA) using appropriate test systems manufactured by BCM Diagnostics and a Zenyth 340 microplate photometer (Biochrom Ltd). In order to determine the content of endothelin-1 in blood serum, ELISA test systems manufactured by Biomedica were used. The statistical analysis of study results was performed employing the descriptive statistics module of Statistica 12.0 (StatSoft, USA). The mean (M), its error (m), median (Me) and the interquartile range [Q25; Q75] were calculated. In cases when p ≤ 0.05, the results were considered statistically significant.Results. It was revealed that, in the preoperative period, CAD patients from both subgroups exhibited increased levels of endothelin-1 (p = 0.0001) and IFN-γ (p = 0.0001), whereas an increase in IL-4 production was noted only in the first subgroup (p = 0.0001), as compared to the control group. The follow-up revealed that CAD patients with complications after CABG exhibited stable high levels of IL-4 (p > 0.05) and IFN-γ (p > 0.05) during the entire observation period, as compared to the initial values. The content of endothelin-1 in both subgroups increased significantly on the 4th day of observation (p > 0.05) and returned to its initial high values after 1 month.Conclusion. Immune response in CAD patients suffering from complications after CABG develops mainly along the pro-inflammatory pathway and is accompanied by endothelial dysfunction.

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Section: таблица 3 динамика содержания цитокинов и эндотелина-1 у паunclassified

Section: Introductionunclassified

Cytokine Profile and Endothelial Status in Patients with Coronary Artery Disease and Different Outcomes of Coronary Artery Bypass Grafting

Шлык

2019

Kuban. nauсh. med. vestnik

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Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load

et al. 2017

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Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, GTFβ on the structure and metabolism of contractile ventricular cardiomyocytes was assessed in the control and under conditions of acute experimental aortic stenosis. Systemic administration of the complex in the control had no significant effect on myocardial morphology with low number of damaged cardiomyocytes and low degree of structural damage. Administration of the cytokine complex against the background of aortic stenosis did not exert any additional alterative effect on cardiomyocytes, structural damage of contractual nature was moderate. Systemic administration of the natural cytokine complex had a pronounced inhibitory effect on metabolic processes in the myocardium of both ventricles both in the control and against the background of increased hemodynamic load. In cardiomyocytes, glycolysis and citric acid cycle were slowed down, oxidation of free fatty acids and their metabolic products was inhibited as well as shuttle mechanisms and biosynthetic reactions. Inhibition of energy-producing processes is the cause of the lack of the contractile function energy supply and can worsen the course of cardiovascular diseases and increase the risk of their complications in conditions, accompanied by increased blood cytokine level.

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Effect of Natural Cytokine Complex on Metabolism of Smooth Muscle Cells in Myocardial Arteries under Normal Conditions and during Hemodynamic Overload

et al. 2020

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The dynamics of inflammatory factors in the early postoperative period after various techniques of coronary artery bypass grafting

Cited by 7 publications

References 20 publications

Cytokine Profile and Endothelial Status in Patients with Coronary Artery Disease and Different Outcomes of Coronary Artery Bypass Grafting

Cytokine Profile and Endothelial Status in Patients with Coronary Artery Disease and Different Outcomes of Coronary Artery Bypass Grafting

Effect of the Natural Cytokine Complex on the Structure and Metabolism of Contractile Myocardium Normally and under Increased Hemodynamic Load

Effect of Natural Cytokine Complex on Metabolism of Smooth Muscle Cells in Myocardial Arteries under Normal Conditions and during Hemodynamic Overload

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