Tumor Necrosis Factor α −308 G&gt;A Polymorphisms and Cervical Cancer Risk

Ding, Bo; Fu, Shilong; Wang, Meilin; Yue, Cong; Wang, Wei; Zhou, Detang; Zhang, Zhengdong; Han, Song

doi:10.1097/igc.0b013e3182375aed

Cited by 22 publications

(11 citation statements)

References 25 publications

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“…For HPV-associated cancer, several studies have reported that the minor A allele of SNP-308 represents an increased risk of HPV infection and HPV-associated cervical cancer from various ethnic groups [17,29]. A meta-analysis based on 2298 cases of cervical cancer and 1903 controls from eight study populations showed a summary OR of 1.31 (95% CI, 1.14–1.52); that analysis compared individuals carrying the GA/AA genotypes with those carrying the GG genotype of TNF - α -308, in which further stratification analysis by ethnicity showed that the risk remained significant among both Caucasians and Asians [30]. …”

Section: Discussionmentioning

confidence: 99%

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

et al. 2013

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BackgroundTumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility to HPV-associated oral squamous cell carcinoma (OSCC).MethodsIn this study we genotyped four common single nucleotide polymorphisms (SNPs) in the TNF-α promoter [ −308G > A(rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964)] and determined HPV16 serology in 325 OSCC cases and 335 matched controls and tumor HPV status in 176 squamous cell carcinomas of the oropharynx (SCCOP) patients. Univariate and multivariable logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsWe found that HPV16 seropositivity alone was associated with an increased risk of OSCC (OR, 3.1; 95% CI, 2.1–4.6), and such risk of HPV16-associated OSCC was modified by each SNP. Patients with both HPV16 seropositivity and variant genotypes for each SNP had the highest risk when using patients with HPV16 seronegativity and a wild-type genotype as a comparison group. Moreover, similar results were observed for the combined risk genotypes of four variants and all such significant associations were more pronounced in several subgroups, particularly in SCCOP patients and never smokers. Notably, the combined risk genotypes of four variants were also significantly associated with tumor HPV-positive SCCOP.ConclusionTaken together, these results suggest that TNF-α SNPs may individually or, more likely, jointly affect individual susceptibility to HPV16-associated OSCC, particularly SCCOP and never smokers. Validation of our findings is warranted.

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Section: Discussionmentioning

confidence: 99%

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

et al. 2013

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“…Furthermore, it was shown that high levels of TNF‐α contributed to monocyte differentiation into mature dendritic cells (DCs) in CC. TNF‐α is the most important pro‐inflammatory cytokine which is produced by macrophages and monocytes, playing both anticarcinogenic and procarcinogenic roles . Mutations in the A allele and the GA/AA single nucleotide polymorphism in TNF‐> j308 have been demonstrated as risk factors for CC development .…”

Section: Inflammation and CCmentioning

confidence: 99%

“…49,50 Mutations in the A allele and the GA/AA single nucleotide polymorphism in TNF-> j308 have been demonstrated as risk factors for CC development. 50 Another cytokine, IL-6, is associated with persistent HPV infection and with the progression of CC. IL-6 activates the signal transducer and activator of transcription 3 (STAT3) oncogene, which contributes to chronic inflammation in CC.…”

Section: Inflammation and CCmentioning

confidence: 99%

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Nahand

Moghoofei

Salmaninejad

et al. 2019

Intl Journal of Cancer

179

108

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Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of noncoding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological processes, including inflammatory pathways. Abnormal expression of miRNAs may be linked to the induction of inflammation that occurs in CC. Exosomes are a subset of extracellular vesicles shed by almost all types of cells, which can function as cargo transfer vehicles. Exosomes contain proteins and genetic material (including miRNAs) derived from their parent cells and can potentially affect recipient cells. Exosomes have recently been recognized to be involved in inflammatory processes and can also affect the immune response. In this review, we discuss the role of HPV proteins, miRNAs and exosomes in the inflammation associated with CC.

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“…Moreover, many researches about TNF-α −308 polymorphism and other kinds of cancer risk were conducted and yielded the association in the same direction. Two meta-analyses performed by Ding et al [57] and Zhang et al [58] successively observed the increased cervical cancer with TNF-α −308 polymorphism. Hong et al [59] demonstrated that TNF-α −308 polymorphism increased the risk of developing gastric cancer in a Chinese, and the polymorphism of interest was also shown to increase breast cancer risk among Caucasian in a meta-analysis by Fang [60]; however, a meta-analysis failed to found an association with nasopharyngeal carcinoma perhaps due to the small sample size and limited statistical power [61].…”

Section: Discussionmentioning

confidence: 97%

The association between the polymorphisms of TNF-α and non-Hodgkin lymphoma: a meta-analysis

Zhu

Huang

et al. 2014

Tumor Biol.

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Many genetic variations in the promoter region of tumor necrosis factor alpha (TNF-α) may confer host susceptibility to cancer by influencing TNF-α expression. Nevertheless, the results remain inconclusive. The current meta-analysis was performed to investigate the association between three common TNF-α promoter polymorphisms and the risk of non-Hodgkin lymphoma (NHL). A literature search was conducted mainly from PubMed for all eligible studies. The pooled odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to assess the association of TNF-α polymorphisms with the risk of NHL. TNF-α -308 A allele showed a statistically significant increased risk for NHL under the homozygous (AA vs. GG, OR = 1.51, 95 % CI = 1.26-1.80) and recessive (OR = 1.47, 95 % CI = 1.23-1.75) models, respectively. The stratified analyses showed an increased risk of NHL with the presence of TNF-α -308 A allele among Africans and Caucasians, but a decreased risk among Asians. No association was observed between -238 G/A polymorphism and NHL risk either in the overall analysis or in the stratified analysis. Similarly, pooled analysis did not reveal an altered risk of NHL with -857 C/T polymorphism. Nonetheless, a statistically significant association was observed among Asians when stratified by ethnicity. Among the three genetic variations of interest, TNF-α -308 G/A polymorphism was significantly associated with the risk of NHL; neither -238 G/A nor -857 C/T polymorphism was shown to alter the overall NHL risk; however, stratified analysis by ethnicity observed a statistically significant association between -857 C/T polymorphism and the risk of NHL among Asians.

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Tumor Necrosis Factor α −308 G>A Polymorphisms and Cervical Cancer Risk

Abstract: The natural genetic polymorphism in TNF-α -308 G>A is a risk factor for developing cervical cancer, especially for Asians and whites.

Cited by 22 publications

References 25 publications

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

The association between the polymorphisms of TNF-α and non-Hodgkin lymphoma: a meta-analysis

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