Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to HPV infection in patients with and without cervical intraepithelial lesion

Tavares, Mayara Costa Mansur; Júnior, Sérgio Ferreira de Lima; Coelho, Antônio Victor Campos; Marques, Trícia Ruschelle N M; Araújo, Diêgo Henrique T de; Heráclio, Sandra de Andrade; Amorim, Melânia Maria Ramos; Souza, Paulo Roberto Eleutério de; Crovella, Sérgio

doi:10.3109/03014460.2014.1001436

Cited by 20 publications

(10 citation statements)

References 58 publications

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“…Then, our samples were tested for HPV presence using MY09/11, GP05+ and GP06+ consensus primers by polymerase chain reaction (PCR) ( Tavares et al 2014 ). The typing of high-risk HPV (HR-HPV) 16, 18, 31, and 33 was performed using specific primers (da Silva et al 2009 , Tavares et al 2015 ).…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

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CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Santos

Lima

Oliveira

et al. 2016

Mem. Inst. Oswaldo Cruz

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Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.

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Section: Subjects Materials and Methodsmentioning

confidence: 99%

“…Sequencing - A total of 20% of the all samples (randomly chosen) was submitted to bidirectional sequencing (MegaBACE 1000 DNA sequencer; GE Healthcare, USA) in order to double-check the genotyping results for each polymorphism ( Tavares et al 2015 ).…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Santos

Lima

Oliveira

et al. 2016

Mem. Inst. Oswaldo Cruz

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“…These differences suggest that there are mechanisms that reduce the expression of IL-18 in the infection and progression of HPV-induced lesions. In uterine cervix cancer, there are some IL-18 polymorphisms that have been linked to cancer progression (Tavares et al, 2016) and it has been found that a reduction of plasma IL-18 increases the risk of developing cervical cancer (Gening et al, 2014). Similar results were found in HeLa, Caski cells, monocytes and HPV-16 tumor associated macrophages (Cho et al, 2001;Lee et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Reduced Expression of IL-1β and IL-18 Proinflammatory Interleukins Increases the Risk of Developing Cervical Cancer

Matamoros

Silva

Moura

et al. 2019

Asian Pac J Cancer Prev

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Background: The objective of this study was to analyze the gene expression profile of the proinflammatory interleukins, (IL-1β and IL-18) in patients with premalignant lesions and cervical cancer. Methods: Total IL-1β and IL-18 mRNA was quantified by qPCR to obtain the expression data in cervical tissues. A total of 74 cervical biopsies were obtained from women undergoing a colposcopy. The samples were divided into: normal (19), low level lesions (LSIL) or NIC I (17), high level lesions (HSIL) or CIN II and CIN III (29) and cancer (9). The normal cervical tissue samples were included as controls. The OR and 95% CI were calculated for the determination of the risk of progression between each type of lesion and cancer using logistic regression. Results: The results showed that an increase in the risk of progression of pre-neoplastic lesions to cancer was between 2.5 and 2.08 times higher in women with lower IL-1β and IL-18 expression, respectively. Conclusions: This study provided evidence that IL-1β and IL-18 are potential biomarkers that can be explored in further studies for monitoring the evolution of pre-neoplastic lesions and avoiding overtreatment or undertreatment of the patients.

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“…On the other hands, less clear is the contribution of the axis NLRP3/IL-18 in these diseases. Several variants were described within the IL-18 promoter region, leading to reduced IL-18 plasma levels, and conferring augmented susceptibility to HIV-1 [ 64 , 65 ] and tuberculosis [ 66 ], and protection against HPV infection [ 67 ].…”

Section: Infectious Diseasesmentioning

confidence: 99%

Inflammasome genetics and complex diseases: a comprehensive review

et al. 2020

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The inflammasome is a cytoplasmic multiprotein complex responsible for the activation of inflammatory caspases (caspase-1, -4, and -5) in response to pathogen- and/or damage-associated molecular patterns or to homeostasis-altering molecular pathways, and for the consequent release of the pro-inflammatory cytokines interleukin (IL)-1ß and IL-18. Taking in account the complexity of inflammasome activation and that several regulatory steps are involved in maintaining its physiologic role in homeostasis and innate immune response, it does not surprise that several genetic variants in inflammasome components have been associated with common pathologies in the general population, such as autoimmune disorders, cardiovascular diseases, obesity and associated metabolic syndrome, neurodegenerative diseases, and cancer. Moreover, the susceptibility to infectious agents and/or to develop severe complications during infections also has been related to inflammasome genetics. In this work, we revised genetic association studies about polymorphisms of main inflammasome genes in sterile as well as infectious diseases, trying to depict the genetic contribution of inflammasome in disease pathogenesis.

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Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to HPV infection in patients with and without cervical intraepithelial lesion

Abstract: The findings suggest an association between two TNFA SNPs and susceptibility to HPV infection in women from Northeast Brazil. The results need to be functionally validated and replicated in other populations with different ethnic backgrounds.

Cited by 20 publications

References 58 publications

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Reduced Expression of IL-1β and IL-18 Proinflammatory Interleukins Increases the Risk of Developing Cervical Cancer

Inflammasome genetics and complex diseases: a comprehensive review

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