Tumor Necrosis Factor-<i>α</i>as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis

Lv, Bokun; Huang, Jie; Yuan, Haining; Yan, Wenying; Hu, Guang; Wang, Jian

doi:10.1155/2014/471463

Cited by 34 publications

(29 citation statements)

References 33 publications

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“…High levels of IL-10 were associated with severity of NE and in those who received therapeutic hypothermia (TH). IL-10 also has neuroprotective properties demonstrated in animal studies (20) TNF-α is a proinflammatory cytokine which plays a critical role in the local inflammatory response and in initiation of the cytokine cascade (25). TNF-α is an important cytokine involved in sepsis and inflammation and is a potential marker in the diagnosis of early and late onset neonatal sepsis (25,26).…”

mentioning

confidence: 99%

Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy

Zareen

Strickland

Eneaney

et al. 2019

Preprint

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Objective: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age compared to age-matched controls. Method: Follow up at school age, children who had NE and age-matched controls were assessed for their cytokine responses and neurodevelopment outcome. Pro- and anti-inflammatory cytokines in the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α, TNF β, Interferon (IFN)-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), erythropoietin (EPO), IL-10 & IL-1RA] were measured at baseline and in response to in vitro stimulation with lipopolysaccharide (LPS: endotoxin). Results: GM-CSF, TNF-β, IL-2 IL-6, IL-8, IL-10, and IL-18 were significantly elevated at school age following NE (n=40) compared to controls (n=37). A significant rise in GM-CSF, IL-8, TNF-α, IL-1β, & IL-6 were seen in NE group following LPS stimulation. Relative LPS hypo-responsiveness was also noted in children with severe NE with IL-10, VEGF, EPO and TNF-β. Elevated TNF-β was associated with low gross motor scores on assessment at school age. Conclusion: School-age children post-NE had significantly altered cytokine responses to endotoxin compared to controls. TNF-β was associated with adverse developmental outcomes. This suggests the inflammatory process may persist into childhood and a longer therapeutic window may be available for immunomodulatory adjunctive therapies.

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mentioning

confidence: 99%

Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy

Zareen

Strickland

Eneaney

et al. 2019

Preprint

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“…TNF-α is a proinflammatory cytokine which plays a critical role in the local inflammatory response and in initiation of the cytokine cascade [27]. TNF-α is an important cytokine involved in sepsis and inflammation and is a potential marker in the diagnosis of early and late onset neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Cytokine dysregulation persists in childhood post Neonatal Encephalopathy

et al. 2020

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Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age compared to age-matched controls. Method: Follow up at school age, children who had NE and age-matched controls were assessed for their cytokine responses and neurodevelopment outcome. Pro-and anti-inflammatory cytokines in the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α, TNF β, Interferon (IFN)-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), erythropoietin (EPO), IL-10 & IL-1RA] were measured at baseline and in response to in vitro stimulation with lipopolysaccharide (LPS: endotoxin). Results: GM-CSF, TNF-β, IL-2 IL-6 and IL-8 were significantly elevated at school age following NE (n = 40) compared to controls (n = 37). A rise in GM-CSF, IL-8, TNF-α, IL-1β, & IL-6 were seen in NE group following LPS stimulation. Relative LPS hypo-responsiveness was also noted in children with severe NE with IL-10, VEGF, EPO and TNF-β. Elevated TNF-β was associated with low gross motor scores on assessment at school age. Conclusion: School-age children post-NE had significantly altered cytokine responses to endotoxin compared to controls. TNF-β was associated with adverse developmental outcomes. This suggests the inflammatory process may persist into childhood and a longer therapeutic window may be available for neuroprotection therapies.

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“…2 Possible correlations between TNF-α and IL-6 levels and EONS were analyzed by univariable test. Results with P values < 0.05 were considered to be statistically significant.…”

Section: Methodsmentioning

confidence: 99%

“…1,2 Bacterial infection in newborns may rapidly evolve into generalized sepsis. This condition has a gradual and subtle onset, with nonspecific symptoms that may severely compromise the infant's clinical state if untreated, and have life-threatening consequences.…”

mentioning

confidence: 99%

“…This condition has a gradual and subtle onset, with nonspecific symptoms that may severely compromise the infant's clinical state if untreated, and have life-threatening consequences. 2 Sepsis in neonates hospitalized in the neonatal intensive care unit (NICU) is a global problem and a significant contributor to morbidity and death. The incidence of neonatal sepsis in developed countries is 1 to 5 per 1,000 live births, while that in developing countries is higher, from 1.8 to 18 per 1,000 births of life.…”

mentioning

confidence: 99%

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