Tumor Necrosis Factor and the Disbalance Between Coagulant and Anticoagulant Mechanisms in Septicemia

Poll, Tom van der; Levi, Marcel; Deventer, Jörg

doi:10.1007/978-3-642-84423-2_31

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…The net effect of an injection of endotoxin or TNF-a is a procoagulant state. In this experimental model, coagulation and fibrinolysis seem to be activated independently, which may lead to an imbalance between activation of coagulation and regulation (activation/inhibition) of fibrinolysis [73]. The same imbalance has been observed in baboons after injection of IL-1 [74].…”

Section: Coagulation Activationmentioning

confidence: 84%

Review: Infectious Diseases and Coagulation Disorders

et al. 1999

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Infection, both bacterial and nonbacterial, may be associated with coagulation disorders, resulting in disseminated intravascular coagulation and multiorgan failure. In the last few decades a series of in vivo and in vitro studies has provided more insight into the pathogenetic mechanisms and the role of cytokines in these processes. Because of the growing interest in this field, the complexity of the subject, and the fact that many physicians must deal with a variety of infections, current data are reviewed on the association between infectious diseases and the coagulation system. Novel therapeutic intervention strategies that will probably become available in the near future are mentioned, along with those of special interest for infectious disorders for which only supportive care can be given.

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Section: Coagulation Activationmentioning

confidence: 84%

Review: Infectious Diseases and Coagulation Disorders

et al. 1999

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“…Limited data suggest that activation of coagulation and fibrinolysis play a role in the pathogenesis of DHF (Srichaikul et al , 1977; Bhamarapravati, 1989). An imbalance in the regulation of coagulation and fibrinolysis, as in the disseminated intravascular coagulation syndrome (DIC), in conjunction with the characteristic thrombocytopenia may contribute to the bleeding tendency in DHF and other VHFs (Van der Poll et al , 1990; Van Gorp et al , 1997).…”

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confidence: 99%

Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever

et al. 2001

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Summary. A prospective cohort study was performed in 50 patients with dengue haemorrhagic fever (DHF) to determine the potential role of the contact activation system and factor XI activation (intrinsic pathway) in the coagulation disorders in DHF. To establish whether TAFI (thrombinactivatable fibrinolysis inhibitor) was involved in the severity of the coagulation disorders, the TAFI antigen and activity levels were also determined. Markers of contact activation (kallikrein-C1-inhibitor complexes), the intrinsic pathway of coagulation (factor XIa±C1-inhibitor complexes) and TAFI were measured and correlated to thrombin generation markers (thrombin±anti-thrombin complexes (TAT), prothrombin fragment 112 (F112)) and a marker for fibrinolysis [plasmin±a2±anti-plasmin complexes (PAP)].Activation of the intrinsic pathway of coagulation was clearly demonstrated by elevated levels of factor XIa±C1-inhibitor complexes, without evidence of contact activation, reflected by undetectable kallikrein±C1-inhibitor complexes. Both TAFI antigen and activity levels were decreased in all patients, which may contribute to the severity of bleeding complications in DHF because of the impaired capacity of the coagulation system to protect the fibrin clot from fibrinolysis. These findings in a human viral infection model are in accordance with earlier findings in bacterial sepsis.

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Modulators of coagulation. A critical appraisal of their role in sepsis

Bone¹

1992

Archives of Internal Medicine

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Tumor Necrosis Factor and the Disbalance Between Coagulant and Anticoagulant Mechanisms in Septicemia

Cited by 8 publications

References 24 publications

Review: Infectious Diseases and Coagulation Disorders

Review: Infectious Diseases and Coagulation Disorders

Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever

Modulators of coagulation. A critical appraisal of their role in sepsis

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