Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B  (NF-kB) p65 and Calcineurin Expression play a role in the regulation of muscle regeneration process through aerobic exercise in HIV patients

Wulan, Sri Mardjiati Mei; P, Hening Laswati; Purnomo, Windhu; Pangkahila, Alex; Nasronudin, -; Hadi, Usman

doi:10.15562/bmj.v6i2.607

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased TNF-α gene expression may play a role in lipid and glucose metabolism in adipose tissue through the effects of autokrin and in skeletal muscle through the effects parakrinnya [31]. The increased TNF-α via the sport can contribute to the activation of satellite cells that trigger an increase in muscle fibers and establishment of regeneration of new induction through the expression of calcineurin [32]. Another issue to consider is that the role of TNF-α dependent on receptors in the cell membranes of the recipient, there are two types of receptors (TNFR1 and 2) and the pro-inflammatory characteristics commonly associated with protein (mainly in adipose tissue) is bonded with the TNFR 1 (Neto et al, 2015:578).…”

Section: Discussionmentioning

confidence: 99%

High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) Against TNF-α and IL-6 levels In Rats

Hadiono¹,

Kushartanti²

2019

Proceedings of the 2nd International Conference on Sports Sciences and Health 2018 (2nd ICSSH 2018)

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of exercise with High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) on inflammatory profile of proinflammatory cytokines TNF-α and IL-6 on the subject of obesity.This research is used 39 wistar rats of male-sex obesity. Intervention training is given for 6 weeks with frequency 4 times per week, HIIT intensity (90-100% of base line capability), MIT (60-80% of base line capability) TNF-α and IL-6 levels are obtained from blood testing with using ELISA test. Data analysis using Anova test.The results of this study showed that there were differences in levels of TNF-α HIIT with control (P = 0.003), MIT with control (P = 0.001) and no difference between HIIT group and MIT (P = 0.945). There was a difference of IL-6 levels between HIIT and control (P = 0.000), HIIT with MIT (P = 0.002), no difference in MIT group with control (P = 0.747). Exercise with the method of HIIT and MIT for 6 weeks with a frequency of 4 times per week can not create levels of TNF-α on the subject of obesity are lower as compared with sedentary groups, even the levels of TNF-α group of HIIT and MIT were significantly higher compared with the sedentary group. As for the levels of IL-6, HIIT is more effective in influencing the low IL-6 compared to MIT.

show abstract

Section: Discussionmentioning

confidence: 99%

High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) Against TNF-α and IL-6 levels In Rats

Hadiono¹,

Kushartanti²

2019

Proceedings of the 2nd International Conference on Sports Sciences and Health 2018 (2nd ICSSH 2018)

View full text Add to dashboard Cite

show abstract

“…It was reported that loss of TNF-α in acutely injured muscle represses p38 i.e., mitogen-activated protein kinase signals, at 3 days post injury, at muscle stem cells (MSCs) transition from the proliferation to differentiation phases of myogenesis. Moreover, TNF-α was found to activate NF-kB that is important for the function and homeostasis of satellite cells (34) . Hassan et al reported that the absence of local inflammatory cells with negative IHC expression of TNF-α and NF-κB, were related to negative Myo-D expression in regenerated mature MFs, while MNCs were positive for Myo-D, in the TQ injected groups (14) .…”

Section: Groupsmentioning

confidence: 99%

Effect of Thymoquinone on Skeletal Muscle Regeneration and Innervation in Induced Degeneration of the Hamster Buccal Pouch

Fahmy,

Korraah,

Attia

et al. 2023

Dental Science Updates

View full text Add to dashboard Cite

Introduction: Thymoquinone (TQ) has myogenic and neurogenic properties. Aim: This research aimed to study the effect of TQ on skeletal muscle regeneration and innervation in DMBA -induced degeneration of hamster buccal pouch (HBP). Material and Methods: 70 male golden Syrian hamsters were divided into 3 groups. Group A: (5) untreated animals. Group B: (5 animals), their left pouches were painted with 0.5% DMBA 3/week/6 weeks. Group C: (60 animals) was treated as group B, then divided equally into Group CI and Group CII: They received one and two i.p. TQ (0.1 mg/kg body weight) injection(s), respectively, then 5 animals from each subgroup were euthanized at 1, 2, 4, 7, 14, and 20 days. All pouches were surgically excised and processed for H&E, and immunohistochemistry stain of Pax-7 and neurofilament heavy chain (NFH). The obtained data were statistically analyzed. Results: The muscle layer' bulk of left pouches was progressively forming from 7 and 4 days after one and two TQ injection(s), respectively. Perivascular mononuclear cells (MNCs) were Pax-7 positive from the second and first day(s) to 14 and 7 days after one and two injection(s), as well the nuclei of mature muscle fibers (MFs) from 4 and 2 days to about 20 and 14 days after one and two TQ injection(s), respectively. The intensity of NFH IHC stain was progressively increased from the second and first day(s) after one and two TQ injection(s), respectively, as MFs membranes' plaques. Conclusion: TQ stimulated skeletal muscles' regeneration and re-innervation in HBPs.

show abstract

Tumor Necrosis Factor Alpha (TNF-α), Nuclear Factor of kappa B (NF-kB) p65 and Calcineurin Expression play a role in the regulation of muscle regeneration process through aerobic exercise in HIV patients

Cited by 2 publications

References 0 publications

High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) Against TNF-α and IL-6 levels In Rats

High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) Against TNF-α and IL-6 levels In Rats

Effect of Thymoquinone on Skeletal Muscle Regeneration and Innervation in Induced Degeneration of the Hamster Buccal Pouch

Contact Info

Product

Resources

About