Tumor necrosis factor alpha promoter‐308G/A polymorphism in Mexican patients with patchy alopecia areata

Cristina, Cantú-Salinas; Mauricio, Salinas-Santander; Armando, Lagos-Rodríguez; Celia, Sánchez-Domínguez; Clara, Rios-Ibarra; Ortı́z-López, Rocio; Welsh, Oliverio; Ocampo‐Candiani, Jorge

doi:10.1111/j.1365-4632.2011.05291.x

Cited by 12 publications

(15 citation statements)

References 35 publications

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“…In this study, an association between rs1800629 of the TNFα-308G/A and AA was confirmed ( P = 0.022) and found to be consistent with the results of Gregoriou et al13 It is also consistent with another study performed by Cristina et al in Mexico which suggested a credible association between the presence of TNFa-308G/A polymorphism and an increased susceptibility for the development of patchy AA 23. This overproduction of T NFα might lead to a higher risk of facilitating an autoimmune response against the hair follicle.…”

Section: Discussionsupporting

confidence: 92%

<p>Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study</p>

AL-Eitan¹,

Momani²,

Momani³

et al. 2019

TACG

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BackgroundAlopecia areata (AA) is a non-cicatricial patchy hair loss on the scalp, face or other parts of the body. AA was found to be responsive to immunosuppressive therapies, a finding that supports an autoimmune basis for the disease. Several genetic studies have shown the significance of immunological factors as key genetic components in AA.ObjectiveIn this study, we aimed to investigate the genetic association of 7 single-nucleotide polymorphisms (SNPs) within five candidate genes including TAP1, CXCL1, CXCL2, HSPA1B, and TNFα with AA susceptibility in the Jordanian Arab population.MethodsA case–control genetic association study conducted in 152 patients and 150 healthy individuals was performed using the sequenom MassARRAY system (iPLEX GOLD) to genotype the selected SNPs.Resultsrs1800629 SNP of the TNFα gene was significantly associated with AA in the heterozygous and rare homozygous genotypes (P=0.022 and P=0.0079, respectively) with no linkage of the TAP1, CXCL1, CXCL2 and HSPA1B variants.ConclusionThis is the first study of its kind among the Jordanian population providing evidence of genetic association of the TNFα with AA susceptibility. Further genetic studies on Arab descent including other variants are required to clarify and strengthen the association of these genes with susceptibility to develop AA.

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Section: Discussionsupporting

confidence: 92%

<p>Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study</p>

AL-Eitan¹,

Momani²,

Momani³

et al. 2019

TACG

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“…The frequency of allele –308A was not higher than 10% in Mestizos. This polymorphism seems to be very similarly distributed among Mexicans , and in general, for some Latin‐American populations, such as Colombians, Venezuelans, and Argentineans , with only two exceptional Mexican cases, in which allele A accounted for 20% of the frequency in individuals from the state of Nuevo Leon and Mexico City . Moreover, in European and African populations, the frequency of this allele ranges from 5% to 23% ; in particular, in the Spanish and the Portuguese, these values reach 15% and 24%, respectively.…”

Section: Discussionmentioning

confidence: 90%

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

et al. 2014

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The so-called tumor necrosis factor (TNF) block includes the TNFA, lymphotoxin alpha and beta (LTA and LTB) genes with single-nucleotide polymorphisms (SNP) and microsatellites with an allele frequency that exhibits interpopulation variability. To date, no reports have included both SNPs and microsatellites at the TNF block to study Mestizo or Amerindian populations from Mexico. In this study, samples of five Mexican Mestizo populations (Durango, Guadalajara, Monterrey, Puebla, and Tierra Blanca) and four native-Mexican populations (North Lacandonians, South Lacandonians, Tepehuanos, and Yaquis) were genotyped for two SNPs (LTA+252A>G and TNFA-308G>A) and four microsatellites (TNFa, d, e, and f), to analyze the genetic substructure of the Mexican population. Allele and haplotype frequencies, linkage disequilibrium (LD), and interpopulation genetic relationships were calculated. There was significant LD along almost all of the TNF block but the lowest D' values were observed for the TNFf-TNFd pair. Mestizos showed higher allele and haplotype diversity than did natives. The genetic differentiation level was reduced among Mestizos; however, a slightly, but significant genetic substructure was observed between northern and southern Mexican Mestizos. Among the Amerindian populations, the genetic differentiation level was significantly elevated, particularly in both North and South Lacandonians. Furthermore, among Southern Lacandonians, inhabitants of Lacanja town were the most differentiated from all the Mexicans analyzed. The data presented here will serve as a reference for further population and epidemiological studies including these TNF polymorphisms in the Mexican population.

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“…19 In one study, a tumour necrosis factor-a gene polymorphism (-308 G/A) confered increased susceptibility for the development of patchy alopecia areata. 20 The present study investigated polymorphisms in the genes for the cytokines IL-12, IL-17 and IL-23. To the best of our knowledge, this is the first study to investigate IL12 and IL23R gene SNPs in alopecia areata.…”

Section: Discussionmentioning

confidence: 99%

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

Aytekin¹,

Akçalı

Pehlıvan

et al. 2015

J Int Med Res

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Objective: To investigate the distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G) and IL-23 receptor (IL23R; þ2199A/C) gene polymorphisms in patients with alopecia areata. Methods: Patients with alopecia areata and healthy controls were enrolled in this case-control study. Genotyping of the IL12 (1188A/C), IL17 (A7488G) and IL23R (þ2199A/C) polymorphisms was undertaken. Genotype frequencies were compared between the two groups. Results: The study enrolled 100 patients with alopecia areata and 71 control subjects. No significant differences were found in the frequencies for the IL12 and IL23R gene polymorphisms between the patient and control groups. The IL17 GG genotype was significantly more common and the IL17 GA genotype was significantly less common in patients with alopecia areata compared with controls, but only 10% of patients had the GG genotype. Conclusion: The IL17 GG genotype was associated with susceptibility for alopecia areata, but this genotype was only present in a small number of patients. The IL12 and IL23R gene polymorphisms were not found to have a significant association with alopecia areata.

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Tumor necrosis factor alpha promoter‐308G/A polymorphism in Mexican patients with patchy alopecia areata

Abstract: Our data suggest that there is a plausible association between the presence of the TNFα-308G/A polymorphism and a higher susceptibility for developing patchy AA. This risk might be due to overproduction of TNFα, which would facilitate an autoimmune response against the hair follicle.

Cited by 12 publications

References 35 publications

<p>Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study</p>

<p>Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study</p>

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

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