&lt;p&gt;Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study&lt;/p&gt;

AL-Eitan, Laith N.; Momani, Rawan O. Al; Momani, Khalid K Al; Warawrah, Ahmad M Al; Aljamal, Hanan A.; Alghamdi, Mansour A.; Muhanna, Alsharif M.; Al‐Qarqaz, Firas

doi:10.2147/tacg.s226664

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Blood samples were collected in ethylenediaminetetraacetic acid (EDTA) for genomic DNA (gDNA) extraction using Wizard® Genomic DNA Purification Kit (Qiagen, Germany) provided upon a research collaboration with Al-Eitan et al. (2019) .…”

Section: Methodsmentioning

confidence: 99%

“…The underlying genetic association with AA susceptibility in patients of Arab descent remains unsettled since there is only limited studies according to the Centre of Arab Genomic Studies (CAGS) ( CAGS database ), as well as in Jordan ( Al-Refu, 2013 ; Helalat and Ma'ayta, 2013 ; Al-Eitan et al., 2019 ). To the best of our knowledge, this study is the first of its kind on the genetic involvement of MASP2, TLR1, CTLA4, and C11orf30 polymorphisms with AA in the Jordanian population.…”

Section: Introductionmentioning

confidence: 99%

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Genetic predisposition of alopecia areata in jordanians: A case-control study

AL-Eitan

Alghamdi

Momani

et al. 2022

Heliyon

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic predisposition of alopecia areata in jordanians: A case-control study

AL-Eitan

Alghamdi

Momani

et al. 2022

Heliyon

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“…Assessment of the patients was conducted according to the standard evaluation guidelines for AA identification. 19 This study adopted the general characteristics for controls summarized and categorized in 2017 by AL-Eitan et al 20 …”

Section: Methodsmentioning

confidence: 99%

“…Ten SNPs within the five candidate IL genes were selected based on their known implications in AA studies or association with other autoimmune diseases. Genomic DNA was isolated using Wizard® Genomic DNA Puriﬁcation Kit (Qiagen, Germany) was provided by Al-Eitan et al, 20 upon a research collaboration. DNA samples were genotyped in duplicate with a success rate of ≥ 95% using the Sequenom MassARRAY® system (iPLEX GOLD) (Sequenom, San Diego, CA, USA), in collaboration with the Australian Genome Research Facility.…”

Section: Methodsmentioning

confidence: 99%

Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

AL-Eitan¹,

Alghamdi²,

Momani³

et al. 2022

Oman Med J

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Objectives Alopecia areata (AA) is a multifactorial autoimmune disease with a strong genetic predisposition. A variety of genes involved in immunity and inflammatory responses, such as cytokines, are suspected to increase the risk of developing AA. In which, different interleukin (IL) genes that associated with several autoimmune diseases and AA in varied populations. The objective of this study was to investigate the possible genetic association of AA with ten variants of single nucleotide polymorphism (SNP) in IL12B,IL13,IL16,IL17A, and IL18 genes among Jordanian patients. Methods In this case-control study, peripheral blood samples of 152 Jordanian AA patients and 150 controls (total of 302 subjects) were collected, genomic DNA extracted and genotyped, based on which their allele and genotype frequencies were assessed. Results In the rs11073001 SNP located in the exon region of the IL16 gene, the A allele was distributed more frequently in AA patients ( p = 0.01). A difference was found between the patients and the controls for the rs17875491 SNP in the promoter region of the IL16 gene ( p = 0.04). The mean age of onset was 27.3±12.6 with male predominance. Most patients (68.4%) were asymptomatic but some reported experiencing associated sensations before the hair loss episodes. The patchy patterns of alopecia were the most common (90.3%). Nail changes were found in 7.3% of the patients. Conclusions The findings support the hypothesis of the involvement of IL16 gene in the etiology of AA. Moreover, it emphasizes the variations in the genetic component of AA, as well as the clinical phenotypes among different ethnic groups.

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“…Skin biopsies of affected lesions showed lymphocytic infiltration around the hair bulb [ 3 ]. Genome-wide association studies in animal models and patients depicted AA as a complex polygenic disorder with several genetically susceptible loci enclosing high-risk candidate genes [ 1 , 4 , 5 ]. Alopecia areata is challenging to manage medically; therefore, a new targeted therapy is warranted to overcome the hurdles encountered during management.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case–Control Study

Faisal

Toraih

Atef

et al. 2022

Genes

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Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for the first time, the miR-17-92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. We also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) and the available clinical data. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated for each genetic association model. The upregulation of miR-17 was observed in the serum of patients with alopecia compared to controls (p-value = 0.004). The ROC curve showed high diagnostic performance of miR-17 in differentiating between patients and controls (AUC = 0.85, p-value < 0.001). rs4284505*A/G heterozygotes were more susceptible to the disease (OR = 1.57, 95% CI = 1.01–2.45) under the over-dominant model. Interestingly, patients with the rs4284505*G/G genotype had a higher level of miR-17 than those with the A/A and A/G genotypes. The G/G genotype was associated with the severe phenotype (p-value = 0.038). A/G carriers were the youngest (p-value < 0.001), had more frequent scalp infection (p-value = 0.006), exhibited the worst dermatology life quality index score (p-value = 0.037), and responded less to treatment (p-value = 0.033). In conclusion, MIR17HG expression and the rs4284505 variant were significantly associated with AA and could play a role in pathogenesis and phenotype in the Egyptian population. Further multi-center studies in other ethnicities are warranted to replicate the findings.

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<p>Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case–Control Study</p>

Cited by 6 publications

References 24 publications

Genetic predisposition of alopecia areata in jordanians: A case-control study

Genetic predisposition of alopecia areata in jordanians: A case-control study

Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case–Control Study

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