Tumor necrosis factor alpha is a potent regulator in fish adipose tissue

Liu, Dongwu; Mai, Kangsen; Ai, Qinghui

doi:10.1016/j.aquaculture.2014.10.030

Cited by 11 publications

(5 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is one of the most important cytokines secreted from adipose tissue and plays a significant role in the regulation of lipid metabolism. Many studies have indicated TNF-α accelerates steatolysis in vitro through the activation of ERK1/2, p38 kinase, and JNK (Liu et al 2015;Ryden et al 2002). In the present study, tissue TNF-α expression of Megalobrama amblycephala increased with increasing dietary GA levels.…”

Section: Discussionsupporting

confidence: 58%

“…TNF-α is known as a restrictive factor in lipid deposition of fish and promotes lipolysis (Liu et al 2015). It is one of the most important cytokines secreted from adipose tissue and plays a significant role in the regulation of lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…GA has traditionally been used as an anti-inflammatory in Chinese medicine through the mediating of tumor necrosis factor alpha (TNF-α) and NF-κB (Ishida et al 2012). TNF-α is one of the most important cytokines secreted from adipose and liver tissue, which plays a significant role in the regulation of lipid metabolism, especially in fish (Liu et al 2015). According to previous studies, TNF-α is a limiting factor of lipid depositional in gilthead sea bream (Saera-Vila et al 2007).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

My¹,

Gx²,

Zhou³

et al. 2018

Israeli Journal of Aquaculture - Bamidgeh

View full text Add to dashboard Cite

As from January 2010 The Israeli Journal of Aquaculture-Bamidgeh (IJA) has been published exclusively as an online Open Access scientific journal, accessible by all. Please visit our IJA Website http://www.aquaculturehub.org/group/israelijournalofaquaculturebamidgehija for free publications and to enable you to submit your manuscripts. This transformation from a subscription printed version to an online Open Access journal aims at supporting the concept that scientific peer-reviewed publications and thus the IJA publications should be made available to all for free.

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

My¹,

Gx²,

Zhou³

et al. 2018

Israeli Journal of Aquaculture - Bamidgeh

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that Hsl presents in fish and performs a similar lipolytic function to that of mammals (38,39,40) . In addition, the fish with excessive fat deposition are often accompanied by abnormal hsl expression (41,42,43,44) .…”

Section: Introductionmentioning

confidence: 92%

“…Hence, how to promote the ability of fish to mobilise fat has been a hot area for fish physiologists. Previous studies have shown that Hsl presents in fish and performs a similar lipolytic function to that of mammals (38)(39)(40) . In addition, the fish with excessive fat deposition are often accompanied by abnormal hsl expression (41)(42)(43)(44) .…”

mentioning

confidence: 92%

The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism in fish

et al. 2022

View full text Add to dashboard Cite

Hormone-sensitive lipase is one of the rate-determining enzymes in the hydrolysis of triglyceride, playing a crucial role in lipid metabolism. However, the role of HSL-mediated lipolysis in systemic nutrient homeostasis has not been intensively understood. Therefore, we used CRISPR/Cas9 technique and Hsl inhibitor (HSL-IN-1) to establish hsla-deficient (hsla-/-) and Hsl-inhibited zebrafish models, respectively. As a result, the hsla-/- zebrafish showed retarded growth and reduced oxygen consumption rate, accompanied with higher mRNA expression of the genes related to inflammation and apoptosis in liver and muscle. Furthermore, hsla-/- and HSL-IN-1 treated zebrafish both exhibited severe fat deposition, whereas their expressions of the genes related to lipolysis and fatty acid oxidation were markedly reduced. The thin layer chromatography results also showed that the dysfunction of Hsl changed the whole body lipid profile, including increasing the content of TG and decreasing the proportion of PL. In addition, the systemic metabolic pattern was remodeled in hsla-/- and HSL-IN-1 treated zebrafish. The dysfunction of Hsl lowered the glycogen content in liver and muscle, enhanced the utilization of glucose plus the expressions of glucose transporter and glycolysis genes. Besides, the whole-body protein content had significantly decreased in the hsla-/- and HSL-IN-1 treated zebrafish, accompanied with the lower activation of the mTOR pathway and enhanced protein and amino acid catabolism. Taken together, Hsl plays an essential role in energy homeostasis, and its dysfunction would cause the disturbance of lipid catabolism but enhanced breakdown of glycogen and protein for energy compensation.

show abstract

Innate Immunity

Dalmo

Bøgwald

2022

Principles of Fish Immunology

View full text Add to dashboard Cite

Research on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing danger molecules from pathogens. This has been facilitated through genome and transcriptome sequencing of different fish species. Also, endogenous host molecules from sterile physiological insults may also bind to certain receptors and induce immunological processes. The magnitude and quality of adaptive immunity are known to be dependent on the instructions the innate response gives. This chapter gives an overview of selected innate immune organs/tissues, factors, and processes that have been suggested to possess important roles during innate immune response in fish.

show abstract

Tumor necrosis factor alpha is a potent regulator in fish adipose tissue

Cited by 11 publications

References 119 publications

Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

The dysfunction of hormone-sensitive lipase induces lipid deposition and reprogramming of nutrient metabolism in fish

Innate Immunity

Contact Info

Product

Resources

About