Abstract:Hormone-sensitive lipase is one of the rate-determining enzymes in the hydrolysis of triglyceride, playing a crucial role in lipid metabolism. However, the role of HSL-mediated lipolysis in systemic nutrient homeostasis has not been intensively understood. Therefore, we used CRISPR/Cas9 technique and Hsl inhibitor (HSL-IN-1) to establish hsla-deficient (hsla-/-) and Hsl-inhibited zebrafish models, respectively. As a result, the hsla-/- zebrafish showed retarded growth and reduced oxygen consumption rate, accom… Show more
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