2007
DOI: 10.1111/j.1600-0897.2006.00455.x
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Tumor Necrosis Factor‐alpha in Gestation and Puerperium of Women with Gestational Hypertension and Pre‐eclampsia

Abstract: In vivo monocyte activation in GH and PE pregnant women was characterized by in vitro TNF-alpha production. The fact that higher circulating concentrations of TNF-alpha and uric acid were observed in PE than in GH suggests an association with disease severity.

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Cited by 90 publications
(69 citation statements)
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“…[24][25][26] Regarding hypertensive disorders of pregnancy, preeclampsia has been linked to increased serum levels of proinflammatory cytokines, such as IL-6, IL-8, and TNF-α, accompanied by an angiogenic factor imbalance, and for gestational hypertension, increased serum IL-1β, IL-10, and TNF-α has been reported. [27][28][29][30][31][32] Information is limited for early pregnancy; serum IL-1β and TNF-α has been shown elevated before onset of disease in women developing preeclampsia, whereas gestational hypertension has not been separately investigated at early gestation. 33,34 This study aimed to compare disease-specific early gestation serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia.…”
Section: Tangerås Et Al Cytokines In Hypertensive Pregnancy Disordersmentioning
confidence: 99%
“…[24][25][26] Regarding hypertensive disorders of pregnancy, preeclampsia has been linked to increased serum levels of proinflammatory cytokines, such as IL-6, IL-8, and TNF-α, accompanied by an angiogenic factor imbalance, and for gestational hypertension, increased serum IL-1β, IL-10, and TNF-α has been reported. [27][28][29][30][31][32] Information is limited for early pregnancy; serum IL-1β and TNF-α has been shown elevated before onset of disease in women developing preeclampsia, whereas gestational hypertension has not been separately investigated at early gestation. 33,34 This study aimed to compare disease-specific early gestation serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia.…”
Section: Tangerås Et Al Cytokines In Hypertensive Pregnancy Disordersmentioning
confidence: 99%
“…This cytokine is a potent and multifunctional proinflammatory Th 1 type cytokine that is involved in the pathogenesis of a large number of autoimmune and inflammatory diseases. Its role has previously been associated with pregnancy pathologies such as PE [12], intrauterine growth restriction [13], gestational diabetes mellitus [14], spontaneous preterm delivery [15] and recurrent abortions [16]. …”
Section: Introductionmentioning
confidence: 99%
“…6,7 A number of variables, such as maternal body mass index (BMI) and age are controversially discussed to influence maternal TNF-α levels during pregnancy, whereas increased TNF-α is associated with a number of adverse pregnancy conditions including gestational hypertension and gestational diabetes mellitus (GDM). 7,8 Elevated TNF-α levels during distressed pregnancies have been suggested to affect trophoblast biology including migratory activity, syncytialization, and endocrine function. 9,10 Moreover, elevated TNF-α may influence the fetal-maternal cross-talk by provoking a shift in the secretory profile of placenta-derived immunemodulating factors, which in turn influences the activity of maternal immune cells.…”
mentioning
confidence: 99%