Tumor Necrosis Factor Alpha −308 G/A Single-Nucleotide Polymorphism and Apical Periodontitis: An Updated Systematic Review and Meta-analysis

Jakovljević, Aleksandar; Nikolic, Nadja; Jaćimović, Jelena; Miletić, Maja; Andrić, Miroslav; Milašin, Jelena; Aminoshariae, Anita; Azarpazhooh, Amir

doi:10.1016/j.joen.2021.03.007

Cited by 12 publications

(25 citation statements)

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“…After reviewing the title and abstracts, 349 were removed, and the full texts for five systematic reviews with or without meta-analyses were retrieved and finally assessed for eligibility. After the full-text evaluation, all five identified systematic reviews that addressed the research question (Aminoshariae & Kulild, 2015;Jakovljevic, Nikolic, et al, 2021;Salles et al, 2017Salles et al, , 2018Torres et al, 2020) were included in the current umbrella review. The complementary searches of the PROSPERO register and JBI Evidence Synthesis Reports did not reveal any ongoing/ finalized systematic reviews.…”

Section: Literature Search Processmentioning

confidence: 99%

“…Three reviews used PubMed, Scopus, Web of Science or Virtual Health Library (Salles et al, 2017(Salles et al, , 2018Torres et al, 2020) as databases to identify relevant studies, and they originate from the same scientific group. One study (Jakovljevic, Nikolic, et al, 2021) used a very broad collection of databases, namely Clarivate Analytics Web of Science, Scopus, PubMed, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, and one study (Aminoshariae & Kulild, 2015) searched MEDLINE, Embase, Cochrane and PubMed. The search period within the reviews ranged from inception to 2020.…”

Section: Characteristics Of Included Reviewsmentioning

confidence: 99%

“…Three reviews (Aminoshariae & Kulild, 2015;Salles et al, 2017Salles et al, , 2018) used a 10-point modified proposed specific quality assessment scale for genetic association studies for the quality assessment of the included studies. The remaining two studies used the STrengthening the REporting of Genetic Association studies (STREGA) checklist (Jakovljevic, Nikolic, et al, 2021;Torres et al, 2020) whilst one of them combined it with the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) recommendations and a modified, specific quality assessment scales for genetic associations (Jakovljevic, Nikolic, et al, 2021).…”

Section: Characteristics Of Included Reviewsmentioning

confidence: 99%

“…SNPs, as the most common DNA sequence variations, are the types of genetic factors that can contribute greatly to the aetiology of complex diseases (Coetzee, 2019). So far, the results of previous primary clinical studies are rather inconclusive, and several systematic reviews and meta-analyses have tried to assess the association by qualitative and/or quantitative data synthesis (Aminoshariae & Kulild, 2015;Jakovljevic, Nikolic, et al, 2021;Salles et al, 2017Salles et al, , 2018Torres et al, 2020). Although some systematic reviews suggested potential association between investigated genes and development of AP, the results remain elusive and inconclusive (Aminoshariae & Kulild, 2015;Jakovljevic, Nikolic, et al, 2021;Salles et al, 2017Salles et al, , 2018Torres et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review

et al. 2022

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Background:The interaction between heredity and different environmental factors in the modification of apical periodontitis (AP) susceptibility and prediction of its progression remain poorly elucidated.Objectives: This umbrella review aimed to (i) analyse the available relevant systematic reviews in an attempt to determine the association between genotype and allelic distribution of different single-nucleotide polymorphisms (SNPs) and the development of AP, (ii) report deficiencies and gaps in knowledge in this area and (iii) present recommendations to conduct future clinical studies and systematic reviews.Methods: A literature search was conducted using Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to October 2021, with no language restrictions, including a grey literature search. Systematic reviews with/without meta-analysis evaluating genotype and allelic distribution of different SNPs between adult patients with/ without AP were included. All other type of studies were excluded. The methodological quality was assessed using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR)-2 tool. Two independent reviewers were involved in study selection, data extraction and appraising the included reviews; disagreements were resolved by a third reviewer. Results:The current study includes five systematic reviews. Three reviews performed meta-analysis. Three reviews were graded by AMSTAR 2 as 'critically low' quality, whereas the other two were graded as 'low' and 'moderate' quality. Two reviews indicated that carriers of specific genotypes and alleles of tumour necrosis factor-alpha (TNF-α) -308 G > A and interleukin 1-beta (IL-1β) + 3954 C/T gene polymorphisms are more susceptible to an acute and persistent form of AP. However, high heterogeneity was observed. Discussion:The statistical heterogeneity within included systematic reviews was a consequence of clinical and methodological diversity amongst primary studies.Although some of the included reviews suggested that carriers of specific genotype Funding: No funding

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Section: Literature Search Processmentioning

confidence: 99%

Section: Characteristics Of Included Reviewsmentioning

confidence: 99%

Section: Characteristics Of Included Reviewsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review

et al. 2022

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“…Since Gram negative anaerobic bacteria can induce the loss of attachment observed in periodontitis, candidate genes have been initially selected among those codifying for inflammatory mediators extending thereafter to various others, involved in infection susceptibility and association with chronic diseases, with conflictual results. 13 , 14 , 15 , 16 , 17 , 18 Several aspects of the relationship between oral indicators and bone mineral density have also been investigated. 19 , 20 As the rate of local bone loss and structural factors of periodontal tissues may influence also the rate of tooth loss, the hypothesis that polymorphisms in genes of the host bone metabolism could be associated with the number of remaining teeth and with incident tooth loss relies on a robust rationale.…”

Section: Introductionmentioning

confidence: 99%

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

Musacchio

Binotto

Silva-Netto

et al. 2022

Journal of Dental Sciences

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Background/purpose Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth. Materials and methods Participants in the Pro.V.A. longitudinal Study: 3099 Italians (aged 65+ at baseline), 2196 at follow-up 1 (5yrs), 1641 at follow-up 2 (7yrs) underwent detailed interview and clinical-instrumental examination. Subjects, grouped by remaining teeth number (0, 1–7, 8–19, 20+), were genotyped for six different bone-related polymorphisms: collagen type Iα1 (COL1A1, Sp1, Ss alleles, n = 1068), vitamin D receptor (VDR, Fok I, Ff alleles, n = 300), calcitonin receptor (CALCR, Alu I, CT alleles, n = 1430), estrogen receptor alpha (ESR1, Pvu II and Xba I, Pp and Xx alleles, n = 1335 and n = 1324). Results COL1A1 associated with dental status: ss carriers had reduced incident tooth loss (p < 0.05). The low frequency of this genotype, 3.6% in the whole population, didn't grant sufficient statistical power to other findings, such as the lower prevalence of edentulism, consistent throughout the study. In men, CC genotype of CALCR was associated with higher tooth loss between follow ups (p < 0.05). Biochemical markers of inflammation didn't differ by genotype. Confounders such as diabetes, neoplasms, and smoking hampered the detrimental effect of S allele in the logistic regression analysis (OR = 0.67, 95% CI 0.4–1.0, p = 0.06). Conclusion The present study, demonstrating an association between tooth loss and COL1A1 and -in men- CALCR, contributes to the identification of genes involved in tooth loss and, possibly, susceptibility to periodontitis.

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Understanding the potential immunogenetic role of TNFα-308 polymorphism in the pathogenesis of recurrent miscarriage

Ali¹,

Majid²,

Ali³

et al. 2023

Heliyon

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Tumor Necrosis Factor Alpha −308 G/A Single-Nucleotide Polymorphism and Apical Periodontitis: An Updated Systematic Review and Meta-analysis

Cited by 12 publications

References 34 publications

Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review

Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis—An umbrella review

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

Understanding the potential immunogenetic role of TNFα-308 polymorphism in the pathogenesis of recurrent miscarriage

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