Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

Abstract

Background/purpose Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth. Materials and methods Participants in the Pro.V.A. longitudinal Study: 3099 Italians (aged 65+ at baseline), 2196 at follow-up 1 (5yrs), 1641 at follow-up 2 (7yrs) underwent detailed interview and clinical-instrumental examination. Subjects, grouped by remaining teeth number (0, 1–7, 8–19, 20+), were genotyped for six different bone-related polymorphisms: collagen type Iα1 (COL1A1, Sp1, Ss alleles, n = 1068), vitamin D receptor (VDR, Fok I, Ff alleles, n = 300), calcitonin receptor (CALCR, Alu I, CT alleles, n = 1430), estrogen receptor alpha (ESR1, Pvu II and Xba I, Pp and Xx alleles, n = 1335 and n = 1324). Results COL1A1 associated with dental status: ss carriers had reduced incident tooth loss (p < 0.05). The low frequency of this genotype, 3.6% in the whole population, didn't grant sufficient statistical power to other findings, such as the lower prevalence of edentulism, consistent throughout the study. In men, CC genotype of CALCR was associated with higher tooth loss between follow ups (p < 0.05). Biochemical markers of inflammation didn't differ by genotype. Confounders such as diabetes, neoplasms, and smoking hampered the detrimental effect of S allele in the logistic regression analysis (OR = 0.67, 95% CI 0.4–1.0, p = 0.06). Conclusion The present study, demonstrating an association between tooth loss and COL1A1 and -in men- CALCR, contributes to the identification of genes involved in tooth loss and, possibly, susceptibility to periodontitis.

Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016

“…Furthermore, little is known about the impact of genetic polymorphism on tooth loss; although, genetic risk seems to contribute to increased odds of losing more teeth according to previous studies. 22,23 Thus, the aims of the present study were to investigate the association between periodontitis and SNPs in the sequence of four genes involved in DNA methylation (rs2288349 in DNMT1, rs35474715 in IDH2, rs34023346 in TET1, and rs10010325 in TET2), as well as between the same SNPs and tooth loss, hs-CRP, and HbA1c levels.…”