Tumor Necrosis Factor-a and Iron Overload Are Associated with Insulin Resistance in Hepatitis C in Egyptian Patients

Hassan, Waleed N; Mohamed, Mohsen S.; Ahmed, EL-Shinnawy H; Abd-El-Mageed, Gameel K; Morsy, Mohamed D

doi:10.5099/aj100400342

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…Other mechanisms involving Tumour Necrosis Factor-a (TNF-a), development of hepatic steatosis and iron overload causing insulin resistance, lack of phosphatidylinositol (PI)-3 kinase activation have also been reported [20][21][22]. However, our study did not look into the aspect of pathogenesis causing IGT/ DM in our patients.…”

Section: Discussioncontrasting

confidence: 42%

To Study the Prevalence of Impaired Glucose Tolerance in Patients with Hepatitis C Virus Related Chronic Liver Disease

Kaur

Singh

Pannu

et al. 2015

JCDR

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Section: Discussioncontrasting

confidence: 42%

To Study the Prevalence of Impaired Glucose Tolerance in Patients with Hepatitis C Virus Related Chronic Liver Disease

Kaur

Singh

Pannu

et al. 2015

JCDR

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“…However, the change in copper status is directly connected with the change in TAS and TNF alpha level. Other studies support the hypothesis of elevated iron stores, as well as inflammation and oxidative stress, in the development of insulin status disorders [6, 34, 35]. The changes in both iron and copper following the l -arginine supplementation observed in this study may be associated with metabolic relationships between these elements [36, 37].…”

Section: Discussionsupporting

confidence: 84%

The Effects of l-Arginine, Alone and Combined with Vitamin C, on Mineral Status in Relation to its Antidiabetic, Anti-Inflammatory, and Antioxidant Properties in Male Rats on a High-Fat Diet

Suliburska

Bogdański

Krejpcio

et al. 2013

Biol Trace Elem Res

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The aim of this study was to evaluate the influence of the intake of l-arginine alone and of l-arginine with vitamin C on mineral concentration in rats fed with a high-fat diet, and to assess the lipid glucose, insulin, and total antioxidant status (TAS) and tumor necrosis factor (TNF) alpha serum levels that result. Wistar rats were assigned to groups fed with either a standard control diet (C), a diet high in fat (FD), a diet high in fat with l-arginine, or a diet high in fat with l-arginine and vitamin C. After 6 weeks, the length and weight of the rats were measured, and the animals were euthanized. The liver, spleen, kidneys, pancreas, heart, and gonads were collected, as were blood samples. The total serum cholesterol, triglyceride, fasting glucose, insulin, TAS, and TNF alpha levels were measured. The tissue calcium, magnesium, iron, zinc, and copper concentrations were determined. It was found that l-arginine supplementation diminished the effect of the modified diet on the concentration of iron in the liver and spleen and of copper in heart. At the same time, it was observed that l-arginine supplementation reduced the effect of the high-fat diet on insulin, TNF alpha, and TAS. The combination of l-arginine and vitamin C produced a similar effect on the mineral levels in the tissues as did l-arginine used alone. Moreover, positive correlations between serum insulin and iron in the liver, between TNF alpha and iron in the liver, and between TNF alpha and copper in the heart were observed. The level of TAS in serum was inversely correlated with the copper level in the heart and the iron level in the liver. We concluded that the beneficial influence of l-arginine on insulin, TAS, and TNF alpha serum level is associated with changes in the iron and copper status in rats fed with a high-fat diet. No synergistic effect of l-arginine and vitamin C in the biochemical parameters or in the mineral status in rats fed with the modified diet was observed.

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“…In those who presented with neurological symptoms, almost half experience a paradoxical worsening in their symptoms. While this phenomenon is also observed in other treatments for Wilson's, it is usually taken as an indication for discontinuing penicillamine and commencing second-line treatment (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Intolerant to penicillamine may instead be commenced on trientine hydrochloride, which also has chelating properties.…”

Section: Discussionmentioning

confidence: 99%

“…Wilson's disease (WD) is a disease in which the analysis of copper metabolism is impaired (1,2). On the other hand, the disease is an autosomal recessive disorder of copper metabolism which causes to copper accumulation in various organs and tissues that can be seen as clinical features.…”

Section: Introductionmentioning

confidence: 99%

Nano-scaled Diethylene Triamine Pent Acetic Acid (N-DTPA): Novel Anti-Wilson's Disease Cell Model

Zakeri¹,

Afzal²,

Yaghmaei³

et al. 2012

Am. J. Biomed. Sci.

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Wilson's disease (WD) is an autosomal recessive disorder in which copper metabolism is impaired. In fact, copper accumulates in various organs and tissues can be seen and causes toxic effects in various tissues including liver, brain, kidneys and eyes. Sulfur amino acid is a metabolite of D-penicillamine and penicillamine and copper Chlator is a factor that causes urinary excretion of copper and WD therapeutic agent as well. The interesting thing about the neurological symptoms of Wilson's disease with penicillamine is the drug may worsen or even in an asymptomatic patient, the treatment may be creating symptoms. DTPA is a pentavalent compound containing carboxylic DTPA is a chemical compound that is used in radiation therapy and MRI. It can give the metal chelate with iron, copper and other cations can be conjugated and also treatment of internal body pollution caused by various elements, including raDOIactive elements. DTPA could not be lonely absorbed by the cell. The goal is to conjugate it with the G2 Dendrimer (Nanosized anionic linear biocompatible polymer) to bring it to the nano size and increase the intracellular uptake compared to the ground state. Based on the hypothesis, nanoconjugated DTPA-Dendrimer G2 was synthesized and then evaluated on Hep G2 WD cell model in vitro and the results showed a good effectiveness without any toxicity for the conjugate in decreasing the intracellular copper level comparing to gold standard D-penicillamine respectively. Based on the findings the nanosized conjugate seems to have very good prognoses and clinical future and this needs to be further investigated.

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Tumor Necrosis Factor-a and Iron Overload Are Associated with Insulin Resistance in Hepatitis C in Egyptian Patients

Cited by 4 publications

References 54 publications

To Study the Prevalence of Impaired Glucose Tolerance in Patients with Hepatitis C Virus Related Chronic Liver Disease

To Study the Prevalence of Impaired Glucose Tolerance in Patients with Hepatitis C Virus Related Chronic Liver Disease

The Effects of l-Arginine, Alone and Combined with Vitamin C, on Mineral Status in Relation to its Antidiabetic, Anti-Inflammatory, and Antioxidant Properties in Male Rats on a High-Fat Diet

Nano-scaled Diethylene Triamine Pent Acetic Acid (N-DTPA): Novel Anti-Wilson's Disease Cell Model

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