Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Chen, Qian; Shan, Xueru; Shi, Suqing; Jiang, Chunzhu; Li, Tinghua; Wei, Shanshan; Zhang, Xinyu; Sun, Guoying; Liu, Jianhua

doi:10.1039/d0tb00248h

Cited by 36 publications

(24 citation statements)

References 36 publications

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“…As shown in Table 1, 808 nm laser is the mainly photothermal conversion option. But there are exceptions that PDA also exhibited remarkable photothermal properties under 1064 nm and 665 nm laser, with photothermal conversion efficiencies of 41 % [54] and 60.4 %, [55] respectively. It might come from the differences in the thickness of the PDA layer and the concentration of nanoparticles.…”

Section: Pda Nps‐based Ptt For Tumor Treatmentmentioning

confidence: 99%

Polydopamine‐Based Nanoparticles for Photothermal Therapy/Chemotherapy and their Synergistic Therapy with Autophagy Inhibitor to Promote Antitumor Treatment

Lü

Cai

Dai

et al. 2021

The Chemical Record

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Polydopamine (PDA) has attracted much attention recently due to its strong adhesion capability to most substrates. After combining with organic (such as organic metal framework, micelles, hydrogel, polypeptide copolymer) or inorganic nanomaterials (such as gold, silicon, carbon), polydopamine‐based nanoparticles (PDA NPs) exhibit the merging of characteristics. Until now, the preparation methods, polymerization mechanism, and photothermal therapy (PTT) or chemotherapy (CT) applications of PDA NPs have been reported detailly. Since the PTT or CT treatment process is often accompanied by exogenous stimuli, tumor cells usually induce pro‐survival autophagy to protect the cells from further damage, which will weaken the therapeutic effect. Therefore, an in‐depth understanding of PDA NPs modulated PTT, CT, and autophagy is required. However, this association is rarely reviewed. Herein, we briefly described the relationship between PTT/CT, autophagy, and tumor treatment. Then, the outstanding performances of PDA NPs in PTT/CT and their combination with autophagy inhibitors for tumor synergistic therapy have been summarized. This work is expected to shed light on the multi‐strategy antitumor therapy applications of PDA NPs.

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Section: Pda Nps‐based Ptt For Tumor Treatmentmentioning

confidence: 99%

Polydopamine‐Based Nanoparticles for Photothermal Therapy/Chemotherapy and their Synergistic Therapy with Autophagy Inhibitor to Promote Antitumor Treatment

Lü

Cai

Dai

et al. 2021

The Chemical Record

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“…Fenton and Fenton-like reactions, which generate abundant oxidative •OH or O 2 , can be triggered by the endogenous H 2 O 2 of cancer cells and catalyzed by transition metal ions or their complexes [ 18 ]. While Fenton and Fenton-like reactions are commonly suppressed by the insufficient H 2 O 2 and slightly alkaline conditions of a normal microenvironment, in the acidic TME, metal ions can be dissolved from iron or other transition metal ions-based nanomaterials to activate Fenton and Fenton-like reactions [ 19 ]. On the one hand, the production of •OH can result in oxidant damage to cellular constituents (proteins, lipids, DNA, et al), apoptosis or necrosis, and likely cell death [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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“… 30 − 32 Besides, the structure of PDA is similar to the adhesive proteins of mussels, making it capable to adhere to the surface of various materials as a diverse surface functionalization method. 33 , 34 …”

Section: Introductionmentioning

confidence: 99%

Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor

et al. 2021

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The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection of osteosarcoma is still a challenge in the clinic. Combination therapy based on a localized drug-delivery system shows great promise in the treatment of osteosarcoma. Herein, bifunctional polydopamine (PDA)-modified curcumin (CM)-loaded silk fibroin (SF) composite (SF/CM-PDA) nanofibrous scaffolds, which combined photothermal therapy with chemotherapy to synergistically enhance osteosarcoma therapy, were prepared by PDA coating of the SF/CM nanofibrous scaffolds fabricated by supercritical carbon dioxide (SC-CO 2 ) technology. The PDA coating improved hydrophilicity and mechanical strength of the SF/CM scaffolds. The SF/CM-PDA scaffolds present good photothermal conversion capacity and excellent photostability. The low pH and near-infrared (NIR) irradiation could effectively accelerate release of CM in the SF/CM-PDA scaffolds. The in vitro anticancer results indicated that the biocompatible SF/CM-PDA scaffolds had a long-term, stable, and superior anticancer effect compared to pure CM. Furthermore, the SF/CM-PDA scaffolds significantly increased the growth inhibition of osteosarcoma MG-63 cells under NIR irradiation (808 nm and 1.3 W/cm 2 ). Besides, the SF/CM-PDA scaffolds could enhance osteoblast MC3T3-E1 cell proliferation in vitro when the mass ratio of CM was 0.05–0.5%. This work has therefore demonstrated that the bifunctional SF/CM-PDA scaffolds provide a competitive strategy for local osteosarcoma therapy and bone regeneration.

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Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Abstract: A tannic acid–Fe3+ networks-functionalized polydopamine-based composite nanoparticle was constructed and demonstrated the promising application for T1/T2-weighted MR imaging-guided synergistic treatment of PTT and reductant/photothermal-enhanced CDT.

Cited by 36 publications

References 36 publications

Polydopamine‐Based Nanoparticles for Photothermal Therapy/Chemotherapy and their Synergistic Therapy with Autophagy Inhibitor to Promote Antitumor Treatment

Polydopamine‐Based Nanoparticles for Photothermal Therapy/Chemotherapy and their Synergistic Therapy with Autophagy Inhibitor to Promote Antitumor Treatment

Chemodynamic nanomaterials for cancer theranostics

Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor

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