Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer

Lang, Tianqun; Dong, Xinyue; Zheng, Zhong; Liu, Yiran; Wang, Guanru; Yin, Qi; Li, Yaping

doi:10.1016/j.scib.2018.12.025

Cited by 41 publications

(17 citation statements)

References 39 publications

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“…Moreover, Fig. 1c showed that the hydrodynamic diameter of the NV@CaP-RGD was 29.82 ± 7.16 nm and the polydispersity index (PDI) was 0.175, which contributed to the increasing drug accumulation in tumor tissues via the EPR effect [46]. The NV@CaP-RGD in aqueous solution were negatively charged with a zeta potential of − 7.22 ± 0.39 mV (Additional file 1: Figure S1), which can effectively avoid the reaction with enzymes and proteins in the blood circulation, and improve the stability of NPs in the blood circulation through intravenous administration [47].…”

Section: Resultsmentioning

confidence: 99%

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

Dong¹,

Liao²,

Yu³

et al. 2019

J Nanobiotechnol

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BackgroundMultidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the drug efflux inhibitor verapamil (VRP) and the chemotherapeutic agent novantrone (NVT) synergistically into breast cancer cells to reverse MDR.ResultsThis co-delivery system consists of following components: the active targeting peptide RGD, an inorganic calcium phosphate (CaP) shell and an organic inner core. VRP and NVT were loaded into CaP shell and phosphatidylserine polyethylene glycol (PS-PEG) core of nanoparticles (NPs) separately to obtain NVT- and VRP-loaded NPs (NV@CaP-RGD). These codelivered NPs allowed VRP to prevent the efflux of NVT from breast cancer cells by competitively combining with drug efflux pumps. Additionally, NV@CaP-RGD was effectively internalized into breast cancer cells by precise delivery through the effects of the active targeting peptides RGD and EPR. The pH-triggered profile of CaP was also able to assist the NPs to successfully escape from lysosomes, leading to a greatly increased effective intracellular drug concentration.ConclusionThe concurrent administration of VRP and NVT by organic/inorganic NPs is a promising therapeutic approach to reverse MDR in breast cancer.

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Section: Resultsmentioning

confidence: 99%

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

Dong¹,

Liao²,

Yu³

et al. 2019

J Nanobiotechnol

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“…The AUC (0→ t ) value of the micelles loaded with docetaxel was 3.0-fold higher than the free drug in vivo after intravenous administration [ 122 ]. Lang et al formulated tumor-environment-responsive micelles entrapped with docetaxel for metastatic breast tumor treatment [ 123 ]. These micelles were prepared from amphiphilic copolymer, poly((1,4-butanediol)-diacrylate- b -N,N-diisopropylethylenediamine)-peptide-polyethylene glycol (PEG) (BD-peptide-PEG), matrix metallo-proteinase (MMP)-responsive polymer, and poly((1,4-butanediol)-diacrylate- b -N,N-diisopropyl-ethylenediamine)-polyethyleneimine (BD-PEI).…”

Section: Polymeric Micellesmentioning

confidence: 99%

“…The drug-loaded micelle inhibited primary tumor growth and pulmonary metastasis effectively with a prolonged circulation time. Its efficient uptake into tumor cells is a promising approach for treating metastatic breast cancer [ 123 ].…”

Section: Polymeric Micellesmentioning

confidence: 99%

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Alven

Aderibigbe

2020

Pharmaceutics

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery systems that can overcome the limitations associated with the currently used anticancer drugs. They have the capability to overcome drug resistance, reduce drug toxicity, improve the drug solubility and bioavailability. Different classes of anticancer drugs have been loaded into micelles and dendrimers, resulting in targeted drug delivery, sustained drug release mechanism, increased cellular uptake, reduced toxic side effects of the loaded drugs with enhanced anticancer activity in vitro and in vivo. This review article reports the biological outcomes of dendrimers and micelles loaded with different known anticancer agents on breast cancer in vitro and in vivo.

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“…Through making best use of the enhanced permeability and retention (EPR) effect, nanoparticles (NPs) could more readily localize in tumor tissues than in normal tissues [1][2][3]. The EPR effect is explained by abnormal vessels, in form and architecture, including the poorly organized alignment of endothelial cells and a deficiency of the smooth muscle layer [4].…”

Section: Introductionmentioning

confidence: 99%

Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics

et al. 2019

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Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer

Cited by 41 publications

References 39 publications

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics

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