Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics

Yin, Chunyang; Wang, Shunhao; Ren, Quanzhong; Shen, Xiaowen; Chen, Xiao; Liu, Yajun; Liu, Sijin

doi:10.1016/j.scib.2019.04.017

Cited by 11 publications

(13 citation statements)

References 54 publications

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“…Afterward, 90 μL of supernatant for each sample was dissolved in acid solution containing 1.5% HCl and 0.5% HNO 3 for digestion. The Pd contents in PT and CV specimens were determined by ICP-MS (Agilent 8800, Japan), as previously reported …”

Section: Methodsmentioning

confidence: 99%

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Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver

Feng

Liu

et al. 2019

ACS Nano

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The liver is the primary organ to sequester nanodrugs, representing a substantial hurdle for drug delivery and raising toxicity concerns. However, the mechanistic details underlying the liver sequestration and effects on the liver are still elusive. The difficulty in studying the liver lies in its complexity, which is structured with stringently organized anatomical units called lobules. Graphene oxide (GO) has attracted attention for its applications in biomedicine, especially as a nanocarrier; however, its sequestration and effects in the liver, the major enrichment and metabolic organ, are less understood. Herein, we unveiled the differential distribution of GO in lobules in the liver, with a higher amount surrounding portal triad zones than the central vein zones. Strikingly, liver zonation patterns also changed, as reflected by changes in vital zonated genes involved in hepatocyte integrity and metabolism, leading to compromised hepatic functions. RNA-Seq and DNA methylation sequencing analyses unraveled that GO-induced changes in liver functional zonation could be ascribed to dysregulation of key signaling pathways governing liver zonation at not only mRNA transcriptions but also DNA methylation imprinting patterns, partially through TET-dependent signaling. Together, this study reveals the differential GO distribution pattern in liver lobules and pinpoints the genetic and epigenetic mechanisms in GO-induced liver zonation alterations.

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Section: Methodsmentioning

confidence: 99%

“…The Pd contents in PT and CV specimens were determined by ICP-MS (Agilent 8800, Japan), as previously reported. 70 Extraction and Purification of Hepatocytes. The procedures for hepatocyte isolation and enrichment were conducted following the standard protocols, as previously described.…”

Section: Methodsmentioning

confidence: 99%

Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver

Feng

Liu

et al. 2019

ACS Nano

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“…And we have proved that rESW could effectively improve local blood flow, which could make more oxygen-loaded Nano-PFC deliveries to the wound location and greater oxygen release under rESW treatment. In support of this finding, our latest study uncovered that rESW could promote vessel vasodilation, tumor blood supply, and nanoparticle extravasation into tumor microenvironment [47]. Therefore, we selected the 4T1 tumor-bearing mouse model as an alternative method to evaluate the in vivo behavior of oxygen release and improvement of the hypoxia level as a result of rESW-responsive Nano-PFC.…”

mentioning

confidence: 87%

“…Furthermore, it has been proven that the rESW could induce tissue regeneration and improve blood microcirculation [28,[47][48][49]. Thus, laser Doppler imaging was used to measure the change in blood flow after different treatments.…”

Section: Blood Microcirculation By Laser Doppler Imagingmentioning

confidence: 99%

Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Wang

Yin

Han

et al. 2019

Oxidative Medicine and Cellular Longevity

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Diabetic foot ulcers (DFUs), the most serious complication of diabetes mellitus, can induce high morbidity, the need to amputate lower extremities, and even death. Although many adjunctive strategies have been applied for the treatment of DFUs, the low treatment efficiency, potential side effects, and high cost are still huge challenges. Recently, nanomaterial-based drug delivery systems (NDDSs) have achieved targeted drug delivery and controlled drug release, offering great promises in various therapeutics for diverse disorders. Additionally, the radial extracorporeal shock wave (rESW) has been shown to function as a robust trigger source for the NDDS to release its contents, as the rESW harbors a potent capability in generating pressure waves and in creating the cavitation effect. Here, we explored the performance of oxygen-loaded nanoperfluorocarbon (Nano-PFC) combined with the rESW as a treatment for DFUs. Prior to in vivo assessment, we first demonstrated the high oxygen affinity in vitro and great biocompatibility of Nano-PFC. Moreover, the rESW-responsive oxygen release behavior from oxygen-saturated Nano-PFC was also successfully verified in vitro and in vivo. Importantly, the wound healing of DFUs was significantly accelerated due to improved blood microcirculation, which was a result of rESW therapy (rESWT), and the targeted release of oxygen into the wound from oxygen-loaded Nano-PFC, which was triggered by the rESW. Collectively, the oxygen-saturated Nano-PFC and rESW provide a completely new approach to treat DFUs, and this study highlights the advantages of combining nanotechnology with rESW in therapeutics.

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“…Meanwhile, the flexibility of PEG provides considerable conformational freedom, which was thermodynamically unfavorable to the penetration of foreign matters into PEG corona [ 4 ]. Therefore, PEGylation leads to reduced protein adsorption and clearance in vivo and endows the nanoparticles with prolonged blood circulation time and increased drug accumulation in the target site by the enhanced permeability and retention (EPR) effect [ [4] , [5] , [6] ].…”

Section: Introductionmentioning

confidence: 99%

Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

Jiang

Zou

et al. 2021

Bioactive Materials

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PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect, which consequently improves the intratumoral accumulation. However, cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG, which limits their therapeutic effect. To this end, we designed and prepared two kinds of poly( l -glutamic acid)-cisplatin (PLG-CDDP) nanoformulations with detachable PEG, which is responsive to specific tumor tissue microenvironments for prolonged circulation time and enhanced cell internalization. The extracellular pH (pH e )-responsive cleavage 2-propionic-3-methylmaleic anhydride (CDM)-derived amide bond and matrix metalloproteinases-2/9 (MMP-2/9)-sensitive degradable peptide PLGLAG were utilized to link PLG and PEG, yielding pH e -responsive PEG- pH e -PLG and MMP-sensitive PEG- MMP -PLG. The corresponding smart nanoformulations PEG- pH e -PLG-Pt and PEG- MMP -PLG-Pt were then prepared by the complexation of polypeptides and cisplatin (CDDP). The circulation half-lives of PEG- pH e -PLG-Pt and PEG- MMP -PLG-Pt were about 4.6 and 4.2 times higher than that of the control PLG-Pt, respectively. Upon reaching tumor tissue, PEG on the surface of nanomedicines was detached as triggered by pH e or MMP, which increased intratumoral CDDP retention, enhanced cell uptake, and improved antitumor efficacy toward a fatal high-grade serous ovarian cancer (HGSOC) mouse model, indicating the promising prospects for clinical application of detachable PEGylated nanoformulations.

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Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics

Cited by 11 publications

References 54 publications

Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver

Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver

Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave

Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

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