2017
DOI: 10.1515/med-2017-0035
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Tumor microenvironment in treatment of glioma

Abstract: AbstractGlioma is one of the most malignant and fatal tumors in adults. Researchers and physicians endeavor to improve clinical efficacy towards it but made little achievement. In recent years, people have made advances in understanding characteristics and functions of tumor microenvironment and its role in different processes of tumor. In this paper, we describe the effects of tumor microenvironment on glioma proliferation, invasion and treatments. By explaining underlying mec… Show more

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Cited by 46 publications
(48 citation statements)
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“…GBM patients usually have a median survival of approximately 15 months with the “Stupp” Regimen, consisting of 6 weeks of radiation with daily Temozolomide (TMZ) followed by 6 cycles of TMZ [ 2 , 3 ]. However, despite the modern therapies, GBM patients still have poor prognosis and high tumor recurrence due to the tumor resistance to chemotherapy [ 4 , 5 ]. TMZ, a DNA alkylating agent, is currently the most widely used and effective chemotherapeutic drug for GBM [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…GBM patients usually have a median survival of approximately 15 months with the “Stupp” Regimen, consisting of 6 weeks of radiation with daily Temozolomide (TMZ) followed by 6 cycles of TMZ [ 2 , 3 ]. However, despite the modern therapies, GBM patients still have poor prognosis and high tumor recurrence due to the tumor resistance to chemotherapy [ 4 , 5 ]. TMZ, a DNA alkylating agent, is currently the most widely used and effective chemotherapeutic drug for GBM [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…The tumor microenvironment has a crucial role in cancer development, progression, and response to treatment [ 5 ]. The GBM microenvironment does not only contain tumor cells but also a mixture of diverse stromal cell types.…”
Section: Introductionmentioning
confidence: 99%
“…Glioma microenvironment is composed by a multitude of chemokines, interleukins, growth factors, and proinflammatory small molecules. These growth factors stimulate several oncogenes such as PKB, mTOR, and STATs (Audia, Conroy, Glass, & Bhat, 2017;Li et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Glioblastoma represents a prototype of tumor in which the remarkable capability of communication with the microenvironment and the complex intra- and inter-tumor heterogeneity play a leading role in tumor malignancy, invasiveness and therapy failure. The interaction of tumor-glia cells is also linked with the chemoresistant phenotype of glioblastoma [ 5 ]; in particular, the hypoxic microenvironment, a common feature of this type of cancer, is strongly associated with radio- and chemoresistance by modulating different mechanisms, such as apoptosis and angiogenesis [ 6 ], expression of ATP-binding cassette (ABC) proteins [ 7 ], and functions of glioblastoma stem cells (GSCs) [ 8 ].…”
Section: Introductionmentioning
confidence: 99%