Tumor Microenvironment–Associated Pericyte Populations May Impact Therapeutic Response in Thyroid Cancer

Iesato, Asumi; Nucera, Carmelo

doi:10.1007/978-3-030-73119-9_14

Cited by 13 publications

(7 citation statements)

References 136 publications

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“…Surgery, radiation, and drugs can change our cell microenvironment. Surgery can alter the human tumour microenvironment 27 , as can radioactivity 28,29 . Drugs can also induce changes in the tumour microenvironment, even ones leading to drug resistance 30,31 .…”

Section: Discussionmentioning

confidence: 99%

Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics

Xiao

Yang

Wang

et al. 2023

Preprint

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Glioma is a type of tumour that starts in the glial cells of the brain or the spine. Since the 1800s, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrence and the underlying mechanism. Medical doctors remain stymied regarding tumour recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒ function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for glioma.

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Section: Discussionmentioning

confidence: 99%

Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics

Xiao

Yang

Wang

et al. 2023

Preprint

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“…Surgery, radiation, and drugs can change our cell microenvironment. Surgery can alter the human TME 22 , as can radioactivity 23,24 .…”

Section: Discussionmentioning

confidence: 99%

Preliminary Exploration of Structure–Function Crosstalk in Colorectal Cancer Research: Protein Structuromics

Nan

Zhang

et al. 2023

Preprint

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Colorectal cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrenceand the underlyingmechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for CRC.

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“…[26] Tumor microenvironment has been increasingly demonstrated as a major regulator of tumorigenesis and drug resistance. [27,28] A growing number of studies have focused on identifying biomarkers in tumor microenvironment to predict clinical outcome and guide therapy in TNBC. [7][8][9] The stromal tumor infiltrating immune cells, especially the TILs, has been documented as the prognostic indicator in predicting response to therapy in TNBC.…”

Section: Discussionmentioning

confidence: 99%

High expression of MORC2 predicts worse neoadjuvant chemotherapy efficacy in triple negative breast cancer

Liao,

Liu,

Ding

et al. 2023

Medicine

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Tumor infiltrating lymphocytes (TILs) are closely related to the patients’ prognosis. Recently, Microrchidia 2 (MORC2) has been documented as a prognostic and predictive biomarker in triple negative breast cancer (TNBC). To compare whether MORC2 is a better predictor than TILs, as well as clinicopathological parameters, in predicting the efficacy of neoadjuvant chemotherapy (NAC) in TNBC, we detected the expression of MORC2 on neoplastic cells through immunohistochemistry and quantified the stromal TILs through Hematoxylin-eosin staining on core biopsies from 50 locally advanced TNBC patients who underwent standard NAC. Among all the 50 patients, 28 (56%) cases had residual tumors, while the other 22 (44%) achieved pathologic complete response (pCR). In these studied patients, age and T-stage showed no correlation with pCR rate, while percentage of TILs, nodal involvement and expression of MORC2 on tumor cells showed significant association with pCR rate. Positive nodal involvement was correlation with worse pathologic response at multivariate analysis (P = .0036), and high TILs levels (≥50%) was positively associated with better NAC efficacy at univariate analysis (P = .002). Whereas high expression of MORC2 was statistically associated with worse pCR rate both at univariate (P < .001) and multivariate (P = .036) analysis. Our results indicate that MORC2 expression has a better predictive role in predicting the efficacy of NAC than TILs in TNBC patients.

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Tumor Microenvironment–Associated Pericyte Populations May Impact Therapeutic Response in Thyroid Cancer

Cited by 13 publications

References 136 publications

Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics

Preliminary Exploration of Structure‒Function Crosstalk in Glioma: Protein Structuromics

Preliminary Exploration of Structure–Function Crosstalk in Colorectal Cancer Research: Protein Structuromics

High expression of MORC2 predicts worse neoadjuvant chemotherapy efficacy in triple negative breast cancer

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