Tumor markers

Newsom, Barry D.; Hardy, James D.

doi:10.1016/0011-3840(82)90016-8

Cited by 12 publications

(5 citation statements)

References 135 publications

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“…These alterations can potentially be used as clinical markers to define a particular disease entity, useful for diagnosis, staging, population screening or even to detect the presence of occult metastatic disease, recurrent disease and response to treatment. The perhaps most known embryonic protein used as a tumor marker in malignancy is the CEA in colorectal cancer [ 7 ]. In an attempt to identify additional genes altered during the development of colorectal cancer, we compared the gene expression pattern between normal colon epithelium samples and colorectal tumors using the mRNA differential display PCR (mRNA DD-PCR) method.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors

et al. 2001

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BackgroundThe gene expression pattern in tumor cells differs from that in corresponding normal cells. In order to identify differentially expressed genes in colorectal tumors and normal colorectal epithelium, a differential display experiment was used to compare RNA expression in normal and tumor tissue samples.ResultsOne gene fragment was expressed only in normal tissue and not, or to a much lesser extent, in the adenomas, carcinomas and cancer cell lines. The isolated gene fragment was identical to Aquaporin 8 (AQP8), a water channel protein. In situ hybridization demonstrated that AQP8 was expressed in the cells facing the lumen in the normal colonic epithelium.ConclusionOur result suggests that the expression of AQP8 is a marker of normal proliferating colonic epithelial cells and suggest these cells to be involved in fluid transport in the colon.

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Section: Introductionmentioning

confidence: 99%

Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors

et al. 2001

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“…Subsequently, GEORGE et al [162] demonstrated in vitro biosynthesis of ADH in short-term culture of lung cancer. Other malignancies with ectopic secretion of ADH include: bronchial carcinoid tumours, adenocarcinoma of the pancreas, Hodgkin's disease, bladder carcinoma, thymoma, mesothelioma, leiomyosarcoma of the stomach, prostatic carcinoma, and adrenocortical cancer [163].…”

Section: Antidiuretic Hormonementioning

confidence: 99%

Serum tumour markers in lung cancer: history, biology and clinical applications

Ferrigno¹,

Buccheri²,

Biggi³

1994

Eur Respir J

102

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S Se er ru um m t tu um mo ou ur r m ma ar rk ke er rs s i in n l lu un ng g c ca an nc ce er r: : h hi is st to or ry y, , b bi io ol lo og gy y a an nd d c cl li in ni ic ca al l a ap pp pl li ic ca at ti io on ns s Several tumour markers have been studied in lung cancer. Unfortunately, none of these appear to be sufficiently sensitive and specific to be reliable for screening and diagnostic purposes. However, there is a body of evidence which proves that at least some of these substances may be useful in the evaluation of the course and prognosis of the disease.This review presents data concerning the most studied and interesting tumour markers in lung cancer.

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“…The sensitivity of CEA is low (elevated in 30-38% of Dukes' A and B colorectal cancers and in 75-85% of Dukes' C colorectal cancers) and it lacks specificity, therefore it is not useful as a diagnostic test [12]. Since recurrences occur in up to 50% of patients with Dukes' B and C colorectal can cers, CEA has been found most useful in the monitoring of these patients.…”

Section: Carcinoembryonic Antigenmentioning

confidence: 99%

Management of Recurrent Colorectal Cancer: Another Look at Carcinoembryonic Antigen-Detected Recurrence

Vauthey

Dudrick

Lind

et al. 1996

Dig Dis

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There is currently controversy regarding the use of serum carcinoembryonic antigen (CEA) in the follow-up of colorectal cancer. This article reviews the most recent clinical data regarding CEA and discusses the rationales for its use in the follow-up of colorectal cancer. The patterns of colorectal cancer recurrence and their variable association with CEA elevation are presented. The contributions of the new imaging modalities, including radiolabeled antibodies, are reviewed end information on the prognosis following resection of recurrences is provided. A practical approach to colorectal cancer recurrences is suggested in two algorithms.

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Tumor markers

Cited by 12 publications

References 135 publications

Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors

Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors

Serum tumour markers in lung cancer: history, biology and clinical applications

Management of Recurrent Colorectal Cancer: Another Look at Carcinoembryonic Antigen-Detected Recurrence

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