Tumor inhibitors. XLVII. Vernodalin and vernomygdin, two new cytotoxic sesquiterpene lactones from Vernonia amygdalina del

Kupchan, S. Morris; Hemingway, R.J.; Karim, Aditya Krishar; Werner, D.

doi:10.1021/jo01264a035

Cited by 153 publications

(99 citation statements)

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“…The organic fraction extracts of the plant was shown to possess cytotoxic effects towards human carcinoma cells of the nasopharynx. [34] It is effective against amoebic dysentery [35], gastrointestinal disorders, [36] , and has antimicrobial and antiparasitic activities.…”

Section: Plant Description and Usagementioning

confidence: 99%

Comparative Study of Mild Steel Corrosion Inhibition of Piper Guineense Leaves Extract and Vernonia Amygdalina Leaves Extract in Concentrated Corrosive Medium

Ibisi¹,

Okoroafor²,

Amuta³

2017

IOSR JAC

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Section: Plant Description and Usagementioning

confidence: 99%

Comparative Study of Mild Steel Corrosion Inhibition of Piper Guineense Leaves Extract and Vernonia Amygdalina Leaves Extract in Concentrated Corrosive Medium

Ibisi¹,

Okoroafor²,

Amuta³

2017

IOSR JAC

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“…The preliminary phytochemical analysis of the aqueous extract of the roots of Vernonia amygdalina revealed the presence of carbohydrates, tannins, glycosides, flavonoids, phlobatannins, steroids, terpenoids and saponnins (Kupcham et al, 1969).…”

Section: Phytochemical Screening:-mentioning

confidence: 99%

Hepatotoxicity of the Aqueous Extract of the Roots of Vernonia Amygdalina Delile (Asteraceae) in Rats.

Nwonu¹,

Nwonu²,

Aniche³

2017

IJAR

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“…and cancer. 16 Various parts of the plant Vernonia cinerea have been used as antimalarial, astringent, antidiarrhoeal and antiviral agent. 17 Literature evidences reveal that the root decoction and stem of V. cinerea have been used in the treatment of diabetes mellitus and human breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

Sridharan¹,

Venkatramani²,

Janakiraman³

et al. 2016

IJPER

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Context:The therapeutic potential of the genus Vernonia has been well documented over the years. However the pharmacological potential of the plant Vernonia arborea (Asteraceae) has been relatively less explored. Objective: To investigate the antiinflammatory effect of the ethanol leaf extract of V. arborea against formalin induced inflammation in rats. Materials and methods: Formalin induced inflammation method was used to induce inflammation in rats.0.1 ml/kg body weight (b.w.) of formalin was administered to the rats via sub-plantar injection to induce inflammation. The rats were pretreated with ethanol leaf extract of V. arborea at concentrations of 100, 200 and 300 mg/kg b.w. once daily for 30 days. Indomethacin (25 mg/kg b.w.) was used as standard drug. Biochemical and hematological parameters along with levels of antioxidant enzymes were evaluated. Results: Administration of formalin reduced antioxidant enzyme levels, total RBC and Hb. Pretreatment with ethanol leaf extract of V.arborea at dose dependent levels significantly increased (p<0.05)the levels of the above parameters. A significant increase (p<0.05) in paw thickness, level of serum enzymes (Aspartate transaminase, Alanine transaminase, Alkaline phosphatase and Creatine kinase), Lipid peroxide and leucocytes was observed in the rats induced with formalin, while these levels were normalized on pretreatment with ethanol leaf extract of V.arborea. Conclusion: The results of the present investigation demonstrate the antioxidant and anti-inflammatory potential of the ethanol leaf extract of V.arborea. However, it is imperative to isolate and purify the active principles involved in the pharmacological potency of this plant and determine its mechanism of action.

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Tumor inhibitors. XLVII. Vernodalin and vernomygdin, two new cytotoxic sesquiterpene lactones from Vernonia amygdalina del

Cited by 153 publications

References 0 publications

Comparative Study of Mild Steel Corrosion Inhibition of Piper Guineense Leaves Extract and Vernonia Amygdalina Leaves Extract in Concentrated Corrosive Medium

Comparative Study of Mild Steel Corrosion Inhibition of Piper Guineense Leaves Extract and Vernonia Amygdalina Leaves Extract in Concentrated Corrosive Medium

Hepatotoxicity of the Aqueous Extract of the Roots of Vernonia Amygdalina Delile (Asteraceae) in Rats.

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

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