Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC

Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum

“…Pectolinarigenin and pectolinarin were also found to be the constituents of other Compositae family members 33) ; isolated from C. japonicum DC they inhibited tumor formation in mice. 34) Pectolinarin was previously found to possess in vivo anti-inflammatory and analgesic activities. 35) Recently, pectolinarigenin and pectolinarin isolated from C. setidens were demonstrated to reduce galactosamine-induced hepatic injury in rats.…”

Medicinal Plants for Treatment of Cancer: A Brief Review

“…Furthermore, the anticancer activity of the two flavones in S180 and H22 mice was studied and these two flavones greatly inhibited cancer cell growth, and increased the life span. [57][58][59] Cephalotaxus harringtonia Several phytochemicals obtained from the chloroform extract of leaves and stems of Cephalotaxus harringtonia (Cephalotaxaceae) are cephalotaxine and its antitumor esters (harringtonine, isoharringtonine and homoharringtonine) in both callus and medium. It shows significant activity against experimental P388 leukemia and L-121O leukemia in mice.…”

Determination of pectolinarin inCirsiumspp. using HPLC/UV analysis

“…contains various phytochemicals, including flavonoids, phenolic acids, lignans, polyacetylenes, acetylenes, sterols, triterpenes, susquiterpene lactones, and alkaloids (Lee et al 1994;JordonThanden and Louda 2001;Chung et al 2002;Yim et al 2003;Jeong et al 2008). The flavonoids include compounds such as pectolinarin, luteolin, linarin, hispidulin-7-neohesperidoside, pectolinarigenin, apigenin, quercetin, luteolin 5-O-glucoside, and 5,7-dihydroxy-6,4-dimethoxy flavones (Ganzera et al 2005;Liu et al 2006;Jung et al, 2012;Sun et al 2012). C. setidens is distributed mainly in the mountainous regions of Kangwon Province, Korea .…”