Tumor hypoxia relief overcomes multidrug resistance and immune inhibition for self-enhanced photodynamic therapy

He, Yuchu; Cong, Cong; He, Yaqian; Hao, Zining; Li, Chunhui; Wang, Shuai; Zhao, Qianqian; He, Hong; Zhu, Ruiyan; Li, Xiaoling; Gao, Dawei

doi:10.1016/j.cej.2019.122079

Cited by 76 publications

(43 citation statements)

References 29 publications

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“…MTT is commonly used method to evaluate the cytotoxicity of nanoparticles. [47][48][49] As illustrated in Fig. 8, the cell viability was higher than 90% aer incubation with Pd n -LNT NPs and LNT at a concentration within 1000 mg mL À1 .…”

Section: Biocompatibilitymentioning

confidence: 90%

Green synthesis of palladium nanoparticles using lentinan for catalytic activity and biological applications

et al. 2019

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Section: Biocompatibilitymentioning

confidence: 90%

Green synthesis of palladium nanoparticles using lentinan for catalytic activity and biological applications

et al. 2019

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“…First, the generation of ROS by either PDT or SDT for most sensitizers relies on the presence of O 2 in the medium. However, tumors are commonly hypoxic, which makes ROS generation ineffective [ 5 , 6 ]. Hypoxia is a characteristic hallmark of the microenvironment in solid tumors, resulting on one side from upregulated metabolism, especially in fast-growing aggressive tumors, and on the other side, from insufficient oxygenation through aberrant blood vessels [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

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“…Lin et al designed a novel up-conversion luminescence (UCL)-enhanced spindle-shaped nanocomposite for mitochondrial imaging that is coated with gold nanoparticles for PDT (SPS@Au), and is combined with anti-CTLA-4 mAb for photodynamic immunotherapy 99 . Recently, multifunctional nanoparticles have been developed to synergize PDT, chemotherapy, and immunotherapy, such as a TME-triggered oxygen nanogenerator PTX/ICG-NVs@Au@CAT 100 . In this nanoconstruct, H 2 O 2 is catalyzed to oxygen by CAT to relieve tumor hypoxia, enhancing ROS generation by ICG-PDT, which potentiates the efficacy of immunotherapy.…”

Section: Photodynamic Immunotherapymentioning

confidence: 99%

Cancer photo-immunotherapy: from bench to bedside

Wang¹,

Rao²,

Wang³

et al. 2021

Theranostics

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Tumor hypoxia relief overcomes multidrug resistance and immune inhibition for self-enhanced photodynamic therapy

Cited by 76 publications

References 29 publications

Green synthesis of palladium nanoparticles using lentinan for catalytic activity and biological applications

Green synthesis of palladium nanoparticles using lentinan for catalytic activity and biological applications

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Cancer photo-immunotherapy: from bench to bedside

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