Tumor Frequencies and Contaminant Concentrations in Brown Bullheads from an Industrialized River and a Recreational Lake

Baumann, Paul C.; Smith, William D.; Parland, William K.

doi:10.1577/1548-8659(1987)116<79:tfacci>2.0.co;2

Cited by 94 publications

(47 citation statements)

References 13 publications

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“…Baumann et al (1987) demonstrated an increased frequency of liver tumours with age in brown bullheads Ictalurus nebulosus and also that 4 to 5 yr old fish had a significantly higher prevalence of biliary carcinomas than 2 to 3 yr old ones collected at the same site (Baumann et al 1990). Furthermore, the latter study demonstrated a relative lack (or even absence) of fish of age ≥ 5 yr at sites with the highest liver tumour prevalence, suggesting an age-selective mortality associated with the disease (Baumann et al 1990).…”

Section: Introductionmentioning

confidence: 66%

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Stentiford¹,

Bignell²,

Lyons³

et al. 2010

Mar. Ecol. Prog. Ser.

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Age at disease onset, a familiar concept in human medicine, has not been commonly discussed in relation to diseases of wildlife. Furthermore, while age has been anecdotally linked with disease susceptibility in aquatic animals (e.g. in aquaculture), little attention has been devoted to health of specific cohorts in wild aquatic animal populations. In an attempt to refine current approaches to marine environmental monitoring programmes that utilise fish diseases as a sentinel for ecological status, we have investigated age at onset for 10 disease variables in the flatfish Limanda limanda, a commonly utilised species in such programmes in Europe. By comparing the prevalence of these variables (including several associated with liver neoplasia) in different age classes from the same sites, we have demonstrated an increased propensity for 'harm' (a cumulative measure of multiple disease variables) with age. Furthermore, a comparison of age-matched cohorts from geographically distinct offshore marine sites revealed that this tendency for increased harm differs in magnitude between sites. In these scenarios, the age at onset for key disease variables (such as pre-neoplastic and neoplastic pathologies of the liver) also differs between sites, with some locations containing populations with apparently increased susceptibility in younger age classes. We conclude that while age is an important variable when assessing fish population health status, it does not explain all of the differences in disease prevalence observed in natural populations, and further, that age-matched cohorts from certain populations have a higher propensity for disease than fish of the same age from other sites. The basis for these differences in susceptibility is discussed in relation to the prevailing burden of anthropogenic contaminants and to other natural factors (such as population genetics and migration) inherent in sampled populations.

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Section: Introductionmentioning

confidence: 66%

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Stentiford¹,

Bignell²,

Lyons³

et al. 2010

Mar. Ecol. Prog. Ser.

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show abstract

“…Associations between contaminant levels and neoplastic diseases have been made in several aquatic species (13)(14)(15)(16)(17)(18) (20,21). Similarly, a wide variety of chemical contaminants are known to disrupt immune system functions (22)(23)(24).…”

Section: Do Environmental Contaminants Play a Role In Gtfp?mentioning

confidence: 99%

Green turtle fibropapillomatosis: challenges to assessing the role of environmental cofactors.

Herbst

Klein

1995

Environ Health Perspect

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Green turtle fibropapillomatosis (GTFP) is a growing threat to the survival of green turtle (Chelonia mydas) populations worldwide. Recent transmission studies point to an infectious etiology. Several field studies suggest that high GTFP prevalence is associated with marine habitats that have been impacted by agricultural, industrial, or urban development. Environmental contaminants could be involved in GTFP through several plausible mechanisms including cocarcinogenesis and contaminant-induced immune suppression. However, an association of contaminants with GTFP has not been established. A broader perspective is needed when studying infectious diseases such as GTFP in complex ecosystems. Alternative explanations for high GTFP prevalence in some near-shore habitats include the following: a) these habitats provide an optimum physical environment for survival and transmission of the infectious agent; b) these habitats attract a high density of susceptible turtles or harbor a higher density of potential vectors, facilitating transmission of the pathogen in a density-dependent fashion; and c) these habitats may contain other stressors that render turtles more susceptible to GTFP. Application of scientifically rigorous criteria in the epizootiology of GTFP in free-ranging populations remains a formidable challenge. -Environ Health Perspect 1 03(Suppl 4): 27-30 (1995)

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“…Bile from such bullheads exhibits fluorescent metabolites resulting from the metabolism ofPAHs (18). Baumann has suggested that PAHs are the most likely carcinogens to be responsible for the high rate ofliver tumors in brown bullheads in contaminated environments (19 (20).…”

Section: Effects Of Pahs On Aquatic Organismsmentioning

confidence: 99%

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Dunn¹

1991

Environmental Health Perspectives

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In anorganim with actrve nmtaboc systems for a given carcinogen, adducts are generally much longer lived than the carcinogens that formed them. Thus, the detection ofDNA-or protdn-carcinogen adductsin aquatic foodstuffs can act as anindicatorofprior carnog exposur The presnee ofDNA adducts would, in addition, suggest a mutagenic/carcinogenic risk to the aquatic orn itself. Wrtebrate fish are chacterized by high levels ofcarcinogen metabolism, low body burdens ofcarcinogen, the formation ofcarcinogen-macromolecule adducs, and theoccurrence ofpollutionrelated tumor Shellfish, on the other hand, h elowlevesofcarclnogenmetabos, high body burdens ofarcinogen, and have little or no evidence ofcarcinogen-macromolecule adductsor tums Th consumpton ofcarcinogen adducts in aquatic foodt Is unlkely to reprent a human helth hazard. There are no metaboik pathways by which proteincarcinogen or DNA-carcinogen adducts could reform carcnogen Incorporation via salage pathways of prformed mucleoside-carcinogen adducts from fo ts into newly syntbeized human DNA is theo lly ponsihIe However, absolute levelsofnucleoside-carcinogen leves in aquatic foodstuffs from polluted areas arevery low, and the incorporation of peormed adducts into DNA is songly discrminated against by the fidelity of DNA synthesis.

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Tumor Frequencies and Contaminant Concentrations in Brown Bullheads from an Industrialized River and a Recreational Lake

Cited by 94 publications

References 13 publications

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Green turtle fibropapillomatosis: challenges to assessing the role of environmental cofactors.

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

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