Tumor-facing hepatocytes significantly contribute to mild hyperthermia-induced targeting of rat liver metastasis by PLGA-NPs

Castellani, Chiara; Fedrigo, Marny; Tavano, Regina; Cappellini, Rekha; Fedeli, Chiara; Mognato, Maddalena; Abdel-Mottaleb, Mona M.A.; Lamprecht, Alf; Tudorancea, Ionuț; Porumb, Vlad; Iliescu, Radu; Angelini, Annalisa; Papini, Emanuele; Dimofte, Gabriel

doi:10.1016/j.ijpharm.2019.06.004

Cited by 9 publications

(3 citation statements)

References 22 publications

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“…The most prominent nanoparticles are metallic nanoparticles that provide great contrast in MRI imaging. Given the high prevalence of macrophages within solid tumors, these nanoparticles are also used to detect tumor metastasis [32][33][34]. Nanoparticles are conjugated with mannose [35][36][37] to enhance uptake in monocyte, macrophage, and dendritic cell populations.…”

Section: Plos Onementioning

confidence: 99%

Exploratory mapping of tumor associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach

Brown,

Bilynsky,

Gainey

et al. 2024

PLoS ONE

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The role of macrophages in regulating the tumor microenvironment has spurned the exponential generation of nanoparticle targeting technologies. With the large amount of literature and the speed at which it is generated it is difficult to remain current with the most up-to-date literature. In this study we performed a topic modeling analysis of 854 abstracts of peer-reviewed literature for the most common usages of nanoparticle targeting of tumor associated macrophages (TAMs) in solid tumors. The data spans 20 years of literature, providing a broad perspective of the nanoparticle strategies. Our topic model found 6 distinct topics: Immune and TAMs, Nanoparticles, Imaging, Gene Delivery and Exosomes, Vaccines, and Multi-modal Therapies. We also found distinct nanoparticle usage, tumor types, and therapeutic trends across these topics. Moreover, we established that the topic model could be used to assign new papers into the existing topics, thereby creating a Living Review. This type of “birds-eye-view” analysis provides a useful assessment tool for exploring new and emerging themes within a large field.

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Section: Plos Onementioning

confidence: 99%

Exploratory mapping of tumor associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach

Brown,

Bilynsky,

Gainey

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The most prominent nanoparticles are metallic nanoparticles that provide great contrast in MRI imaging. Given the high prevalence of macrophages within solid tumors, these nanoparticles are also used to detect tumor metastasis [31]- [33]. Nanoparticles are conjugated with mannose [34]- [36] to enhance uptake in monocyte, macrophage, and dendritic cell populations.…”

Section: Imagingmentioning

confidence: 99%

Meta-analysis of macrophage nanoparticle targeting across blood and solid tumors using an eLDA Topic modeling Machine Learning approach

Brown

Bilynsky

Gainey

et al. 2023

Preprint

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The role of macrophages in regulating the tumor microenvironment has spurned the exponential generation of nanoparticle targeting technologies. With the large amount of literature and the speed at which it is generated it is difficult to remain current with the most up-to-date literature. In this study we performed a topic modeling analysis of the most common usages of nanoparticle targeting of macrophages in solid tumors. The data spans 20 years of literature, providing an extensive meta-analysis of the nanoparticle strategies. Our topic model found 6 distinct topics: Immune and TAMs, Nanoparticles, Imaging, Gene Delivery and Exosomes, Vaccines, and Multi-modal Therapies. We also found distinct nanoparticle usage, tumor types, and therapeutic trends across these topics. Moreover, we established that the topic model could be used to assign new papers into the existing topics, thereby creating a Living Review. This type of meta-analysis provides a useful assessment tool for aggregating data about a large field.

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“…A large number of studies have proved that high temperature combined with various anticancer drugs or radiotherapy can more effectively inhibit tumor cell growth and increase tumor cell death [30]. At the same time, mild hyperthermia (41-42℃) can increase the phagocytosis of tumor cells to nanoparticles [31]. Hyperthermia can also affect tumor growth and metastasis by affecting the immune function of the body.…”

Section: Effects Of Hyperthermia On Tumorsmentioning

confidence: 99%

Research Progress on the Relationship between Temperature and Tumor Growth and Metastasis

2022

JCMP

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Tumor growth and metastasis are affected by many factors, among which temperature change can directly or indirectly affect tumor growth and metastasis. Temperature can affect tumor growth and metastasis by affecting tumor cells, tumor microenvironment and immune capacity. Some studies have proved that the regulation of local or overall body temperature and external environment temperature can affect tumor growth and metastasis, and some research results have been applied to clinical tumor treatment, such as hyperthermia. Accurate regulation of body temperature and external temperature is a positive and effective direction to inhibit tumor growth and prevent tumor metastasis. In this review, we reviewed the research progress on the relationship and regulation mechanism between temperature and tumor growth and metastasis.

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Tumor-facing hepatocytes significantly contribute to mild hyperthermia-induced targeting of rat liver metastasis by PLGA-NPs

Cited by 9 publications

References 22 publications

Exploratory mapping of tumor associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach

Exploratory mapping of tumor associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach

Meta-analysis of macrophage nanoparticle targeting across blood and solid tumors using an eLDA Topic modeling Machine Learning approach

Research Progress on the Relationship between Temperature and Tumor Growth and Metastasis

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