Tumor extragonadal de células germinales con fenómeno “burned-out” en testículo

Calvo, Alfonso; Alonso, Andrés Rodríguez; Garcia, Dairon; Freire, Filipa; Rodrigo, Andrés; Iglesias, B. Rodríguez; Delgado, J. Benavente; Rodríguez, J.M. Barros; Valverde, Concepción Fiaño; March, J.L. Nogueira

doi:10.1016/s0210-4806(99)72389-2

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Infrequently, testicular GCT can regress spontaneously after its metastatic spread to the lymph nodes. This phenomenon is called “burned-out.” Microscopically, testicular GCT can be completely or partially burned out [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…A burned-out testicular tumor refers to the presence of a metastatic extragonadal GCT with histological regression of the primary testicular lesion [ 4 , 5 ]. Histological features that are helpful to define a diagnosis of a burned-out testicular GCT include scar formation, intratubular calcifications, lymphoplasmacytic infiltrate, hemosiderin-containing macrophages, and testicular atrophy [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Choriocarcinoma is most likely to burn out, followed by embryonal carcinoma; regression is uncommon in testicular seminoma and probably does not occur in teratoma [ 4 ]. We report a case with partial burned-out testicular mixed GCT that metastasized to the retroperitoneal and mediastinal area.…”

Section: Introductionmentioning

confidence: 99%

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Burned-Out Testicular Cancer: Really a Different History

et al. 2017

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Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. To our knowledge, there are no cases of the burned-out phenomenon in teratoma. We report a case of a 19-year-old man presenting to our institute with a right testicular lesion, evidence of mediastinal and abdominal lymph node metastasis, and high levels of GCT serum biomarkers. After orchiectomy, the histopathological examination showed a mixed GCT: mature teratoma, immature teratoma, and histological features of testicular cancer regression (burned-out phenomenon). The patient underwent first-line chemotherapy (BEP regimen) which resulted in a complete instrumental and biochemical response after 4 cycles. Teratoma is considered a less aggressive type of GCT. In this particular case, metastatic disease seems to result from non-germ cell components which underwent early spontaneous regression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Burned-Out Testicular Cancer: Really a Different History

et al. 2017

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Gastrointestinal bleeding as the first manifestation of a burned-out tumour of the testis

et al. 2005

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We discuss the clinical presentation and course of the disease of a 25-year-old male who had gastrointestinal (GIT) symptoms secondary to retroperitoneal lymph node proliferation of a germ-cell tumour of the testis. The pathology evaluation of the orchiectomy specimen classified it as a burned-out tumour of the testis, given the lack of tumour elements and the presence of typical scarring tissue. Biological is-sues leading to tumour regression are discussed, as well.

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“Burned out” testicular seminoma presenting as a primary gastric malignancy

Mesa¹,

Rawal²,

Rezcallah

et al. 2009

Int J Clin Oncol

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In contrast to primary gastric adenocarcinomas, germ cell tumors are potentially curable even when metastatic. It is therefore essential for clinicians and pathologists to be aware of the spectrum of unusual manifestations of germ cell malignancies. Here we report on a 55-year-old man who presented with clinical and endoscopic features indicative of a primary gastric carcinoma. Surprisingly, the ulcerative mucosal lesion was found to be due to a metastasis from an occult, "burned-out" testicular seminoma. This case describes the radiological and pathological features that helped differentiate this rare situation from the much more common gastric adenocarcinoma, and extends the diagnostic possibilities that must be considered in patients presenting with gastric ulcers.

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Tumor extragonadal de células germinales con fenómeno “burned-out” en testículo

Cited by 14 publications

References 7 publications

Burned-Out Testicular Cancer: Really a Different History

Burned-Out Testicular Cancer: Really a Different History

Gastrointestinal bleeding as the first manifestation of a burned-out tumour of the testis

“Burned out” testicular seminoma presenting as a primary gastric malignancy

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