“Burned out” testicular seminoma presenting as a primary gastric malignancy

Mesa, Hector; Rawal, Ajay; Rezcallah, Anthony; Iwamoto, Carlos; Niehans, Gloria A.; Druck, Paul; Gupta, Pankaj

doi:10.1007/s10147-008-0804-0

Cited by 11 publications

(13 citation statements)

References 23 publications

(37 reference statements)

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“…Testis tumor markers that are within the normal range could not be relied on to establish the diagnosis. To our knowledge, this is the largest series of this rare entity, as the literature only contains 25 instances that have been reported either as case reports or as small cohorts . Only one of these cases involved nonmetastatic disease .…”

Section: Discussionmentioning

confidence: 98%

Burned-Out Testis Tumors in Asymptomatic Infertile Men: Multiparametric Sonography and MRI Findings

et al. 2016

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Multiparametric testicular ultrasound and magnetic resonance imaging (MRI) findings were analyzed in a series of 10 infertile asymptomatic men presenting with pathologically confirmed burned-out testicular tumors. Color/power Doppler ultrasound (CDUS), shear wave elastography (SWE), contrast-enhanced ultrasonography (CEUS), and MRI were performed on 10, 5, 6, and 7 patients, respectively. All lesions appeared as a hypoechoic and hypovascular nodular area at CDUS, SWE, CEUS CDUS, and CEUS (if performed). Shear wave elastography showed a stiffer nodular area compared with the surrounding/contralateral tissues (13 versus 2 kPa); MRI revealed a well-delineated nodular area in hypointense signal on T2, a high apparent diffusion coefficient value, and a lack of enhancement.

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Section: Discussionmentioning

confidence: 98%

Burned-Out Testis Tumors in Asymptomatic Infertile Men: Multiparametric Sonography and MRI Findings

et al. 2016

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“…The differential diagnosis of 18F-FDG uptake in the stomach includes more common benign entities such as physiological uptake [12]; gastritis (with or without H. pylori involvement) [13]; and malignant entities. These malignant entities include gastric adenocarcinoma [14], signet ring cell carcinoma [15], diffuse large B-cell lymphoma [16], MALT lymphoma [17], primary mediastinal B-cell lymphoma [18], neuroendocrine tumour [19], gastrointestinal stromal tumour (GIST) [20] and metastases [21]. …”

Section: Discussionmentioning

confidence: 99%

“…, normal levels 120-160 g l 21 ). An endoscopy showed a fungating, ulcerated and actively bleeding lesion in the greater curvature of the stomach.…”

mentioning

confidence: 94%

Gastric recurrence of a primary colon plasmacytoma: staging and evaluating response to therapy with 18F-FDG PET/CT

Makis¹,

Ciarallo²,

Hickeson³

et al. 2012

BJR

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ABSTRACT.A 53-year-old male with a remote history of colon adenocarcinoma presented with weakness, severe anaemia and an actively bleeding ulcerated lesion in the stomach. An 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed FDG-avid masses in the stomach and mesentery, which were biopsied to reveal an unsuspected diagnosis of plasmacytoma. The original colon tumour pathology was identical and this prompted its re-evaluation to a primary colon plasmacytoma. The patient was treated with chemotherapy and a follow-up PET/CT scan showed complete resolution of the gastric and mesenteric masses. 18F-FDG PET/CT is useful in the restaging and follow-up of this very rare extramedullary plasmacytoma.

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“…In the clinical setting of patients with 'burned-out' germ cell tumors, metastatic lesions are first identified in the presence of regressed primary tumors, the latter diagnosed by a distinct histological appearance [7,8]. However, our case report differs in demonstrating a clear aggressive behavior for the primary tumor upon clinical manifestation post-metastatectomy, with radiological growth from undetectable to an 11 cm lesion over four months, which is inconsistent with a 'burned-out' primary.…”

Section: Discussionmentioning

confidence: 99%

'Prechronous' metastasis in clear cell renal cell carcinoma: a case report

et al. 2011

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IntroductionAlthough metastatic carcinoma in the presence of an occult primary tumor is well recognized, underlying reasons for the failure of the primary tumor to manifest are uncertain. Explanations for this phenomenon have ranged from spontaneous regression of the primary tumor to early metastasis of the primary tumor before manifestation of a less aggressive primary tumor. We report a case of 'prechronous' metastasis arising from clear cell renal cell carcinoma, where metastatic disease initially manifested in the absence of a primary renal tumor, followed by aggressive growth of the primary renal lesion.Case presentationA 43-year-old Malay man initially presented to our facility with fever and cough. He subsequently underwent surgical resection of a 9 cm right-sided lung mass found on radiological examination. Histology showed a high-grade clear cell tumor with sarcomatoid differentiation, suggestive of a metastasis from clear cell renal cell carcinoma. However, no concurrent renal lesions were noted on computed tomographic evaluation at that time. Then, four months after lung resection, he presented with a subcutaneous mass in the left loin, as well as right loin discomfort. Computed tomography scanning revealed a 10 cm right renal mass, with renal vein and inferior vena cava invasion, as well as recurrent disease in the right thorax. Histological examination of the excised subcutaneous mass revealed a high-grade carcinoma consistent with clear cell renal cell carcinoma.ConclusionsThis is the first reported case of prechronous metastasis of renal cell carcinoma, with metastatic disease manifesting prior to the development of the primary lesion. The underlying mechanism is uncertain, but our patient's case provides anecdotal support for the early dissemination model of metastasis.

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“Burned out” testicular seminoma presenting as a primary gastric malignancy

Cited by 11 publications

References 23 publications

Burned-Out Testis Tumors in Asymptomatic Infertile Men: Multiparametric Sonography and MRI Findings

Burned-Out Testis Tumors in Asymptomatic Infertile Men: Multiparametric Sonography and MRI Findings

Gastric recurrence of a primary colon plasmacytoma: staging and evaluating response to therapy with 18F-FDG PET/CT

'Prechronous' metastasis in clear cell renal cell carcinoma: a case report

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