Tumor Diagnosis by Genetic Markers Protein P-53, p16, C-MYC, N-MYC, Protein K-Ras, and Gene Her-2 Neu is this possible? Tumor Diagnosis by Genetic Markers C-MYC, N-MYC, Protein P-53, p16

Al-hassany, Hany A.; Albu-Rghaif, Ali H.; Naji, Meena Akeel

doi:10.53350/pjmhs211582350

Cited by 22 publications

(6 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Kebede et al reported that half of NSIs occurred in women [25]. There was a significant relationship between the gender and needle stick injuries (p = <0.001) that was in line with the study of Pili et al [26], [27].…”

Section: Prevalence Of Nsis Among Hcwssupporting

confidence: 75%

Knowledge, Attitude, and Practice Regarding Needle Stick Injuries Among Health Care Workers in Baghdad Teaching Hospital and Ghazy Al-Hariri Hospital for Surgical Specialties in 2020

Al-Khalidi

Nasir

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Background: Needle stick injuries are serious occupational hazards in the transmission of a variety of bloodborne diseases, more than twenty pathogens can be transmitted through NSI including hepatitis B virus, hepatitis C virus, and human immunodeficiency virus (AIDS) among healthcare workers. Objectives: Assess the knowledge, attitude and practice of health care workers towards needle stick injuries. Determine the prevalence of needle stick injuries among healthcare workers and its predisposing factors. Methods: Cross-sectional descriptive study, a convenient sample of 260 health care workers was selected from Baghdad Teaching hospital and Ghazy Al Hariri hospital in Baghdad, Iraq. Data were collected by an anonymous questionnaire from January to June 2020. The collected data were analyzed by using statistical package for the social sciences (SPSS version 23). Results Prevalence of NSIs among HCWs was found to be 53.8%, which was higher in nurses (29.3%) and laboratory technicians (28.5%) followed by surgeon doctors (15.7%), assistant surgeons (13.6%) and dentists (12.9%) .The highest number of needle stick injuries occurred by recapping of needles (41.4%) followed by during drug administration (27.9%), from hand to hand (10.7%) and during blood drawing (7.9%). A proportion of (64.5%) of health care workers whom sustained needle stick injury had reported their Injury. Doctors scored better than others regarding mean scores of knowledge, attitude and practice. There was a highly significant association among knowledge, attitude and practice scores of the HCWs (P<0.001). A considerable percentage of the participants (80.2%) were completely immunized against HBV. Conclusions: The study showed a high prevalence of NSIs among health care workers. The score of knowledge was high, moreover acceptable responses were obtained in most attitude and practice statements, except for recapping of needles statements.

show abstract

Section: Prevalence Of Nsis Among Hcwssupporting

confidence: 75%

Knowledge, Attitude, and Practice Regarding Needle Stick Injuries Among Health Care Workers in Baghdad Teaching Hospital and Ghazy Al-Hariri Hospital for Surgical Specialties in 2020

Al-Khalidi

Nasir

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…The Current work is a preliminary trial for the selection of pharmacological molecules with inhibitory potential of the normal and mutated androgen receptor (T877A). 11 – 19 …”

Section: Methodsmentioning

confidence: 99%

In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer

2022

View full text Add to dashboard Cite

Background: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases. Despite advances in treatment against prostate cancer, it can become resistant to drugs. Therefore, the aim of current study was to search and identify binding sites for the repositioning of drugs by computational methods (docking). Methods: Based on the protein structure of the wild androgen receptor, the analysis parameters (22x22x22 on the X, Y, and Z axes) were established. Results: The interactions of the natural ligands with androgen receptor were 10.0 (testosterone) and 10.8 (dihydrotestosterone) while mutated androgen receptor (T877A) had a low affinity with testosterone and dihydrotestosterone (-5.3 and -6.7, respectively). In the interactions of both receptors with the reported inhibitors (antagonists), a decrease with Bicalutamide (-8.3 and -4.3, respectively) and an increase in affinity with Flutamide and Nilutamide (-7.7 and 8.6, wild AR; -8.7 and -9.3 AR T877A) were observed. As for Enzalutamide and Apalutamide (second-generation antagonists), the change was minimal between wild androgen receptor and T877A (-7.6 and -7.7; -7.3 and -7.3, respectively). The change in the affinity of the ligands with androgen receptor and androgen receptor T877A shows how a mutation alters the bonds between these molecules. Conclusion: The identification of key sites and potent inhibitors against abnormal androgen receptor functions will enrich prostate cancer treatments.

show abstract

“…During the COVID-19 pandemic, neuromuscular complications were evident [ 25 ]. Between 30% and 50% of the ICU patients presented generalized neuromuscular weakness during their hospitalization that appears to be secondary to CIM and CIP or their combination, causing prolongation and increasing admission time and ventilation duration in the ICU [ 25 , 26 ].…”

Section: Literature Reviewmentioning

confidence: 99%

The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention

et al. 2022

View full text Add to dashboard Cite

Myopathy is a disease characterized by muscle dysfunction in general and may be associated with genetics, medication such as statins, or inflammation. In 2019, an epidemic viral infection (SARS-CoV-2 virus) that invaded most countries worldwide appeared and caused acute respiratory disease. Consequently, patients had to take a group of drugs for a relatively long treatment period. According to several studies, there was an increase in the cases of muscular disorders due to several factors. This study aimed to (1) investigate the relationship between COVID-19 and myopathy and (2) identify the causes and prevention methods. A systematic review was conducted, analyzing several articles from the following databases: ResearchGate, Medline, DOAJ (The Directory of Open-Access Journals), PubMed, and Google Scholar. After performing the search and filtering the results, we included 61 articles. There was a strong relationship between COVID-19 and myopathy, especially in patients admitted to the ICU department, due to medication or neurological dysregulation with multiorgan dysfunctions such as polyneuropathy, peripheral nerve involvement, dysautonomia, Guillain-Barré syndrome, and many others.

show abstract

Tumor Diagnosis by Genetic Markers Protein P-53, p16, C-MYC, N-MYC, Protein K-Ras, and Gene Her-2 Neu is this possible? Tumor Diagnosis by Genetic Markers C-MYC, N-MYC, Protein P-53, p16

Cited by 22 publications

References 37 publications

Knowledge, Attitude, and Practice Regarding Needle Stick Injuries Among Health Care Workers in Baghdad Teaching Hospital and Ghazy Al-Hariri Hospital for Surgical Specialties in 2020

Knowledge, Attitude, and Practice Regarding Needle Stick Injuries Among Health Care Workers in Baghdad Teaching Hospital and Ghazy Al-Hariri Hospital for Surgical Specialties in 2020

In silico comparison between the mutated and wild-type androgen receptors and their influence on the selection of optimum androgenic receptor blockers for the treatment of prostate cancer

The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention

Contact Info

Product

Resources

About