The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention

Awad, Manal A.; Al-Hussaniy, Hany Akeel; Alburghaif, Ali Hikmat; Tawfeeq, Karam Turath

doi:10.25122/jml-2022-0167

Cited by 20 publications

(10 citation statements)

References 43 publications

(61 reference statements)

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“… 1 COVID-19 has the characteristics of strong infectivity, rapid transmission, and general susceptibility among people. 2 Since the outbreak of COVID-19, it has evolved and mutated in the process of transmission, and has formed multiple variants including Alpha, Beta, Gamma, Delta and Omicron. 3 South Africa first detected a COVID-19 variant (B.1.1.529) from case samples, and the World Health Organization named it Omicron variant on 25th November 2021.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics Profile of COVID-19 Patients with Omicron Variant Admitted in a Tertiary Hospital, Central China

Miao¹,

Ren²,

Ren³

2023

IJGM

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Purpose Omicron, a variant of COVID-19, is becoming a major issue of global concern. Its high transmissibility may bring challenges to the distribution of health care in a large population country like China. Investigating the behavior of the virus in the Chinese population will certainly help to plan for the upcoming surge of Omicron. Therefore, we made a preliminary analysis of the clinical and epidemiological characteristics of suspected cases of Omicron at the early stage of the surge. Patients and Methods The study was conducted in Nanyang Central Hospital, a tertiary hospital, from 21st December, 2022 to 8th January, 2023. A total of 210 patients underwent demographic characteristics and clinical symptom collection from their medical records. Moreover, sputum culture was also conducted to explore the types of bacterial or fungal infections. Results Our results showed that 5 patients (4.1%) were aged 16–49, 40 patients (32.5%) were aged 50–70, and 78 patients (63.4%) were aged 70 or more in the severe group. The proportion of male patients with severe diseases infected with Omicron is higher than that of female patients and the proportion of severe cases increases with age. The main symptoms of patients infected with Omicron are cough (91, 74.0%), fever (90, 73.2%), and asthma (73, 59.3%). The pathogens Streptococcus pneumoniae (71, 31.0%), Staphylococcus aureus (46, 20.1%), Mycoplasma pneumoniae (26, 11.4%), Klebsiella pneumoniae (18, 7.9%), Acinetobacter baumannii (13, 5.7%), and Haemophilus influenzae were detected in lower respiratory tract. Conclusion This study suggests that age >70 is a risk factor for severe COVID-19 and that patients often have bacterial or fungal infections. Our research results may help to provide effective treatment for patients with Omicron infection and also contribute to health economic analysis and research to assist future public health decision-making.

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Section: Introductionmentioning

confidence: 99%

Clinical Characteristics Profile of COVID-19 Patients with Omicron Variant Admitted in a Tertiary Hospital, Central China

Miao¹,

Ren²,

Ren³

2023

IJGM

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“…Group III: Rats were fed a high-fat diet for 8 weeks and received 500 mg/kg [ 22 ] of Hibiscus tiliaceus leaf extract.…”

Section: Methodsmentioning

confidence: 99%

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Mohammed,

Mutlag

2023

JMedLife

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Obesity is a world health concern and a serious risk factor for several chronic diseases. Hibiscus tiliaceus is a plant with reported anti-obesity properties. However, the preclinical anti-obesity effect of ethanolic extract of Iraqi Hibiscus tiliaceus has not been studied yet. This study aimed to evaluate the preclinical anti-obesity properties of Iraqi Hibiscus tiliaceus extract, alone or in combination with orlistat, on high-fat diet-induced obesity in male rats. Male rats were divided into five groups: control, induction, ethanolic extract of Iraqi Hibiscus tiliaceus (250 mg/kg and 500 mg/kg), orlistat (Xenical) alone (10 mg/kg), and a combination of the extract (250 mg/kg) with Xenical. The rats were fed a high-fat diet to induce obesity, and treatments were given orally for 8 weeks. Body weight, food intake, serum lipid profile, and liver enzymes were measured. Administration of ethanolic extract of Iraqi Hibiscus tiliaceus (250 mg/kg and 500 mg/kg), Xenical alone (10 mg/kg), and combination with the extract (250 mg/kg) for 8 weeks significantly reduced body weight, food intake, serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and liver enzymes (aspartate transaminase and alanine transaminase) when compared to the induction group. The ethanolic extract of Iraqi Hibiscus tiliaceus showed anti-obesity effects and could be a potential therapeutic agent in managing obesity. However, further studies are needed to evaluate its clinical efficacy and safety.

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“…Myopathy/rhabdomyolysis is a disorder characterized by muscle dysfunction that could be linked to genetics, inflammation, or a serious side effect of medications such as statins. 27 The auxiliary examination methods for diagnosis of muscle injury including B-mode ultrasound, magnetic resonance imaging, and creatine kinase (CK) examination. Clinical features of different statin-associated muscle symptoms including myalgia, myopathy, myositis, myonecrosis, and rhabdomyolysis, are complex.…”

Section: Muscle Injury Caused By Statinsmentioning

confidence: 99%

Statin-Associated Liver Dysfunction and Muscle Injury: epidemiology, Mechanisms, and Management Strategies

Ma,

Xu,

Sun

et al. 2024

IJGM

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Surveillance of drug safety is an important aspect in the routine medical care. Adverse events caused by real-world drug utilization has become one of the leading causes of death and an urgent issue in the field of toxicology. Cardiovascular disease is now the leading cause of fatal diseases in most countries, especially in the elderly population who often suffer from multiple diseases and need long-term multidrug therapy. Among which, statins have been widely used to lower bad cholesterol and regress coronary plaque mainly in patients with hyperlipidemia and atherosclerotic cardiovascular diseases (ASCVD). Although the real-world benefits of statins are significant, different degrees and types of adverse drug reactions (ADR) such as liver dysfunction and muscle injury, have a great impact on the original treatment regimens as well as the quality of life. This review describes the epidemiology, mechanisms, early identification and post-intervention of statin-associated liver dysfunction and muscle injury based on the updated clinical evidence. It provides systematic and comprehensive guidance and necessary supplement for the clinical safety of statin use in cardiovascular diseases.

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The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention

Cited by 20 publications

References 43 publications

Clinical Characteristics Profile of COVID-19 Patients with Omicron Variant Admitted in a Tertiary Hospital, Central China

Clinical Characteristics Profile of COVID-19 Patients with Omicron Variant Admitted in a Tertiary Hospital, Central China

Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats

Statin-Associated Liver Dysfunction and Muscle Injury: epidemiology, Mechanisms, and Management Strategies

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