Tumor Development in Mice Bearing a Plastic Cylinder and Inoculated With Human Neoplastic Cells
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Pasqualini, Christiane Dosne; Sen, Luisa; Saal, F; Schwartz, Laura; Tkaczevski, Lidia Z.

doi:10.1093/jnci/51.1.283

Cited by 9 publications

(2 citation statements)

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“…PX Fibrosarcoma which was induced by a foreign body (glass cylinder) 6 months after s.c. implantation in a BALB/c female, as described previously (Pasqualini et al, 1973 Cold-treated cells Tumour cells (2 x 106) which had been maintained at -1 5°C for 45min were inoculated s.c. 21 and 7 days before tumour challenge.…”

Section: Tumoursmentioning

confidence: 99%

“Concomitant immunity” in murine tumours of non-detectable immunogenicity

Ruggiero¹,

Bustuoabad²,

Bonfil³

et al. 1985

Br J Cancer

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Summary Various immunization assays were used to demonstrate the lack of immunogenicity of three BALB/c tumours of spontaneous origin and of a fourth one resulting from foreign body tumorigenesis. All four tumours inhibited the growth of a second implant of the same tumour into the contralateral flank. In our tumour models "concomitant immunity" (1) was not mediated by macrophage or T-cell dependent immune reactions: both thymectomized BALB/c and nude mice (treated or untreated with silica) gave the same results as intact mice; (2) showed some degree of non-specificity, inhibiting the growth of a different tumour in 3/4 cases; though, the existence of a specific component could not be discarded; (3) was proportional to the volume of the primary tumour at the time of the second challenge; (4) was dependent on actively growing primary tumour, not being obtained with progressively increasing daily inocula of irradiated tumour cells; (5) was detectable in an actively growing secondary tumour: recurrent growth after partial surgical excision was inhibited and (6) involved cytostasis of the secondary tumour: a syngeneic graft of the overlying skin led to tumour growth while histological studies revealed the presence of viable tumour cells. It is postulated that "concomitant immunity" or resistance can be generated without the active participation of the immune system and that tumour-related factors are, in certain cases, responsible for blocking the growth of secondary tumours.

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Section: Tumoursmentioning

confidence: 99%

“Concomitant immunity” in murine tumours of non-detectable immunogenicity

Ruggiero¹,

Bustuoabad²,

Bonfil³

et al. 1985

Br J Cancer

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“…The introduction of human leukemia/lymphoma cells into the cylinder increased the incidence of fibrosarcoma to 73 %, in a sense confirming our previous results using the intrasplenic model, as mentioned above. Interestingly it was observed that human neoplastic cells in this context are capable of surviving during 72 hours [82].…”

Section: A In Our Laboratory -The Glass Cylinder Modelmentioning

confidence: 98%

Experimental Onco-Immunology Revisited

Pasqualini¹,

Ruggiero²,

Bustuoabad³

et al. 2005

CCTR

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The search for the cause of cancer has led to five successive theories involving viruses, oncogenes, tumor suppressor genes, somatic mutation cascade and inflammation. The latter, without discarding the former theories, is now the prevailing paradigm recognizing that neoplastic cells require participation of the microenvironment for tumor progression. Inflammatory reactions are dependent on an overabundance of immune responses which are both in favor and against tumor development. This homeostatic immunological behavior has led to the concept of tumor immunoediting in an attempt to elucidate why tumors grow. This review is a non-exhaustive description of the different experimental highlights which have led to our present knowledge of cancer. During its 47 years of existence, our laboratory has contributed extensively to the experimental development of onco-immunology, so that our results are described within the background of international discoveries. As for cancer therapy, the many attempts made, both at the experimental and clinical levels, have been mainly frustrating and yet, as oncologists, we are always ready to try again.

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Foreign body carcinogenesis

Moore¹

1991

Cancer

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A recent report' of a malignant fibrous histiocytoma developing 44 years after severe injury and implantation of metallic fragments is pertinent to the general phenomena of foreign body (FB) carcinogenesis. Rarity of this event in human patients in contrast to other species is noteworthy, but has great biologic interest. For example, less than 20 malignancies associated with joint replacements have been reported, and a global registry of FB malignancies has been proposed. FB associated with subsequent site-related malignancies include the following: bullets, steel fragments of various sorts, implanted protheses at fracture sites, metallic sutures, nylon mesh, and various fibers (including asbestos). The organ sites of such malignancies include the soft tissues, bone and bone marrow, lungs, pleural and peritoneal linings, and perhaps other organs such as the urinary bladder, gall bladder, and colon.The predominant diagnosis of such conditions has been sarcoma and related sarcomatous lesions.2 Different FB mechanisms may be related to carcinomas of the lung, breast, and bladder and mesotheliomas.Physical form rather than chemical composition is the critical factor for asbestos carcinogenesis in humans and for the FB malignancies in other species. The predominance of smoking in asbestos-related lung cancer probably results, in part, from the inability of the impaired and replaced ciliated epithelium to expel the fibers. In brief, the rules of Ames for carcinogenic (mutational) chemicals and those of the much maligned (and rightly so) Delaney Clause are not applicable.The first observation of FB carcinogenesis was the serendipitous development of sarcomas at the site of bakelite discs inserted in rats and, subsequently, kidney wrapping with plastic for a study of hypertension. A comprehensive review of early FB research is fascinating.' From the Division of Surgical Oncology, Denver General Hospital Address for rcprints: George E. Moore, MD, PhD, Department of Denver, Colorado. Surgery, Denver General Hospital. Denver. CO 80204.Bland4 and others have reported a series of studies involving the insertion of glass, plastic, and metal sheets in rodents. An important observation was the decrease in carcinogenecity as the surface area of flat, smooth, thin forms was decreased. For example, the fragmentation of cover slips, but insertion of the same amount of material, resulted in a sharp decrease and even absence of malignancies. In one such experiment an implanted sheet of nylon caused sarcomas in 58% of rats, whereas the same amount of powdered nylon caused none. Dr. Bland confirmed major differences in the susceptibility of various mouse strains and hybrids to FB carcinogenesis and the length of precancerous latent period.In other experiments, filters with smaller pores induced more sarcomas than those with larger pores. Smooth surfaces that inhibit cell adherence were far more carcinogenic than rough ones.5 Similar sarcomatous lesions could be elicited much less successfully in other species and in primates.It is aston...

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Tumor Development in Mice Bearing a Plastic Cylinder and Inoculated With Human Neoplastic Cells 2

Cited by 9 publications

References 0 publications

“Concomitant immunity” in murine tumours of non-detectable immunogenicity

“Concomitant immunity” in murine tumours of non-detectable immunogenicity

Experimental Onco-Immunology Revisited

Foreign body carcinogenesis

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