Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis

Wang, Jialin; Du, Xin; Wang, Xiao; Xiao, Huixiang; Jing, Nan; Xue, Wei; Dong, Baijun; Gao, Wei‐Qiang; Fang, Yuxiang

doi:10.1016/j.canlet.2021.11.017

Cited by 28 publications

(22 citation statements)

References 44 publications

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“…Wnt/β-catenin pathway [95] miR-106a miR-106a/TP53INP1 [96] miR-139-5p miR-139-5p/Notch 1 [97] miR-17-5p PTEN/PI3K/Akt [98] miR-365 NKX2-1/EGFR/PI3K [99] miR-192-5p miR-192-5p/ TRIM-44 [100] miR-886-3p miR-886-3p-PLK1/TGF-β1 pathway [101] DNA methylation DNMTs miR-886-3p-PLK1/TGF-β1 pathway [101] DNMTs WIF-1 [102] Prostate cancer ncRNA lncRNA NEAT1 CYCLINL1/CDK19/ NEAT1-1 [103] miR-940 miR-940/ARHGAP1 and FAM134A [104] miR-181b-5p miR-181b-5p/ Oncostatin M axis [105] lncRNA HOXA11-AS HOXB13/lncRNA HOXA11-AS/ IBSP [106] lncRNA PCAT6 PCAT6/IGF2BP2/IGF1R axis [107] lncRNA NEAT1 miR-205-5p/RUNX2/ SFPQ/PTBP2 axis [108] miR-378a-3p miR-378a-3p/ Dyrk1a/ Nfatc1/Angptl2 [109] Deciphering and Targeting Epigenetics in Cancer Metastasis DOI: http://dx.doi.org/10.5772/intechopen.106584…”

Section: Cancer Types Epigenetic Types Biomarkers Pathways Referencesmentioning

confidence: 99%

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Deciphering and Targeting Epigenetics in Cancer Metastasis

Huang¹,

Lu²,

Liang³

2023

Cancer Metastasis - Molecular Mechanism and Clinical Therapy

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Once cancer metastasizes to distant organs like the bone, liver, lung, and brain, it is in an advanced stage. Metastasis is a major contributor to cancer-associated deaths. Countless molecules and complex pathways are involved in the dissemination and colonization of cancer cells from a primary tumor at metastatic sites. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. Emerging evidence suggested a variety of epigenetic regulations were identified to regulate cancer metastasis. Here we summarize the procedures and routes of cancer metastasis as well as the roles of epigenetics including ncRNA, DNA methylation, and histone modifications in common metastases. Then we further discuss the potentials and limitations of epigenetics-related target molecules in diagnosis, therapy, and prognosis.

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Section: Cancer Types Epigenetic Types Biomarkers Pathways Referencesmentioning

confidence: 99%

“…lncRNA PCAT6 enhances prostate cancer bone metastasis and tumor growth by upregulating IGF1R expression via increasing IGF1R mRNA stability through the PCAT6/IGF2BP2/IGF1R pathway [107]. lncRNA NEAT1/miR-205-5p/ RUNX2/SFPQ/PTBP2 axis and miR-378a-3p/ Dyrk1a/Nfatc1/Angptl2 axis are also devoted to bone metastasis [108,109].…”

Section: Prostate Cancermentioning

confidence: 99%

Deciphering and Targeting Epigenetics in Cancer Metastasis

Huang¹,

Lu²,

Liang³

2023

Cancer Metastasis - Molecular Mechanism and Clinical Therapy

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“…Surely, not only on lncRNAs, but also hnRNPA2/B1 could act on miR-122-5p EXO-motif to induce hepatic metastasis of lung cancer [ 119 ], and similarly could motivate exo-miR-394-mediated M2 polarization of macrophages [ 120 ]. Moreover, tumor-derived EVs-miR-378a-3p was enriched by hnRNPA2/B1 overexpression as well [ 121 ].…”

Section: The Roles Of Hnrnpa/b In Cancers: Molecular Mechanisms and C...mentioning

confidence: 99%

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Wang

et al. 2022

Cell Death Discov.

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Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 and A3, which share the similar structure and functions. With the advance in understanding the molecular biology of hnRNPA/B, it has been gradually revealed that hnRNPA/B plays a critical role in almost the entire steps of RNA life cycle and its aberrant expression and mutation have important effects on the occurrence and progression of various cancers. This review focuses on the clinical significance of hnRNPA/B in various cancers and systematically summarizes its biological function and molecular mechanisms.

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“…Various studies have shown the functions and mechanisms of exosomal ncRNAs in the bone metastasis of PCa. A study has shown that PCa cell-derived miR-378-3p containing EVs promotes osteolytic progression in the bone metastasis of PCa by activating the DYRK1A/NFATC1/ANGPTL2 axis in the macrophages of bone marrow [ 54 ]. Ma et al have shown that PCa-derived small EVs (sEVs) containing miR152-3p transmit osteolytic signals to osteoclasts and promote osteolytic progression in bone metastasis by directly targeting the osteoclastogenesis regulator MAFB [ 55 ].…”

Section: Emerging Functions Of Ev-derived Ncrnas In Organ-specific Me...mentioning

confidence: 99%

Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications

Jiang

Tan

Zhang

et al. 2022

Cancers

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Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs). Metastasis is a major cause of cancer-related death. Most cancer cells disseminate and colonize a specific target organ via EVs, a process known as “organ-specific metastasis”. Mounting evidence has shown that EVs are enriched with ncRNAs, and various EV-ncRNAs derived from tumor cells influence organ-specific metastasis via different mechanisms. Due to the tissue-specific expression of EV-ncRNAs, they could be used as potential biomarkers and therapeutic targets for the treatment of tumor metastasis in various types of cancer. In this review, we have discussed the underlying mechanisms of EV-delivered ncRNAs in the most common organ-specific metastases of liver, bone, lung, brain, and lymph nodes. Moreover, we summarize the potential clinical applications of EV-ncRNAs in organ-specific metastasis to fill the gap between benches and bedsides.

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Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis

Cited by 28 publications

References 44 publications

Deciphering and Targeting Epigenetics in Cancer Metastasis

Deciphering and Targeting Epigenetics in Cancer Metastasis

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications

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