Tumor-augmenting Effect of Histone Methyltransferase WHSC1 on Colorectal Cancer Via Epigenetic Upregulation of TACC3 and PI3K/Akt Activation

Fan, Yuejuan; Zhou, Lei; Pan, Lizhen

doi:10.1016/j.arcmed.2022.10.006

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…19 Additional literature reported that TACC3 was activated by WHSC1 to regulate the occurrence of PI3K and AKT pathway phosphorylation, and promote EMT in colorectal cancer and then play a pro-metastatic role. 31 The current study showed that inhibition of TACC3 suppressed Wnt/β-Catenin and PI3K/AKT signaling pathways in HCC tissues, which regulated cancer stem cell characteristics. 32 The data presented in this study showed that both TACC3, p-PI3K and p-AKT protein levels were notably decreased in HCC cells after transfection with si-FAM111B, indicating that FAM111B silencing could inhibit TACC3/PI3K/AKT signaling pathway activation in HCC.…”

Section: Discussionmentioning

confidence: 61%

“…Ha et al revealed that TACC3 was an inducer of EMT and promoted EMT progression by activating the PI3K/AKT signaling pathway 19 . Additional literature reported that TACC3 was activated by WHSC1 to regulate the occurrence of PI3K and AKT pathway phosphorylation, and promote EMT in colorectal cancer and then play a pro‐metastatic role 31 . The current study showed that inhibition of TACC3 suppressed Wnt/β‐Catenin and PI3K/AKT signaling pathways in HCC tissues, which regulated cancer stem cell characteristics 32 .…”

Section: Discussionmentioning

confidence: 99%

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Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled‐coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma

Yang,

Yan,

Jiao

et al. 2023

Environmental Toxicology

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As a complex systemic disease, primary liver cancer ranks third in death rate for solid tumors worldwide. Family with sequence similarity 111 member B (FAM111B), which was found to be aberrantly mutated in multiple cancers, is a candidate oncogene. We aimed to determine the function and mechanism of FAM111B in hepatocellular carcinoma (HCC). The expression of FAM111B was evaluated in HCC tissues, adjacent tissues, HCC cell lines. The impact of FAM111B on proliferation, invasion, apoptosis and EMT of HCC cells were detected by CCK‐8, Transwell, flow cytometry and Western blot assays. The relationship between FAM111B and transforming acidic coiled‐coil protein 3 (TACC3) was assessed by CoIP and Immunofluorescence (IF) staining assays. The effect of FAM111B on tumor growth was detected by using xenograft model of nude mice. The expression of FAM111B was upregulated in HCC tissues and cell lines, and the prognosis of HCC patients was worse in the high FAM111B expression group, and its expression level was associated with the TNM stage of HCC. FAM111B silencing inhibited HCC cell proliferation and invasion, EMT and induced apoptosis. Besides, TACC3 served as an interactor for FAM111B, which could enhance TACC3 expression, thus activing PI3K/AKT pathway. Rescue experiments revealed that elevated of TACC3 restored the inhibitory effect of FAM111B overexpression on the cell functions via PI3K/AKT pathway. In vivo, FAM111B inhibition hampered tumor growth and metastasis of HCC. This study highlighted a key player of FAM111B in modulating the malignant biological progression of HCC via TACC3/PI3K/AKT signaling pathway, displaying a potential therapeutic target for HCC.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled‐coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma

Yang,

Yan,

Jiao

et al. 2023

Environmental Toxicology

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“…WHSC1 is found to promote the activation of transforming acidic coiled‐coil containing protein 3, the expression of which can upregulate phosphatidylinositol‐3‐kinase (PI3K)/Akt signaling and induce EMT process. 75 In addition, histone methyltransferase SET and MYND domain containing 2 (SMYD2) epigenetically modulates SMAD3 expression and the knockdown of SMYD2 attenuates the process of EMT. 76 Histone deacetylase (HDAC) is one of the main players of histone acetylation.…”

Section: Transcriptional Regulation Of Empmentioning

confidence: 99%

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.

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The role of dietary Clostridium autoethanogenum protein in the growth, disease resistance, intestinal health and transcriptome response of Pacific white shrimp under different stocking densities

Yuan,

Xie,

Chen

et al. 2024

Aquaculture

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Tumor-augmenting Effect of Histone Methyltransferase WHSC1 on Colorectal Cancer Via Epigenetic Upregulation of TACC3 and PI3K/Akt Activation

Cited by 4 publications

References 27 publications

Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled‐coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma

Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled‐coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

The role of dietary Clostridium autoethanogenum protein in the growth, disease resistance, intestinal health and transcriptome response of Pacific white shrimp under different stocking densities

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