Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets
Xiangpeng Wang,
Xiaoxia Xue,
Mingshi Pang
et al.
Abstract:Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via… Show more
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