Tumor-Associated Microbiota in Esophageal Squamous Cell Carcinoma

Yang, Weixiong; Chen, Chang‐Han; Jia, Minghan; Xing, Xin; Gao, Lu; Tsai, Huei‐Ting; Zhang, Zhanfei; Liu, Zhenguo; Zeng, Bo; Yeung, Sai‐Ching Jim; Lee, Mong‐Hong; Chen, Cheng

doi:10.2139/ssrn.3699571

Cited by 7 publications

(15 citation statements)

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“…Indeed, higher levels of toxigenic Bacteroides fragilis strains have been reported in secretory diarrhea and various types of cancer including colorectal cancer, prostate cancer [19,20]. It seems to be inconsistency between our study and previous reports when Cheng et al have demonstrated signi cantly enriched Bacteroides in ESC [13]. However, this discrepancy might be explained by samples isolated from different sites and diverse diets of the individuals recruited.…”

Section: Discussioncontrasting

confidence: 93%

“…In the present study, we pro led the structure of esophageal microbiota in ES, ESCC patients and matched control through 16S rRNA gene sequencing and predicted the functional changes. We found a lower microbial diversity in ESCC than in healthy controls, which were supported by previous ndings [12], whereas other studies indicated a decreasing tendency or a higher diversity without signi cant difference [13][14][15]. Although studies conducted by Geng et al and Natalia et al [12,16]suggested decreased richness of microbiota in ESCC patients, our study observed a contrary trend.…”

Section: Discussionsupporting

confidence: 88%

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Characterization of the Esophageal Microbiota in Patients with Esophagitis and Esophageal Squamous Cell Carcinoma

zongdan¹,

Wang

shen³

et al. 2021

Preprint

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Background: Microbial imbalances have been well elucidated in esophageal adenocarcinoma, but few studies addressing the microbiota in esophageal squamous cell carcinoma (ESCC) and esophagitis (ES). We aimed to explore the associations of esophageal microbiota with these patients.Results: A total of 68 individuals were enrolled (control = 21, ES=15, ESCC = 32). Microbial diversity was significant different between ESCC patients and healthy controls by Chao1 index, Shannon index and PLS-DA. Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria and Fusobacteria were the five dominant bacterial phyla among three groups. Megamonas, Collinsella, Roseburia and Ruminococcus_2 showed a significantly continuous decreasing trend from Normal to ESCC at the genus level. When compared with control group, decreased Fusobacteria at phylum level and Faecalibacterium, Bacteroides, Curvibacter and Blautia at genus level were detected. ESCC samples also displayed a striking reduction of Bacteroidetes, Faecalibacterium, Bacteroides and Blautia in comparison with ES patients. LEfSe analysis indicated a greater abundance of Streptococcus, Actinobacillus, Peptostreptococcus, Fusobacterium, Prevotella in ESCC groups.Conclusions: Our study suggests a potential association between esophageal microbiome dysbiosis and ESCC and provides insights on a potential screening marker for esophageal cancer.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Characterization of the Esophageal Microbiota in Patients with Esophagitis and Esophageal Squamous Cell Carcinoma

zongdan¹,

Wang

shen³

et al. 2021

Preprint

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“…The esophageal squamous cell carcinoma-inducing oral bacteria P. melaninogenica and V. dispar [27] were coenriched in the Y-thick greasy group. Multifunctional P. melaninogenica in saliva is also associated with oral squamous cell carcinoma [28] and is causative of periodontitis [29], Alzheimer's disease mortality [30], hyperglycemia [31], [and MHCII, CD80 and IFN-γ upregulation in salivary gland epithelial cells in Sjögren's syndrome [32].…”

Section: Disease-related Characteristic Bacteria In Specific Tongue Coating Typesmentioning

confidence: 99%

Microbial characteristics across different tongue coating types in a healthy population

Chen

et al. 2021

Journal of Oral Microbiology

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BackgroundThe physical appearance of tongue coatings is vital for traditional Chinese medicine (TCM) to diagnose health and disease status. The microbiota of different tongue coatings could also influence coating formation and be further associated with specific diseases. Previous studies have focused on bacteria from different tongue coatings in the context of specific diseases, but the normal variations in healthy individuals remain unknown. Aim: We examined the tongue microbiota by metagenomics in 94 healthy individuals classified into eight different tongue types. Results: The overall composition of the tongue coating microbiome is not drastically different among different coating types, similar to the findings of previous studies in healthy populations. Further analysis revealed microbiota characteristics of each coating type, and many of the key bacteria are reported to be implicated in diseases. Moreover, further inclusion of diabetic patients revealed disease-specific enrichment of Capnocytophaga, even though the same tongue coatings were studied. Conclusions: This work revealed the characteristic compositions of distinctive tongue coatings in a healthy population, which serves as a basis for understanding the tongue coating formation mechanism and provides a valuable reference to further investigate diseasespecific tongue coating bacterial markers.

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“…Only a small number of studies characterized the human esophageal microbiota in health and disease [ 152 , 153 , 154 ]. A recent study demonstrated significant enrichments of Treponema amylovorum, Streptococcus infantis, Prevotella nigrescens, Porphyromonas endodontalis, Veillonella dispar, Aggregatibacter segnis, Prevotella melaninogenica, Prevotella intermedia, Prevotella tannerae, Prevotella nanceiensis and Streptococcus anginosus in ESCC [ 155 ]. These 10 bacterial strains are involved in oral health, suggesting that oral hygiene plays important roles in tumor development of ESCC [ 155 ].…”

Section: New Diagnostic Approaches Using Microbial Markersmentioning

confidence: 99%

“…A recent study demonstrated significant enrichments of Treponema amylovorum, Streptococcus infantis, Prevotella nigrescens, Porphyromonas endodontalis, Veillonella dispar, Aggregatibacter segnis, Prevotella melaninogenica, Prevotella intermedia, Prevotella tannerae, Prevotella nanceiensis and Streptococcus anginosus in ESCC [ 155 ]. These 10 bacterial strains are involved in oral health, suggesting that oral hygiene plays important roles in tumor development of ESCC [ 155 ]. Consistent with these data, it was demonstrated that tooth losses can potentially increase the risk of ESCC development [ 156 ] and that ESCC with high burden of F. nucleatum , which inhabits the oral cavity and causes periodontal disease, correlates with poor recurrence‐free survival (RFS) [ 157 ].…”

Section: New Diagnostic Approaches Using Microbial Markersmentioning

confidence: 99%

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

Lee

2021

Cancer Communications

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It has been shown that gut microbiota dysbiosis leads to physiological changes and links to a number of diseases, including cancers. Thus, many cancer categories and treatment regimens should be investigated in the context of the microbiome. Owing to the availability of metagenome sequencing and multiomics studies, analyses of species characterization, host genetic changes, and metabolic profile of gut microbiota have become feasible, which has facilitated an exponential knowledge gain about microbiota composition, taxonomic alterations, and host interactions during tumorigenesis. However, the complexity of the gut microbiota, with a plethora of uncharacterized host‐microbe, microbe‐microbe, and environmental interactions, still contributes to the challenge of advancing our knowledge of the microbiota‐cancer interactions. These interactions manifest in signaling relay, metabolism, immunity, tumor development, genetic instability, sensitivity to cancer chemotherapy and immunotherapy. This review summarizes current studies/molecular mechanisms regarding the association between the gut microbiota and the development of cancers, which provides insights into the therapeutic strategies that could be harnessed for cancer diagnosis, treatment, or prevention.

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Tumor-Associated Microbiota in Esophageal Squamous Cell Carcinoma

Cited by 7 publications

References 0 publications

Characterization of the Esophageal Microbiota in Patients with Esophagitis and Esophageal Squamous Cell Carcinoma

Characterization of the Esophageal Microbiota in Patients with Esophagitis and Esophageal Squamous Cell Carcinoma

Microbial characteristics across different tongue coating types in a healthy population

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

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