Tumor‐associated immunogolobulins. The elution of IgG2 from mouse tumors

Ran, Maya; Witz, Isaac P.

doi:10.1002/ijc.2910060306

Cited by 44 publications

(16 citation statements)

References 16 publications

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“…Accelerated tumor growth has been shown by low PH specific tumor eluates in place of antiserum, with MCA and benzopyrene-induced sarcomas (Witz et al, 1967;Ran and Witz, 1970;Witz, 1971; Ran and Witz, 1972) and with rat polyomas (Bansal et al, 1972). In all the papers cited, the recipients were immunologically competent and the effect was ascribed by the authors to enhancement (blockage of tumor cell antigens or lymphoid effector cells) by specific antibodies or immune complexes.…”

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confidence: 91%

Stimulation of transplanted 3‐methylcholanthrene‐induced sarcomas in mice by specific immune and by normal serum

Biddle

1976

Intl Journal of Cancer

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Serum from Bl x C3H mice carrying syngeneic, progressively growing, highly immunogenic 3-methylcholanthrene-induced tumors when admixed with the specific tumor and inoculated into immunologically crippled syngeneic recipients, stimulated growth as compared with serum from control normal mice. It appears that this acceleration of tumor growth is an immune effect since it is not present when a non-immunogenic (spontaneous tissue culture) tumor is used; and the active factor can be absorbed from the serum by the specific tumor but not by an immunologically unrelated tumor. Normal serum per se also stimulated tumor growth, but to a smaller extent.

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confidence: 91%

Stimulation of transplanted 3‐methylcholanthrene‐induced sarcomas in mice by specific immune and by normal serum

Biddle

1976

Intl Journal of Cancer

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“…Lymph-node cells and circulating lymphocytes from tumor-bearing animals and human patients are specifically cytotoxic to cultured tumor cells from the same individuals in vitro (Hellstrom et nl., 1968;Hellstrom and Hellstrom, 1969;Heppner and Pierce, 1969; Bubenik et a/., 1970;Sjogren and Borum, 1971;Hellstrom et al, 1971~). The appearance of a blocking serum activity, probably mediated by antigen-antibody complexes, has been implicated as partially responsible for the progressive tumor growth in individuals having cytotoxic lymphocytes although other escape mechanisms have to be considered as well (Hellstrom and Hellstrom, 1970b;Sjogren et al, 1971).…”

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confidence: 94%

Counteraction of the blocking of cell‐mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats

Bansal

Sjögren

1972

Intl Journal of Cancer

100

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“…Thomson and Alexander (33) described multiple neoantigens with different molecular weights on tumor cell surface. In addition, Ran and Witz (34) and Vanky et al (35) reported that immunoglobulin and/or antibodies were chemically eluted from immunogenic tumor cell surface. In our studies, it is not clear whether this partially overlapping antigenicity demonstrated on xenogenic antisera is caused by immunochemical similarity or by an insoluble surface antigen being tightly locked in as an antigen-antibody complex.…”

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confidence: 99%

Immunological escape mechanism in spontaneously metastasizing mammary tumors.

Kim¹,

Baumler²,

Carruthers³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

115

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Immunological and biochemical studies of spontaneously metastasizing and nonmetastasizing rat mammary carcinomas and, their plasma membranes indicated that: (i) all spontaneously metastasizing tumors have little or no demonstrable glycocalyx, while all nonmetastasizing tumors have a thick glycocalyx; (ii) there is a direct relationship between the glycocalyx and immunogenicity, and an inverse relationship with the metastasizing capacity of tumor cells, properties which can be quantitated by levels of the plasma membrane marker enzyme 5'-nucleotidase (EC 3.1.3.5; 5'-ribonucleotide phosphohydrolase) activity; (iii) the absence of glycocalyx from the metastasizing tumor cell surface seems to result from its dissociation from plasma membranes, for solubilized cell surface antigen is readily found in the'blood of metastasizing tumor bearing rats, while there was no detectable tumor cell surface antigen in the blood of the nonmetastasizing tumor hosts tested; (iv) both metastasizing and nonmetastasizing mammary tumors appear to have a common soluble cell surface' antigen; (v) in addition to this common antigen, there is another membrane-bound antigen in the nonmetastasizing, immunogenic tumor cell surface which presumably is the tuinor specific transplantation antigen; and (vi) this antigen is immunobiologically unique, but seems to be immunochemically related to the common soluble antigen. It is postulated that the lack of an immunogenic coat and/or the presence of solubilized tumor cell surface antigen in the blood may provide an immune escape mechanism for tumor cells by interfering with cell-mediated immune response of tumor hosts, leading to their dissemination.In an earlier report one of us (U.K.) (1) described the induction of spontaneously metastasizing mammary carcinomas (MT) in a highly inbred strain of W/Fu female rats by feeding 3-methylcholanthrene in splenectomized, thymectomized, or both splenectomized and thymectomized hosts, and subsequently subjecting the developing tumors to "immunoselection" in vivo. Such tunmors maintained their metastasizing capacity in normal syngeneic rats generation after transplantation generation, indicating that the metastasizing capacity is an intrinsic property of tumor cells. It was further demonstrated that the metastasizing tumor cells were nonimmunogenic while the ordinary methylcholanthrene-induced nonmetastasizing mammary carcinomas in normal female rats were highly immunogenic, as tested by immunization of the hosts with an equal number of radiation-killed tumor cells, followed by a challenge with a counted number of live tumor cells.In order to study the relationship between tumor cell immunogenicity and metastasizing capacity, two spontaneously metastasizing, non-or weakly-immunogenic mammary carcinomas (SAIT-2A and TMT-50), induced in the manner described above, and a spontaneously metastasizing mammary carcinoma induced with 7,12-dimethylbenz(a)-anthracene in a BCG (bacille Calmette-Guerin) inoculated rat (BCG-MT) were selected. They were matched accord...

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Tumor‐associated immunogolobulins. The elution of IgG2 from mouse tumors

Abstract: In an attempt to detect and characterize immunoglobulins fixed

Cited by 44 publications

References 16 publications

Stimulation of transplanted 3‐methylcholanthrene‐induced sarcomas in mice by specific immune and by normal serum

Stimulation of transplanted 3‐methylcholanthrene‐induced sarcomas in mice by specific immune and by normal serum

Counteraction of the blocking of cell‐mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats

Immunological escape mechanism in spontaneously metastasizing mammary tumors.

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