Tumor-associated autoantibodies in ESCC screening: Detecting prevalent early-stage malignancy or predicting future cancer risk?

Wang, Minmin; Liu, Fangfang; Pan, Yaqi; Xu, Ruiping; Li, Fenglei; Liu, Anxiang; Yang, Haijun; Duan, Liping; Shen, Lin; Wu, Qi; Liu, Ying; Liu, Mengfei; Liu, Zhen; Hu, Zhe; Chen, Huanyu; Cai, Hong; He, Zhonghu; Ke, Yang

doi:10.1016/j.ebiom.2021.103674

Cited by 8 publications

(6 citation statements)

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“…It has been proposed that the clearance rate of tumor markers after treatment may have prognostic significance ( 38 ). If a tumor is completely extirpated by surgery, there is no source of tumor marker production and ideal serum tumor markers, which reflect the total amount of cancer in the body would be negative ( 39 ). Positive postoperative results for serum tumor markers may reflect the presence of occult residual diseases and have potential to bring about subsequent biologic disorders.…”

Section: Discussionmentioning

confidence: 99%

Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma

Huang,

Liu,

et al. 2023

Front. Oncol.

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BackgroundTumor markers are routinely used in clinical practice. However, for resectable patients with esophageal squamous cell carcinoma (ESCC), they are applied infrequently as their prognostic significance is incompletely understood.MethodsThis historical cohort study included 2769 patients with resected ESCC from 2011 to 2018 in a high-risk area in northern China. Their clinical data were extracted from the Electronic Medical Record. Survival analysis of eight common tumor markers was performed with multivariable Cox proportional hazards regressions.ResultsWith a median follow-up of 39.5 months, 901 deaths occurred. Among the eight target markers, elevated postoperative serum SCC (Squamous cell carcinoma antigen) and CEA (Carcinoembryonic antigen) predicted poor overall survival (SCC HRadjusted: 2.67, 95% CI: 1.70-4.17; CEA HRadjusted: 2.36, 95% CI: 1.14-4.86). In contrast, preoperative levels were not significantly associated with survival. Stratified analysis also demonstrated poorer survival in seropositive groups of postoperative SCC and CEA within each TNM stage. The above associations were generally robust using different quantiles of concentrations above the upper limit of the clinical normal range as alternative cutoffs. Regarding temporal trends of serum levels, SCC and CEA were similar. Their concentrations fell rapidly after surgery and thereafter remained relatively stable.ConclusionPostoperative serum SCC and CEA levels predict the overall survival of ESCC surgical patients. More importance should be attached to the use of these markers in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma

Huang,

Liu,

et al. 2023

Front. Oncol.

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“…Little is known about the biological regulation of STIP1 in head and neck cancers. High STIP1 expression was associated with shorter overall survival in patients with papillary thyroid carcinoma ( 24 ), and STIP1 serological autoantibodies were correlated with early-stage esophageal squamous cell carcinomas ( 25 , 26 ). Here, we found that STIP1 is overexpressed in OSCCs compared to non-tumor tissues, and its overexpression is an independent prognostic marker for poor outcomes, making it an attractive therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

et al. 2023

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ObjectiveAlthough there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little has been applied in the prognosis and choosing the optimal treatment. In this study, we explored the influence of the stress induced phosphoprotein 1 (STIP1), which is frequently reported to be highly expressed in many cancers, in OSCCs.MethodsSTIP1 expression was assessed in the TCGA database and in two independent cohorts by immunohistochemistry. Knockdown strategy was applied in OSCC cell lines to determine the impact of STIP1 on viability, proliferation, migration and invasion. The zebrafish model was applied for studying tumor formation and metastasis in vivo. The association of STIP1 and miR-218-5p was explored by bioinformatics and mimics transfection.ResultsSTIP1 was highly expressed in OSCCs and significantly associated with shortened survival and higher risk of recurrence. STIP1 down-regulation decreased proliferation, migration and invasion of tumor cells, and reduced the number of metastases in the Zebrafish model. STIP1 and miR-218-5p were inversely expressed, and the transfection of miR-218-5p mimics into OSCC cells decreased STIP1 levels as well as proliferation, migration and invasion.ConclusionOur findings show that STIP1 overexpression, which is inversely associated with miR-218-5p levels, contributes to OSCC aggressiveness by controlling proliferation, migration and invasion and is a determinant of poor prognosis.

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“…Furthermore, immunoglobulins against self-antigens and tumour-associated antigens (TAAs) have been found both in the serum of patients with cancer and in the tumour microenvironment [ 7 , 8 ]. Tumours can produce TAAs either by mutational mechanisms (mutated tumour-specific antigens, mTSAs) or by non-mutational mechanisms (non-mutational TAAs, nmTAAs), which could be overexpressed in cancer compared to normal tissue or may be cancer-specific.…”

Section: Introductionmentioning

confidence: 99%

“…TAAs may induce an immune response. Humoral immune surveillance mechanisms may be protective against tumour cells and inhibit cancer growth, however, if the antigens are not tumour specific, the immune system can also recognize antigen-expressing non-malignant cells resulting in autoimmune reactions [ 7 , 9 , 10 ]. However, the propensity of tumour cells to escape immune surveillance may be a key step in tumorigenesis [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antibodies as biomarkers for cancer risk: a systematic review

Crescioli

Beckmann

Lê

et al. 2022

Clinical and Experimental Immunology

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Summary Increasing evidence has linked the humoral immune response with the development of various cancers. Therefore, there is growing interest in investigating the predictive value of antibodies to assess overall and tissue site-specific cancer risk. Given the large amount of antibody types and the broad scope of the search (i.e., cancer risk), the primary aim of this systematic review was to present an overview of the most researched antibodies (i.e., immunoglobulin (Ig) isotypes (IgG, IgM, IgA, IgE), tumour and self antigen-reactive antibodies, infection-related antibodies) in relation to overall and site-specific cancer risk. We identified various antibody types that have been associated with the risk of cancer. While no significant associations were found for IgM serum levels, studies found an inconsistent association between IgE, IgA and IgG serum levels in relation to cancer risk. When evaluating antibodies against infectious agents, most studies reported a positive link with specific cancers known to be associated with the specific agent recognised by serum antibodies (i.e., helicobacter pylori and gastric cancer, hepatitis B virus and hepatocellular carcinoma, human papilloma virus and cervical cancer). Several reports identified autoantibodies, as single biomarkers (e.g., anti-p53, anti-MUC1, anti-CA125) but especially in panels of multiple autoantibodies, to have potential as diagnostic biomarkers for specific cancer types. Overall, there is emerging evidence associating certain antibodies to cancer risk, especially immunoglobulin isotypes, tumour-associated antigen-specific and self-reactive antibodies. Further experimental studies are necessary to assess the efficacy of specific antibodies as markers for early diagnosis of cancer.

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Tumor-associated autoantibodies in ESCC screening: Detecting prevalent early-stage malignancy or predicting future cancer risk?

Cited by 8 publications

References 43 publications

Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma

Postoperative serum squamous cell carcinoma antigen and carcinoembryonic antigen predict overall survival in surgical patients with esophageal squamous cell carcinoma

Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

Antibodies as biomarkers for cancer risk: a systematic review

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