Tumor Antigens

Phillips, Murray G.

doi:10.1159/000230281

Cited by 1 publication

(1 citation statement)

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“…A multipotent stem cell that can give rise to all hematopoietic lineages, has been demonstrated in this species, but a more restricted lymphoid progenitor, with its Ig genes in germline configuration, most probably contributes to the massive daily production of B cells by ongoing rearrangement. What the exact phenotype of such cells is, when and where they are formed and whether this is accomplished during a single early wave in a specific microenvironment, is not totally clear at present (reviewed in Phillips, 1989).…”

Section: Introductionmentioning

confidence: 99%

Emergence of committed B lymphoid progenitors in the developing chicken embryo.

et al. 1992

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The formation of B lymphoid restricted progenitors was followed during chicken embryonic development by monitoring the appearance of the various Ig gene rearrangements (DJH, VHDJH, VAJX), at a sensitivity that allows the detection of a single rearranged cell. By quantifying the DJH committed progenitor populations, we describe their evolution in different compartments at different developmental stages. The yolk sac is the first site where DJH-positive cells are observed (at days 5-6 of development); via the general circulation, they then seed the various organs while undergoing VHDJH and VXJX rearrangements, which occur simultaneously but lag behind DJH by one to several days. These progenitor populations decline with time in most lymphoid sites and only expand in the bursa. RAG-I expression is observed in the bursa in the absence of ongoing rearrangement activity and thus appears to be an improper marker of rearrangement in the chicken. Commitment to the B cell lineage seems to result from an intrinsic cell program, but the survival and expansion of the committed B progenitors require the specific microenvironment of the bursa.

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Section: Introductionmentioning

confidence: 99%