Tumid lupus erythematosus: Criteria for classification with immunohistochemical analysis

Abstract

Comprehensive clinical, histopathologic, and immunohistochemical criteria for the classification of tumid LE are proposed that differentiate tumid LE from other cutaneous disorders that may be clinically and histologically indistinguishable. The chronic, benign course indicates that tumid LE be classified as a form of chronic cutaneous LE, although it may be a cutaneous feature of systemic LE.

Lupus erythematosus tumidus in Japan: a case report and a review of the literature

“…These findings suggest that not only sun exposure but any other environmental factor might be involved in the provocation of LET lesions. Moreover, although direct immunofluorescence staining of skin specimens was positive in 50% of the Japanese cases, which was much higher than that reported in Kuhn's report [15], another group has reported similar results to ours [16].…”

Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: A manifestation of immune restoration

“…8,9 No doubt, the flux of CD4 T cells caused by HIV infection and intermittent HAART partly underlies the T-cell immunohistochemical findings that we have observed.…”

Role of Anti-Tumor Necrosis Factor-α Blockers in Inducing Lupus Erythematosus Tumidus in “Rhupus Syndrome”

“…Skin biopsy histopathology showed moderately dense superficial and deep perivascular and periappendageal lymphocytic infiltrate with dilatation of capillaries in the upper dermis and abundant deposits of mucin in the reticular dermis. The dermoepidermal junction and epidermis was relatively spared by the infiltrate and the epidermis was slightly flattened (Figure 2), and this was consistent with lupus erythematosus tumidus (LET) 4 . She showed no evidence of systemic involvement.…”