Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: A manifestation of immune restoration

Chamberlain, Alex J; Hollowood, Kevin; Turner, Richard; Byren, Ivor

doi:10.1016/j.jaad.2004.04.020

Cited by 24 publications

(7 citation statements)

References 34 publications

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“…Subacute lupus has been described as a side effect of isoniazid therapy in patients with tuberculosis [5]. In addition, a few cases of cutaneous lupus have been reported as a manifestation of the immune reconstitution syndrome [6, 7].…”

Section: Discussionmentioning

confidence: 99%

Lupus Masquerading as a Drug Reaction in HIV Infection

2019

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An HIV-positive female on antiretroviral therapy (ART) presented with an annular eruption diagnosed as a drug reaction based on histology of a lichenoid dermatitis. She responded to oral steroid therapy and discontinuation, but progressed to develop features in keeping with cutaneous lupus. Although the antinuclear factor remained negative, her low serum complement levels, histology, and clinical features pointed to a diagnosis of subacute lupus in the setting of HIV infection. She responded well to antimalarial therapy and recommenced ART.

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Section: Discussionmentioning

confidence: 99%

Lupus Masquerading as a Drug Reaction in HIV Infection

2019

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“…Patients with LET and positive ANA more frequently show signs of photosensitivity [4]. LET may be provoked by the use of certain medications such as antiviral agents [6], bortezomib [7], adalimumab [8], and ACE-inhibitors [9]. A case of LET has been described in a patient who had undergone a sex reassignment operation and was on hormone therapy [10].…”

Section: Discussionmentioning

confidence: 99%

Lupus Tumidus: underreported variant of lupus erythematosus (a case report and review of the literature)

Kazlouskaya¹,

Lal²,

Khaikova³

2014

Our Dermatol Online

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Introduction: Lupus erythematosus tumidus (LET) is an underreported variant of lupus erythematosus (LE) that is characterized by soft urticarial-like elements usually located on the sun exposed skin. LET is featured with high photosensitivity. Lesions of LET resolve without scarring and do not cause disfigurement as seen in the discoid LE variants. Lesions of LET may co-exist with other variants of LE: discoid or systemic.Main observations: The case presents a female patient with LET localized on the lateral infraorbital areas of her face and cheeks. Histopathological evaluation showed a lymphocytic infiltrate in the middle and deeper parts of the dermis. This article also presents a contemporary review of the clinical variants of LET, histopathological features and approaches to the treatment of LET. Conclusions: LET should be considered in urticarial-like lesions on the skin of the face and other skin exposed areas. Histopathological examination is needed to make a definitive diagnosis of the condition and helps in cases when the clinical presentation is subtle or nonspecific.

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“…Other cases of immune restoration‐related inflammatory disorders include appendicitis, 12 eosinophilic folliculitis, 13 sarcoidosis, 14 granulomatous reactions to tattoos, 15 and inflammation of warts and mollusca 6 . There are isolated reports of autoimmune thyroid diseases, 16 alopecia areata universalis, 17 subacute cutaneous lupus erythematosus, 18 tumid lupus erythematosus 19 and systemic lupus erythematosus 20 . In IRIS, an immune response to presumed previously nondetected antigens or subclinical or residual infections – at the time when CD4+ T cells are increasing rapidly – has been postulated.…”

Section: Discussionmentioning

confidence: 99%

Progressive supravenous granulomatous nodular eruption in a human immunodeficiency virus-positive intravenous drug user treated with highly active antiretroviral therapy

et al. 2007

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We describe a 41-year-old human immunodeficiency virus-infected woman with a previous history of intravenous drug abuse, who developed multiple linear nodules following the superficial veins on both arms. Histopathological examination disclosed a dermal histiocytic inflammatory reaction with sarcoid-like granuloma formation occasionally showing an intracytoplasmic refractile material in the histiocytic cells. Nodular lesions developed progressively after starting on highly active antiretroviral therapy (HAART) which increased her CD4 cell count and suppressed her viral load. The appearance of latent inflammatory or autoimmune disease following HAART is a well-recognized phenomenon. We consider that this peculiar 'progressive supravenous granulomatous nodular eruption' should be included within the spectrum of the so-called immune reconstitution inflammatory syndrome.

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Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: A manifestation of immune restoration

Cited by 24 publications

References 34 publications

Lupus Masquerading as a Drug Reaction in HIV Infection

Lupus Masquerading as a Drug Reaction in HIV Infection

Lupus Tumidus: underreported variant of lupus erythematosus (a case report and review of the literature)

Progressive supravenous granulomatous nodular eruption in a human immunodeficiency virus-positive intravenous drug user treated with highly active antiretroviral therapy

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