Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma

Abstract

Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.

Fine‐needle aspiration of tubulocystic renal cell carcinoma

“…Since the tumor is composed of cells with abundant granular cytoplasm, the differential includes clear cell/conventional RCC, papillary RCC, chromophobe RCC, oncocytoma, hereditary leiomyomatosis associated RCC, and succinate‐dehydrogenase B deficiency associated RCC (Table ). The differential also includes several lesions other than RCC, including normal proximal tubular cells, granular cell tumor, angiomyolipoma, and xanthogranulomatous pyelonephritis.…”

“…Tubulocystic renal cell carcinoma (RCC) is a rare (<100 cases reported in the literature), recently described variant of RCC with a relatively indolent prognosis, though bone metastases have been reported . This tumor is composed a variably sized tubules and cysts lined by a single layer of cells with relatively abundant granular, eosinophilic cytoplasm, and large round nuclei with relatively prominent nucleoli embedded in an evenly fibrotic stroma.…”

Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach

“…Tubulocystic RCC (TC-RCC) is a relative new entity first officially included in the 2012 ISUP Vancouver Classification. Similar to MTSCC, TC-RCC has morphologic and immunohistochemical features that are frequently overlap with PRCC [36,96,97].…”

“…The genetic features of these tumors are variable with previous studies suggesting similar CNV patterns to that reported in type 1 PRCC (gain of chromosome 7 or 17 and loss of Y). However, more recent studies showed that gain of chromosomes 7 and 17 is not a typical CNV pattern in cases of TC-RCC where strict histo-diagnostic criteria are applied [96][97][98]. In fact, loss of chromosome 9 has been suggested as a characteristic feature of TC-RCC [99].…”

A contemporary series of renal masses with emphasis on recently recognized entities and tumors of low malignant potential: A report based on 624 consecutive tumors from a single tertiary center

“…However, some categories still labeled as "carcinoma", including clear cell papillary renal cell carcinoma (CCPRCC), renal angioleiomyomatous tumor (RAT), and tubulocystic carcinoma (TCRCC), all with a particularly good prognosis when diagnosed as low stage (pT1a), show no malignant behavior: in fact, no metastases have been reported in these categories when surgically excised [5][6][7][8][9][10][11][12][13][14]. RAT is also considered by most authors as a morphologic variation of CCPRCC [15][16][17].…”