A contemporary series of renal masses with emphasis on recently recognized entities and tumors of low malignant potential: A report based on 624 consecutive tumors from a single tertiary center

Raspollini, Maria Rosaria; Montagnani, Ilaria; Montironi, Rodolfo; Cheng, Liang; Martignoni, Guido; Minervini, Andrea; Serni, Sergio; Nicita, Giulio; Carini, Marco; López-Beltrán, Antonio

doi:10.1016/j.prp.2017.03.007

Cited by 11 publications

(1 citation statement)

References 32 publications

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“…According to the World Health Organization (2016) tumor pathology and genetic classi cation standards for urinary system and male reproductive system, renal cell carcinoma is now divided into 10 types according to different pathological types in the world [9] , among which multilocular cystic renal cell carcinoma is very rare, accounting for only 1-2% of renal malignancies, and MCRNLMP is even rarer, accounting for less than 1% of all renal malignancies [13] . Generally speaking, the tumor grade is low, and the number of malignant tumor cells within it is also very small, so the prognosis is relatively good, and there is no obvious correlation between the size of the tumor diameter and the prognosis [7] .…”

Section: Discussionmentioning

confidence: 99%

Computed tomography (CT) scanned renal cyst and pathological multilocular cystic renal neoplasm of low malignant potential (MCRNLMP): a patients’ management report of 1520 cases

Gao

Zhang

et al. 2023

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Background The association between computed tomography (CT) imaging characteristics and clinical growth rate of multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) have not been reported. Our study focused on the correlation of CT imaging and growth rate to investigate the distinguished characteristics in MCRNLMP versus renal cysts, and explore the optimized management.Methods Data regarding 1520 patients including 1,444 patients with renal cysts and 76 patients with MCRNLMP who underwent renal cyst decompression, radical nephrectomy, or nephron sparing surgery due to renal cystic disease between Jan 2013 and Dec 2021 in our institution were retrospectively collected and analyzed. Bosniak classification for imaging modality and the 2016 WHO criteria for clinic pathology were used for detection of MCRNLMP.Results In our study, MCRNLMP accounted for 1.48% of patients with “simple renal cysts”, 5.26% of the patients with “complex renal cysts”, and 12.11% of the patients with “renal tumors combined with renal cysts” (P < 0.001); MCRNLMP accounted for 22.37% and 0.66% of patients with cysts’ growth rate ≥ 2.0 cm/year and < 2.0 cm/year, repectively. Of 76 MCRNLMP cases, after renal cyst de-topping decompression, no recurrence or metastasis was found in 9 patients who underwent nephron-sparing surgery or radical nephrectomy again, while only 1 suspicious recurrence was found by CT of 67 patients underwent actively monitored in postoperative 3-year follow-up.Conclusions MCRNLMP and renal cysts can be slightly identified through the potential predictors of Computed tomography (CT) scanning and growth rate. For MCRNLMP, partial nephrectomy is the first choice and radical nephrectomy should be avoided as much as possible, in addition, active monitoring can also be adopted after surgery to avoid unnecessary nephrectomy.

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Section: Discussionmentioning

confidence: 99%

Computed tomography (CT) scanned renal cyst and pathological multilocular cystic renal neoplasm of low malignant potential (MCRNLMP): a patients’ management report of 1520 cases

Gao

Zhang

et al. 2023

Preprint

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Staging and Reporting of Renal Cell Carcinomas

et al. 2019

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Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum

et al. 2018

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Multilocular cystic renal cell carcinoma has been recently excluded from clear cell renal cell carcinoma (CCRCC) category and re-designated as multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) due to its uniformly good outcomes. While strict distinction between MCRNLMP from predominantly cystic CCRCC (pc-CCRCC) is being emphasized, the significance of extensive true cystic component in CCRCC has not been investigated. Herein, we analyzed 57 MCRNLMP, 69 pc-CCRCC, and 46 non-cystic CCRCC. There were no statistically significant differences between the three subtypes in age, gender, and laterality. ISUP grades were 1 (73%) or 2 (27%) for MCRNLMP; for pc-CCRCC were 1 (31%), 2 (60%), and 3 (9%); and for non-cystic CCRCC were 1 (9%), 2 (52%), 3 (26%), and 4 (13%). MCRNLMP were either pT stage 1 (91%) or 2 (9%), pT stages for pc-CCRCC were 1 (92.5%), 2 (1.5%), and 3 (6%) and for non-cystic CCRCC were 1 (58.7%), 2 (6.5%), and 3 (34.8%). None of MCRNLMP patients developed recurrences or metastases, and only 1 contralateral kidney tumor and 1 metastasis developed in pc-CCRCC. In contrast, 19 patients with non-cystic CCRCC developed metastases (5-year PFS 58%, CI 38.3-73.5%), and 1 patient died of disease. Monosomy 3 was common in both MCRNLMP (3/3) and pc-CCRCC (6/7). This large series of MCRNLMP confirms its indolent behavior, shows that pc-CCRCC has significantly better prognosis than non-cystic CCRCC and may define the lower grade spectrum of CCRCC. We recommend that the presence and extent of CCRCC cystic component should be documented in the pathology report.

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A contemporary series of renal masses with emphasis on recently recognized entities and tumors of low malignant potential: A report based on 624 consecutive tumors from a single tertiary center

Abstract: This information may assist urologists in developing guidelines for counseling and proper clinical management for patients with "low malignant potential" tumors or small renal masses.

Cited by 11 publications

References 32 publications

Computed tomography (CT) scanned renal cyst and pathological multilocular cystic renal neoplasm of low malignant potential (MCRNLMP): a patients’ management report of 1520 cases

Computed tomography (CT) scanned renal cyst and pathological multilocular cystic renal neoplasm of low malignant potential (MCRNLMP): a patients’ management report of 1520 cases

Staging and Reporting of Renal Cell Carcinomas

Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum

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