Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor

Bhullar, Jasneet Singh; Bindroo, Sandiya; Varshney, Neha; Mittal, Vijay K.

doi:10.15586/jkcvhl.2014.13

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Histologically, it shows enlarged nucleoli and an eosinophilic cytoplasm similar to oncocytomas [5]. Therefore, the differentiation of tcRCC from other RCC subtypes and oncocytomas may be difficult [106]. However, molecular profiling, as well as a unique miRNA expression profile may facilitate diagnosis of tcRCC.…”

Section: Discussionmentioning

confidence: 99%

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

Barth

Slabý

Klec

et al. 2019

Cancers

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Renal cell carcinoma (RCC) is a relatively rare malignancy of the urinary tract system. RCC is a heterogenous disease in terms of underlying histology and its associated underlying pathobiology, prognosis and treatment schedule. The most prevalent histological RCC subtype is clear-cell renal cell carcinoma (ccRCC), accounting for about 70–80% of all RCCs. Though the pathobiology and treatment schedule for ccRCC are well-established, non-ccRCC subtypes account for 20%–30% of RCC altogether, and their underlying molecular biology and treatment options are poorly defined. The class of non-coding RNAs—molecules that are generally not translated into proteins—are new cancer drivers and suppressors in all types of cancer. Of these, small non-coding microRNAs (miRNAs) contribute to carcinogenesis by regulating posttranscriptional gene silencing. Additionally, a growing body of evidence supports the role of long non-coding RNAs (lncRNAs) in cancer development and progression. Most studies on non-coding RNAs in RCC focus on clear-cell histology, and there is a relatively limited number of studies on non-ccRCC subtypes. The aim of this review is to give an overview of the current knowledge regarding the role of non-coding RNAs (including short and long non-coding RNAs) in non-ccRCC and to highlight possible implications as diagnostic, prognostic and predictive biomarkers.

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Section: Discussionmentioning

confidence: 99%

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

Barth

Slabý

Klec

et al. 2019

Cancers

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“…2 ). 4 The presence of focal metaplastic bone formation and oncocytic features were noted ( Fig. 3 ).…”

Section: Introductionmentioning

confidence: 96%

A unique presentation of a rare renal cancer: Appearance of bone metaplasia in tubulocystic renal cell carcinoma

O'Connor

Phillis

Pardo

et al. 2021

Urology Case Reports

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Tubulocystic renal cell carcinoma is a rare cancer that was not defined as a distinct entity until the early 2000s. Due to the recency of its classification, it remains poorly understood and leaves much room for future research. This report looks at a unique case of this rare subtype of renal cancer. This specific case is unique due to both the demographics of the affected patient and the finding of bone metaplasia within the tumor. We believe this is the first ever reported incidence of this phenomenon.

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“…It shares several similarities with other renal tumors but has a distinct macroscopic, microscopic, and immunohistochemical feature. Furthermore, it has been recognized as a distinct entity in the 2012 Vancouver classification of renal tumors [ 1 ]. It can occur both in native and transplant kidneys.…”

Section: Introductionmentioning

confidence: 99%

Rarest of the Rare Metastatic Tubulocystic Carcinoma of Kidney

Yousuf

Kumar

Al-Moundhri

2020

Cureus

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Tubulocystic carcinoma of the kidney is a rare neoplasm with <100 case reports. Patients are usually asymptomatic and have a relatively indolent disease course occurring predominantly in males. These tumors rarely metastasize. It was previously considered to have some similarities to various other renal cancers, although this tumor has distinct macroscopic, microscopic, and immunohistochemical features. It is now a well-established entity in renal neoplastic pathology. Herein we present a case of metastatic tubulocystic carcinoma presenting with bony metastasis.

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Tubulocystic Renal Cell Carcinoma: A Rare Renal Tumor

Cited by 7 publications

References 20 publications

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma

A unique presentation of a rare renal cancer: Appearance of bone metaplasia in tubulocystic renal cell carcinoma

Rarest of the Rare Metastatic Tubulocystic Carcinoma of Kidney

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